Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells Researchers showed that Runx1-deficient hematopoietic stem and progenitor cells have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis. [Cell Stem Cell] Abstract | Graphical Abstract Leukemic Marrow Infiltration Reveals a Novel Role for Egr3 as a Potent Inhibitor of Normal Hematopoietic Stem Cell Proliferation The authors used a robust non-irradiated mouse model of human MLL-AF9 leukemia to examine the suppression of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells during leukemia cell expansion in vivo. Gene expression profiling and further functional validation revealed that Egr3 was a strong limiting factor for the proliferative potential of HSCs. [Blood] Abstract Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2 Scientists showed that nitrogen permease regulator-like 2 (NPRL2) is required for mouse viability and that its absence significantly compromised fetal liver hematopoiesis in developing embryos. [Cell Rep] Full Article | Graphical Abstract Deficiency of the Ribosome Biogenesis Gene Sbds in Hematopoietic Stem and Progenitor Cells Causes Neutropenia in Mice by Attenuating Lineage Progression in Myelocytes Researchers established the first mammalian model of neutropenia in Shwachman-Diamond syndrome through targeted downregulation of Sbds in hematopoietic stem and progenitor cells expressing the myeloid transcription factor CCAAT/enhancer binding protein α. [Haematologica] Abstract | Full Article Autophagy Confers DNA Damage Repair Pathways to Protect the Hematopoietic System from Nuclear Radiation Injury Investigators observed that ex vivo autophagy activation reversed the proliferation inhibition, apoptosis, and DNA damage in irradiated hematopoietic cells. [Sci Rep] Full Article Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal Scientists showed that a noncanonical Wnt receptor, Frizzled-6, regulates hematopoietic stem/progenitor cell expansion and survival in a hematopoietic cell-intrinsic manner. [J Immunol] Abstract The Drosophila Histone Demethylase dKDM5/LID Regulates Hematopoietic Development The authors report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Their results showed that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. [Dev Biol] Abstract CLINICAL RESEARCH Stem Cell Transplantation in Severe Congenital Neutropenia: An Analysis from the European Society for Blood and Marrow Transplantation Investigators report on the outcome of 136 severe congenital neutropenia patients who underwent hematopoietic stem cell transplantation between 1990 and 2012 in European and Middle East centers. [Blood] Abstract Metabolic Syndrome in Adults Who Received Hematopoietic Stem Cell Transplantation for Acute Childhood Leukemia: An LEA Study Researchers evaluated prospectively the incidence and risk factors of the metabolic syndrome and its components in 170 adult patients who received an hematopoietic stem cell transplantation for childhood. [Bone Marrow Transplant] Abstract FLT3 Mutational Status Is an Independent Risk Factor for Adverse Outcomes after Allogeneic Transplantation in AML The authors investigated FMS-like tyrosine kinase-3 (FLT3) mutational status on transplant outcomes. They conducted a retrospective cohort study of 262 consecutive AML patients who underwent first-time allogeneic hematopoietic cell transplantation, of whom 171 had undergone FLT3-internal tandem duplication mutational testing. [Bone Marrow Transplant] Abstract |