CD133 Marks a Stem Cell Population that Drives Human Primary Myelofibrosis Primary myelofibrosis is a myeloproliferative neoplasm characterized by bone marrow fibrosis, megakaryocyte atypia, extramedullary hematopoiesis, and transformation to acute myeloid leukemia. Researchers report a CD133+ stem cell population that drives primary myelofibrosis pathogenesis. [Haematologica] Abstract | Full Article Cocaine Exposure Impairs Multilineage Hematopoiesis of Human Hematopoietic Progenitor Cells Mediated by the Sigma-1 Receptor The authors present a novel and concise investigation into the mechanism that underlies cocaine associated hematopoietic pathology. They show that cocaine impairs multilineage hematopoiesis from human progenitors from multiple donors and tissue types. [Sci Rep] Full Article Characterization of Putative Hematopoietic Cells from Bovine Yolk Sac Investigators identified and characterized the putative hematopoietic cells from the yolk sac of bovine embryos at different stages of gestation. The yolk sac regresses according to gestational age and embryos are characterized into groups (I-V) according to the crown-rump measurement. [J Tissue Eng Regen Med] Abstract Cryopreservation of Cord Blood CD34+ Cells before or after Thrombopoietin Expansion Differentially Affects Early Platelet Recovery in NOD SCID Mice Researchers evaluated whether the order of cryopreservation and thrombopoietin expansion affected the expansion rate and numbers of clonogenic hematopoietic progenitor cells in vitro or platelet and longer-term hematopoietic repopulation in NOD SCID mice in vivo. [Transfusion] Abstract DNMT3A R882 Mutation Is Associated with Elevated Expression of MAFB and M4/M5 Immunophenotype of Acute Myeloid Leukemia Blasts Scientists investigated the connection between the typical immunophenotype of leukemic blasts and mutation of DNMT3A Arg882 (R882). They discovered the relation between DNMT3A R882 mutation and the expression of monocytic differentiation genes and its clinical significance. [Leuk Lymphoma] Abstract CLINICAL RESEARCH Randomized Phase II Study of GMI-1070 in SCD: Reduction in Time to Resolution of Vaso-Occlusive Events and Decreased Opioid Use Researchers studied GMI-1070 in a prospective multicenter, randomized, placebo-controlled, double-blind, Phase II study of 76 sickle cell disease patients with vaso-occlusive events. [Blood] Abstract | Press Release Plerixafor on Demand in Ten Healthy Family Donors as a Rescue Strategy to Achieve an Adequate Graft for Stem Cell Transplantation Researchers report ten healthy hematopoietic stem cell donors treated with plerixafor because of insufficient response to granulocyte-colony-stimulating (G-CSF) alone or contraindication to G-CSF. [Transfusion] Abstract Long-Term Outcomes of Autologous Hematopoietic Stem Cell Transplantation with Reduced-Intensity Conditioning in Multiple Sclerosis: Physician’s and Patient’s Perspectives Investigators present the long-term outcomes of a prospective single-center study with the analysis of the safety and efficacy of high-dose immunosuppressive therapy + autologous hematopoietic stem cell transplantation with reduced-intensity BEAM-like conditioning regimen in 99 multiple sclerosis patients. [Ann Hematol] Abstract One Million Hemopoietic Stem-Cell Transplants: A Retrospective Observational Study The authors aimed to document the activity worldwide from the beginning of transplantation and search for region adapted indications and associations between transplant rates and macroeconomics. [Lancet Haematol] Abstract | Press Release |