Ash1l Controls Quiescence and Self-Renewal Potential in Hematopoietic Stem Cells Researchers report an essential role for the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition. Emergence and expansion of Ash1l-deficient fetal/neonatal hematopoietic stem cells (HSCs) were preserved; however, in young adult animals, HSCs were profoundly depleted. [J Clin Invest] Full Article | Press Release The Aryl Hydrocarbon Receptor Nuclear Translocator Is an Essential Regulator of Murine Hematopoietic Stem Cell Viability Scientists conditionally deleted the hypoxia inducible factor α (HIF-α) dimerization partner, the aryl hydrocarbon receptor nuclear translocator (ARNT) in the hematopoietic system to ablate activity of both HIF-1α and HIF-2α and assessed the functional consequence of ARNT deficiency on fetal liver and adult hematopoiesis. [Blood] Abstract SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells Under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias Investigators demonstrated that Socs2 deficiency unleashes hematopoietic stem cell proliferation in vitro sustaining STAT5 phosphorylation in response to IL-3, thrombopoietin and GM-CSF. [Cancer Res] Abstract MYB Controls Erythroid versus Megakaryocyte Lineage Fate Decision through the miR-486-3p-Mediated Downregulation of MAF To further unravel the molecular mechanisms through which v-myb avian myeloblastosis viral oncogene homolog (MYB) affects lineage fate decision, scientists performed the integrative analysis of miRNA and mRNA changes in MYB-silenced human primary CD34+ hematopoietic progenitor cells. [Cell Death Differ] Full Article Targeting the Spliceosome in Chronic Lymphocytic Leukemia with the Macrolides FD-895 and Pladienolide B The authors report studies using FD-895 and pladienolide-B in primary leukemia cells derived from chronic lymphocytic leukemia patients and leukemia-lymphoma cell lines. They found that FD-895 and pladienolide-B induce an early pattern of mRNA intron retention – spliceosome inhibition. [Haematologica] Abstract | Full Article Potential Role of Notch Signaling in CD34+ Chronic Myeloid Leukemia Cells: Cross-Talk between Notch and BCR-ABL Researchers studied the relationship between BCR-ABL and Notch signaling and assessed the expression patterns of Notch and its downstream target Hes1 in CD34+ stem and progenitor cells from chronic-phase chronic myeloid leukemia patients and bone marrow from normal subjects. [PLoS One] Full Article CLINICAL RESEARCH Faster T-Cell Development following Gene Therapy Compared to Haplo-Identical Hematopoietic Stem Cell Transplantation in the Treatment of SCID-X1 Researchers retrospectively analyzed and compared clinical outcomes and immune reconstitution in 13 consecutive severe combined immunodeficiency caused by ILR2G mutation (SCID-X1) patients having undergone haploidentical hematopoietic stem cell transplantation and 14 SCID-X1 patients treated with gene therapy over the same period at a single center level. [Blood] Abstract | Full Article | Press Release Mobilization of Hematopoietic Progenitor Stem Cells in Allogeneic Setting with Lenograstim by Subcutaneous Injection, in Daily or Twice-Daily Dosing: A Single-Center Prospective Study with Historical Control Although the mobilization of hematopoietic progenitor stem cells from healthy donors (HDs) using granulocyte-colony-stimulating factor is widely used, the ideal method for the administration of the cytokine has not yet been determined. Seventy-five consecutive HDs received lenograstim as mobilization agent. [Transfusion] Abstract Outcomes of Mismatched and Unrelated Donor Hematopoietic Stem Cell Transplantation in Fanconi Anemia Conditioned with Chemotherapy Only Researchers present their experience with 17 Fanconi anemia patients who completed mismatched related or unrelated donor hematopoietic stem cell transplantation using a non-radiation fludarabine-based preparative regimen. [Ann Hematol] Abstract |