Minimal PU.1 Reduction Induces a Preleukemic State and Promotes Development of Acute Myeloid Leukemia Scientists assessed functional consequences of modest reductions in PU.1 expression on leukemia development in mice harboring DNA lesions resembling those acquired during human stem cell aging. [Nat Med] Abstract Wnt Signaling Induces Transcription, Spatial Proximity and Translocation of Fusion Gene Partners in Human Hematopoietic Cells Investigators report that Wnt/β-catenin signaling increased the expression of ETO and RUNX1 genes in human hematopoietic progenitors. [Blood] Abstract Bone Marrow Failure and Developmental Delay Caused by Mutations in Poly(Archive)-Specific Ribonuclease (PARN) Genomic, biochemical and knockdown experiments in human marrow cells and in zebrafish were performed to clarify the role of PARN in human disease. Knocking down PARN in human marrow cells and zebrafish impaired hematopoiesis. [J Med Genet] Abstract PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche Scientists showed the relevance of the protein tyrosine phosphatase PTPN13 and β-catenin as intracellular signaling molecules to control hematopoietic stem cell adhesiveness, cell cycling, and quiescence. [Stem Cell Reports] Abstract | Graphical Abstract Malat1 as an Evolutionarily Conserved LncRNA, Plays a Positive Role in Regulating Proliferation and Maintaining Undifferentiated Status of Early-Stage Hematopoietic Cells After treating erythroid myeloid lymphoid (EML) cells with all-trans retinoic acid (ATRA), researchers investigated the expression and regulation of Malat1 during hematopoietic differentiation, the results showed that ATRA significantly down regulates Malat1 expression during the differentiation of EML cells. [BMC Genomics] Full Article High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells Investigators conducted high-throughput small-interfering-RNA (siRNA) library screening and showed that YN-1, a human erythroleukemia cell line, expressed high levels of GATA-2 following the activation of the hematopoietic-specific 1S promoter. [PLoS One] Full Article CLINICAL RESEARCH Role of HMGB1 in Regulation of STAT3 Expression in CD4+ T Cells from Patients with aGVHD after Allogeneic Hematopoietic Stem Cell Transplantation The authors found that the expression of HMGB1 and STAT3 were higher in CD4+ T cells of patients with acute graft-versus-host disease (aGVHD) compared with those without aGVHD, and the HMGB1 expression was positively correlated with STAT3 expression. [Clin Immunol] Abstract Treatment with Hypomethylating Agents before Allogeneic Stem Cell Transplant Improves Progression Free Survival for Patients with Chronic Myelomonocytic Leukemia Researchers retrospectively reviewed the data for 83 consecutive patients with chronic myelomonocytic leukemia who received an allogeneic stem cell transplant to identify factors associated with improved survival and determined whether treatment with hypomethylating agents before transplant improves progression-free survival. [Biol Blood Marrow Transplant] Abstract Haploidentical T-Cell Replete Transplantation with Post-Transplant Cyclophosphamide for Patients in or above the 6th Decade of Age Compared with Allogeneic Hematopoietic Stem Cell Transplantation from an HLA-Matched Related or Unrelated Donor Investigators transplanted 31 patients over the age of 55 years from a haploidentical donor and compared their outcome with same-age patients transplanted from a matched-related or an unrelated donor. [Biol Blood Marrow Transplant] Abstract Clinical Impact of Hematogones on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation Patients undergoing allo-BMT from related donors were more likely to develop hematogones (HGs) at day 30 compared to unrelated donors. Patients undergoing allo-BMT from HLA-mismatched donors were less likely to develop HGs at day 30. [Ann Hematol] Abstract |