MOZ Regulates B Cell Progenitors and, Consequently, Moz Haploinsufficiency Dramatically Retards MYC-Induced Lymphoma Development The histone acetyltransferase MOZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p300, NCOA3 or TIF2 in particularly aggressive cases of acute myeloid leukemia. Scientists report the role of wild-type MOZ in regulating B cell progenitor proliferation and hematopoietic malignancy. [Blood] Abstract Epigenomic Analysis of the HOX Gene Loci Reveals Mechanisms that May Control Canonical Expression Patterns in AML and Normal Hematopoietic Cells Investigators analyzed RNA sequencing data from 179 primary acute myeloid leukemia (AML) samples and normal hematopoietic cells to understand the range of expression patterns in normal versus leukemic cells. HOX expression in AML was restricted to specific genes in the HOXA or HOXB loci, and was highly correlated with recurrent cytogenetic abnormalities. [Leukemia] Abstract Interplay of H2A Deubiquitinase 2A-DUB/Mysm1 and the p19ARF/p53 Axis in Hematopoiesis, Early T-Cell Development and Tissue Differentiation To explore the interplay of histone H2A deubiquitinase Myb-like SWIRM and MPN domain containing1 (2A-DUB/Mysm1) with the p53 axis in the sequential differentiation of mature lymphocytes from progenitors, scientists systematically analyzed hematopoiesis and early T-cell development using Mysm1-/- and p53-/-Mysm1-/- mice. [Cell Death Differ] Full Article Hematopoietic Stem/Progenitor Cells Express Several Functional Sex Hormone Receptors-Novel Evidence for a Potential Developmental Link between Hematopoiesis and Primordial Germ Cells Researchers tested the expression of receptors for pituitary-derived hormones, such as follicle-stimulating hormone and luteinizing hormone, on purified murine bone marrow cells enriched for hematopoietic stem progenitor cells and tested the functionality of these receptors in ex vivo signal transduction studies and in vitro clonogenic assays. [Stem Cells Dev] Abstract Catalase Inhibits Ionizing Radiation-Induced Apoptosis in Hematopoietic Stem and Progenitor Cells Investigators evaluated the efficacy of catalase as a protectant against ionizing radiation (IR)-induced toxicity in hematopoietic stem and progenitor cells. The results revealed that catalase treatment markedly inhibits IR-induced apoptosis in murine hematopoietic stem cells and hematopoietic progenitor cells. [Stem Cells Dev] Abstract Autophagy Collaborates with Ubiquitination to Downregulate Oncoprotein E2A/Pbx1 in B-Cell Acute Lymphoblastic Leukemia With a pediatric t(1;19) B-cell acute lymphoblastic leukemia xenograft mouse model, scientists show that activation of autophagy by preventive administration of rapamycin improved the survival of leukemia animals by partial restoration of hematopoietic stem/progenitor cells, whereas treatment of the animals with rapamycin caused leukemia bone marrow cell-cycle arrest. [Blood Cancer J] Full Article CLINICAL RESEARCH Association of Nonmyeloablative Hematopoietic Stem Cell Transplantation with Neurological Disability in Patients with Relapsing-Remitting Multiple Sclerosis Investigators aimed to determine the association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability and other clinical outcomes in patients with multiple sclerosis. [JAMA] Abstract | Press Release | Editorial Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients with Mixed Phenotype Acute Leukemia: Results of a Matched-Pair Analysis Researchers retrospectively assessed the efficacy of allogeneic stem cell transplantation for mixed phenotype acute leukemia (MPAL). Eighteen patients with MPAL were identified from the transplant outcome database of KSGCT. [Eur J Haematol] Abstract |