A Crucial Role for the Homeodomain Transcription Factor Hhex in Lymphopoiesis Investigators found that loss of Hhex was tolerated in hematopoietic stem cells and myeloid lineages, but resulted in a progressive loss of B-lymphocytes in the circulation. [Blood] Abstract The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis Scientists demonstrate that nucleosome remodeling and deacetylase and positive-transcription elongation factor b are assembled in a complex that can be recruited to specific genes by IKAROS. They show that an IKAROS mutant that is unable to bind protein phosphatase 1α cannot sustain gene expression and impedes normal differentiation of IkNULL hematopoietic progenitors. [PLoS Genet] Full Article CD41 Marks the Initial Myelo-Erythroid Lineage Specification in Adult Mouse Hematopoiesis: Redefinition of Murine Common Myeloid Progenitor Researchers show that the counterpart of GATA-1-activating myelo-erythroid progenitor resides also at the Lineage– Sca-1+ c-Kit+ stage, expressing CD41 at a high level. [Stem Cells] Abstract Anti-CD33 Chimeric Antigen Receptor Targeting of Acute Myeloid Leukemia Scientists generated a second generation CD33-specific chimeric antigen receptor capable of redirecting cytolytic effector T cells against leukemic cells. Chimeric antigen receptor-modified T cells efficiently killed leukemia cell lines and primary tumor cells in vitro. [Haematologica] Abstract | Full Article A Multicolor Panel of TALE-KRAB Based Transcriptional Repressor Vectors Enabling Knockdown of Multiple Gene Targets Scientists show that the transcription activator-like effector (TALE)-Krüppel-associated box (KRAB) vector system when combined together with bone marrow transplantation could quickly knock down c-kit and PU.1 genes in hematopoietic stem and progenitor cells of recipient mice. [Sci Rep] Full Article The Epigenetic Regulator CXXC Finger Protein 1 Is Essential for Murine Hematopoiesis Mice homozygous for a conditional Cxxc1 deletion allele and carrying the inducible Mx1-Cre transgene were generated to assess CXXC finger protein 1 function in adult animals. [PLoS One] Full Article Ultra-Endurance Exercise Induces Stress and Inflammation and Affects Circulating Hematopoietic Progenitor Cell Function Scientists aimed to determine the impact of ultra-endurance exercise-induced stress on the number and function of circulating hematopoietic progenitor cells and hematological, inflammatory, clinical, metabolic, and stress parameters in moderately trained amateur athletes. [Scand J Med Sci Sports] Abstract CLINICAL RESEARCH A Survey on Unmanipulated Haploidentical Hematopoietic Stem Cell Transplantation in Adults with Acute Leukemia Investigators analyzed the outcome of 229 adult patients with de novo acute leukemia, who received an unmanipulated haploidentical transplant as their first allogeneic hematopoietic stem cell transplantation. [Leukemia] Abstract Superior Outcome Using Cyclosporin A Alone versus Cyclosporin A plus Methotrexate for Post-Transplant Immunosuppression in Children with Acute Leukemia Undergoing Sibling Hematopoietic Stem Cell Transplantation The outcome of cyclosporin A (CSA) alone as graft-versus-host disease prophylaxis was compared to that of CSA combined with methotrexate in children with acute leukemia who underwent hematopoietic stem cell transplantation. [J Cancer Res Clin Oncol] Abstract Multicenter Analysis of Treatment Outcomes in Adult Patients with Lymphoblastic Lymphoma Who Received Hyper-CVAD Induction followed by Hematopoietic Stem Cell Transplantation Investigators evaluated the efficacy of hyper-CVAD induction and stem cell transplantation consolidation in LBL patients. The treatment responses of 49 patients treated with the hyper-CVAD regimen were retrospectively analyzed in 13 institutions. [Ann Hematol] Abstract |