Hematopoiesis News Volume 6.05 | Feb 10 2015

Mutated Ptpn11 Alters Leukemic Stem Cell Frequency and Reduces the Sensitivity of Acute Myeloid Leukemia Cells to Mcl1 Inhibition
The authors report that Shp2 mutations occur in human acute myeloid leukemia (AML) at a rate of 6.6% in the ECOG E1900 dataset. They examined the role of mutated Shp2 in leukemias harboring myelomonocytic leukemia translocations which co-occur in human AML. [Leukemia] Abstract

NF-κB-Dependent DNA Damage-Signaling Differentially Regulates DNA Double-Strand Break Repair Mechanisms in Immature and Mature Human Hematopoietic Cells
Investigators explored the activity, quality, and molecular components of DNA double-strand-break repair in human hematopoietic stem and progenitor cell as compared with mature peripheral blood lymphocytes. [Leukemia] Abstract

Lentivirus Mediated Gene Transfer in Hematopoietic Stem Cells Is Impaired in SHIV-Infected, ART-Treated Nonhuman Primates
Scientists show that SHIV⁺, antiretroviral therapy (ART)-treated animals had very low gene marking levels after hematopoietic stem cell transplantation. [Mol Ther] Abstract

IGF-IR Determines the Fates of BCR/ABL Leukemia
Researchers investigated the role of insulin-like growth factor 1 receptor (IGF-IR) in chronic myeloid leukemia using the retroviral BCR/ABL transplantation mouse model. [J Hematol Oncol] Abstract | Full Article

Loss of Angiopoietin-Like 7 Diminishes the Regeneration Capacity of Hematopoietic Stem and Progenitor Cells
Investigators generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that hematopoietic stem cell compartments in Angptl7-null mice were compromised. [J Hematol Oncol] Abstract | Full Article

Chronic Myeloid Leukemia-Derived Exosomes Promote Tumor Growth through an Autocrine Mechanism
In a chronic myeloid leukemia xenograft model, treatment of mice with exosomes caused a greater increase in tumor size compared with controls. [Cell Commun Signal] Abstract | Full Article

CLINICAL RESEARCH

Allogeneic Hematopoietic Stem Cell Transplantation in Solid Organ Transplant Recipients: A Retrospective, Multicenter Study of the EBMT
Researchers conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation in recipients of solid organ transplantation. [Am J Transplant] Abstract

Extended Follow-Up of High-Dose Melphalan and Autologous SCT after Vincristine, Doxorubicin, Dexamethasone Induction in AL Amyloidosis of the Prospective Phase II HOVON-41 Study by the Dutch-Belgian Cooperative Trial Group for Hematology Oncology
Investigators evaluated the effect of three courses of vincristine, doxorubicin and dexamethasone followed by high-dose melphalan and autologous stem cell transplantation on an intention to treat basis. [Haematologica] Abstract | Full Article

Use of Eculizumab in Patients with Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy: A Study from the SFGM-TC
Thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation (HSCT) shares similarities with atypical hemolytic uremic syndrome (aHUS) in the underlying pathomechanisms. Eculizumab has been associated with impressive results in aHUS. Researchers retrospectively analyzed 12 patients who received eculizumab in France for severe post-HSCT thrombotic microangiopathy. [Transplantation] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Sangamo BioSciences Announces FDA Acceptance of IND to Initiate Clinical Trial of its Novel ZFP Therapeutic^® for Beta-Thalassemia
Sangamo BioSciences, Inc. announced that an Investigational New Drug (IND) application for the company’s SB-BCLmR-HSPC genome editing approach, which is designed to provide a one-time lasting therapy for beta-thalassemia, has been accepted by the U.S. Food and Drug Administration (FDA) and is now active. [Sangamo BioSciences, Inc.] Press Release

Three USC Researchers Win $4.3 Million in Awards from California’s Stem Cell Agency
Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. [University of Southern California] Press Release

Cord Blood Registry Announces Formation of Scientific & Medical Advisory Board
Cord Blood Registry^® (CBR^®) announced the establishment of a Scientific and Medical Advisory Board (SMAB). Composed of internationally renowned stem cell experts, the SMAB will provide input and guidance to help advance CBR’s mission to expand the scope of newborn stem cell therapies that may be available to patients and their families. [Cord Blood Registry^®] Press Release

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Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the hematopoiesis community.

NEW Director – Vector Production (Sangamo BioSciences, Inc.)

Research Technologist – Hematopoietic Product Development (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Hematopoietic Stem Cell Physiology and Pathophysiology (Kumamoto University)

Postdoctoral Fellow – Targeted Gene Editing in Hematopoietic Stem Cells (University Medical Center Freiburg)

Postdoctoral Position – Genetic Engineering and Transplantation of Hematopoietic Stem Cells (University of California – San Francisco)

Research Associate – Hematopoietic Stem Cells and Leukemia (City of Hope)

Postdoctoral Fellow – Hematopoiesis and Stem Cell Biology (Lund University)

Postdoctoral Research Scientist – Human T Cell Leukemia (Washington University School of Medicine)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

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