Hhex Is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation Conventional Hhex knockouts cause embryonic lethality precluding analysis of adult hematopoiesis. Thus, scientists induced highly efficient conditional knockout (cKO) using vav-Cre transgenic mice. Hhex cKO mice were viable and born at normal litter sizes. [Stem Cells] Abstract ROS-Mediated Iron Overload Injures the Hematopoiesis of Bone Marrow by Damaging Hematopoietic Stem/Progenitor Cells in Mice The authors investigated the effects of iron overload on the hematopoietic stem and progenitor cells (HSPCs) from a mouse model. Their results showed that iron overload markedly decreased the ratio and clonogenic function of murine HSPCs by the elevation of reactive oxygen species (ROS). [Sci Rep] Full Article Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukemia Investigators delineated the mechanisms underlying stroma-mediated chemoresistance in acute myeloid leukemia (AML). They used two human bone marrow stromal cell lines, HS-5 and HS-27A, which are equally effective in protecting AML cells from chemotherapy-induced apoptosis in AML-stromal co-cultures. [Br J Haematol] Abstract Impact of the Immunomodulating Peptide Thymosin Alpha 1 on Multiple Myeloma and Immune Recovery after Hematopoietic Stem Cell Transplantation The authors observed a slight reduction in the proliferation of murine and human multiple myeloma (MM) cell lines in the presence of thymosin α1 (Tα1) in vitro. However, using two immunocompetent murine MM models, they did not observe any impact of Tα1 administration on MM development in vivo. [Cancer Immunol Immunother] Abstract Common Marmoset CD117-Positive Hematopoietic Cells Possess Multipotency As stem cell factor (SCF) is an essential molecule for hematopoietic stem cell development in mice and humans, scientists focused on CD117, the SCF receptor, and examined whether CD117-expressing cells possess the hematopoietic stem/progenitor cell characteristics of newborn marmoset-derived hematopoietic cells that can develop into T cells and B cells. [Int Immunol] Abstract CLINICAL RESEARCH Inducible Caspase-9 Suicide Gene Controls Adverse Effects from Alloreplete T Cells after Haploidentical Stem Cell Transplantation To test the feasibility of a single T-cell manipulation to eliminate alloreactivity while sparing antiviral and antitumor T cells, investigators infused 12 haploidentical hematopoietic stem cell transplant patients with increasing numbers of alloreplete haploidentical T cells expressing the inducible caspase 9 suicide gene. [Blood] Abstract | Press Release Reproducibility and Prognostic Significance of Morphologic Dysplasia in De Novo Acute Myeloid Leukemia Researchers performed an in-depth analysis of morphologic dysplasia in 159 de novo acute myeloid leukemia cases lacking myelodysplasia-related cytogenetic abnormalities. [Mod Pathol] Abstract Quality of the Hematopoietic Stem Cell Graft Affects the Clinical Outcome of Allogeneic Stem Cell Transplantation The authors studied the impact of graft quality on clinical outcome and identify factors affecting graft quality. They investigated the influence of graft quality on the clinical outcome in 144 hematopoietic stem cell transplantation patients. [Transfusion] Abstract |