BMP Signaling Differentially Regulates Distinct Hematopoietic Stem Cell Types Investigators showed that hematopoietic stem cells in murine fetal liver and the bone marrow are of two types that can be prospectively isolated—BMP activated and non-BMP activated. [Nat Commun] Full Article The tRNA Methyltransferase Dnmt2 Is Required for Accurate Polypeptide Synthesis during Hematopoiesis Scientists showed that endochondral ossification is delayed in newborn Dnmt2-deficient mice, which was accompanied by a reduction of the hematopoietic stem and progenitor cell population and a cell-autonomous defect in their differentiation. [EMBO J] Full Article | Graphical Abstract Antibodies Targeting Human IL1RAP (IL1R3) Show Therapeutic Effects in Xenograft Models of Acute Myeloid Leukemia The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of acute myeloid leukemia patients, but not on normal hematopoietic stem cells. Investigators showed that monoclonal antibodies targeting IL1RAP had strong antileukemic effects in xenograft models of human AML. [Proc Natl Acad Sci USA] Abstract | Full Article Estrogen Deficiency Heterogeneously Affects Tissue Specific Stem Cells in Mice Ovariectomy significantly increased the numbers of c-kit-positive hematopoietic stem/progenitor cells in bone marrow, but impaired their capacity to grow mixed cell-type colonies in vitro. [Sci Rep] Full Article Hierarchal Autophagic Divergence of Hematopoietic System Using conditional mouse models to create strategic defects in the hematopoietic hierarchy, the authors showed that recovery capacities in stem cells and somatic cells differed if autophagy is impaired or flawed. [J Biol Chem] Abstract | Full Article Autophagy Limits Proliferation and Glycolytic Metabolism in Acute Myeloid Leukemia Researchers demonstrated that loss of Atg5 resulted in an identical hematopoietic stem and progenitor cell (HSPC) phenotype as loss of Atg7, confirming a general role for autophagy in HSPC regulation. [Cell Death Disc] Full Article CLINICAL RESEARCH Clofarabine Salvage Therapy Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory AML Researchers studied the safety and efficacy of clofarabine-based salvage therapy. The study was designed as a Phase II, multi-center, intent-to-transplant study. [Leukemia] Abstract Allogeneic Hematopoietic Stem Cell Transplantation for Mitochondrial Neurogastrointestinal Encephalomyopathy Investigators conducted a retrospective analysis of all known patients suffering from mitochondrial neurogastrointestinal encephalomyopathy who underwent allogeneic hematopoietic stem cell transplantation between 2005 and 2011. [Brain] Abstract |