Hematopoiesis News Volume 6.33 | Aug 25 2015

Dipeptide Species Regulate p38MAPK-Smad3 Signaling to Maintain Chronic Myelogenous Leukemia Stem Cells
The authors surveyed global metabolic differences between murine normal hematopoietic stem cells (HSCs) and chronic myelogenous leukemia (CML) stem cells using metabolomics techniques. They showed that CML stem cells accumulate significantly higher levels of certain dipeptide species than normal HSCs. [Nat Commun] Full Article

FOXF1 Inhibits Hematopoietic Lineage Commitment during Early Mesoderm Specification
Researchers revealed that FOXF1-expressing mesoderm was derived from FLK1⁺ progenitors and that in vitro this transcription factor was expressed in smooth muscle and transiently in endothelial lineages but not in hematopoietic cells. [Development] Abstract

Targeting BTK for the Treatment of FLT3-ITD Mutated Acute Myeloid Leukemia
Researchers placed the FMS-like-tyrosine-kinase-3 (FLT3)-ITD upstream of Bruton’s tyrosine kinase (BTK) in acute myeloid leukemia (AML) and showed that the BTK inhibitor ibrutinib inhibited the survival and proliferation of FLT3-ITD primary AML blasts and AML cell lines. [Sci Rep] Full Article

Salarin C Inhibits Maintenance of Hypoxia-Selected Chronic Myeloid Leukemia Progenitor Cells
Salarin C, an anticancer macrolide extracted from the Fascaplysinopsis sponge, was tested for its activity on chronic myeloid leukemia cells, especially after their incubation in atmosphere at 0.1% oxygen. Salarin C induced mitotic cycle arrest, apoptosis and DNA damage. [Cell Cycle] Abstract

Olive Leaf Components Apigenin 7-Glucoside and Luteolin 7-Glucoside Direct Human Hematopoietic Stem Cell Differentiation towards Erythroid Lineage
Main olive leaf phytochemicals oleuropein, apigenin 7-glucoside and luteolin 7-glucoside were investigated for their potential effects on hematopoietic stem cell differentiation using both phenotypic and molecular analysis. [Differentiation] Abstract

Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow
Scientists generated hematopoietic- and endothelial cell-specific Prep1-deficient mice and demonstrated that expression of Prep1 in the hematopoietic cell compartment is not essential for either embryonic or adult hematopoiesis, although its absence caused significant hematopoietic abnormalities in the adult bone marrow. [PLoS One] Full Article

CLINICAL RESEARCH

Contribution of Chemotherapy Mobilization to Disease Control in Multiple Myeloma Treated with Autologous Hematopoietic Cell Transplantation
In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). Investigators compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-HCT in the US and Canada between 2007 and 2012. [Bone Marrow Transplant] Abstract

Numerical Impairment of Nestin⁺ Bone Marrow Niches in Acute GvHD after Allogeneic Hematopoietic Stem Cell Transplantation for AML
To investigate whether acute GvHD reduces the number of nestin⁺ perivascular bone marrow stem cell niches, researchers examined patients with AML who had undergone allogeneic hematopoietic stem cell transplantation. [Bone Marrow Transplant] Abstract

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NYBC Partners with UC Davis Health System to Produce More Viable Stem Cell Therapies
New York Blood Center (NYBC) announced a new collaboration with the University of California, Davis, Health System to manufacture specialized lines of stem cells as potential therapies for repair and regeneration of retina, kidney, lung and liver tissue, as well as for the treatment of neurodegenerative disorders such as Parkinson’s, Alzheimer’s and Huntington’s disease. [New York Blood Center] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Regulatory Coordinator – Leukemia (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Hematologic Malignancies (Northwestern University)

Postdoctoral Research Associate – Pharmacogenomics (St. Jude Children’s Research Hospital)

Postdoctoral Fellow – Hematopoiesis (University Hospital of Cologne)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Research Associate – Cell Biology (Editas Medicine)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

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