Inducible RNAi In Vivo Reveals that the Transcription Factor BATF Is Required to Initiate but Not Maintain CD8+ T-Cell Effector Differentiation Scientists demonstrate that lentivirus-transduced progenitor cells could reconstitute normal hematopoiesis and develop into naive CD8+ T cells that were indistinguishable from wild-type naive T cells. This experimental system enabled induction of efficient gene knockdown in vivo without subsequent manipulation. [Proc Natl Acad Sci USA] Abstract Inflammatory Signaling Regulates Hematopoietic Stem and Progenitor Cell Emergence in Vertebrates Researchers demonstrate that in both zebrafish and mouse embryos, inflammatory signaling is necessary and sufficient for hematopoietic stem and progenitor cell emergence, in the absence of infection or pathological inflammation. [Blood] Abstract The RUNX1 +24 Enhancer and P1 Promoter Identify a Unique Subpopulation of Hematopoietic Progenitor Cells Derived from Human Pluripotent Stem Cells Investigators used a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells derived from human embryonic stem cells and human induced pluripotent cells. [Stem Cells] Abstract Hematopoietic Stem/Progenitor Cells Directly Contribute to Arteriosclerotic Progression via Integrin Β2 Researchers hypothesized that circulating hematopoietic stem/progenitor cells may home to inflamed vessels, where they might contribute to inflammation and neointima formation. [Stem Cells] Abstract | Full Article Contrasting Roles for C/EBPα and Notch in Irradiation-Induced Multipotent Hematopoietic Progenitor Cell Defects Investigators demonstrate that ionizing radiation causes long-term, somatically heritable, cell-intrinsic reductions in hematopoietic stem cell and multipotent hematopoietic progenitor cell self-renewal that are mediated by C/EBPα and reversed by Notch. [Stem Cells] Abstract | Press Release Role of the Clathrin Adaptor PICALM in Normal Hematopoiesis and Polycythemia Vera Pathophysiology Scientists show, by employing a series of conditional Picalm knockout mice, that PICALM critically regulates transferrin uptake in erythroid cells by functioning as a cell-type-specific regulator of transferrin receptor endocytosis. [Haematologica] Abstract | Full Article The Possible Role of Liver Kinase B1 in Hydroquinone-Induced Toxicity of Murine Fetal Liver and Bone Marrow Hematopoietic Stem Cells Researchers hypothesize that liver kinase B1 contributes to the deregulation of fetal or bone hematopoiesis caused by the benzene metabolite hydroquinone. [Environ Toxicol] Abstract CLINICAL RESEARCH Ibrutinib for Previously Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia with TP53 aberrations: A Phase II, Single-Arm Trial Investigators enrolled eligible adult patients with active chronic lymphocytic leukemia with TP53 aberrations at the National Institutes of Health Clinical Center. Patients received 28-day cycles of ibrutinib 420 mg orally once daily until disease progression or the occurrence of limiting toxicities. [Lancet Oncol] Abstract | Press Release Single and Multiple Dose MultiStem® (Multi-Potent Adult Progenitor Cell) Therapy Prophylaxis of Acute GvHD in Myeloablative Allogeneic Hematopoietic Cell Transplantation: A Phase I Trial Researchers conducted a multi-center, Phase I dose escalation study evaluating safety of the allogeneic multipotent adult progenitor cell stromal product administered as an adjunct therapy to 36 patients after myeloablative allogeneic hematopoietic cell transplantation. [Biol Blood Marrow Transplant] Abstract Prevalence and Clinical Significance of Potential Drug-Drug Interaction in Hematopoietic Stem Cell Transplantation Investigators performed a cross-sectional study based on the evaluation of prescriptions to hematopoietic stem cell transplantation patients on the day of infusion. The potential drug-drug interactions were analyzed using the DRUG-REAX® system and classified according to the severity level, available scientific evidence, time of onset, and potential clinical impact. [Cancer Chemother Pharmacol] Abstract Hematopoietic Stem Cell Transplantation following Unsuccessful Salvage Treatment for Relapsed Acute Lymphoblastic Leukemia in Children The medical records of 55 children with acute lymphoblastic leukemia who underwent stem cell transplantation following the experience of re-induction failure or multiple relapses were retrospectively analyzed. [Pediatr Blood Cancer] Abstract |