G Protein-Coupled Receptor 183 Facilitates Endothelial-to-Hematopoietic Transition via Notch1 Inhibition Scientists showed that G protein-coupled receptor 183 signaling serves as an indispensable switch for hematopoietic stem and progenitor cell emergence by repressing Notch signaling before the onset of endothelial-to-hematopoietic transition. [Cell Res] Full Article Overexpression and Knockout of miR-126 Both Promote Leukemogenesis through Targeting Distinct Gene Signaling Researchers showed that both overexpression and knockout of miR-126 result in enhanced leukemogenesis in cooperation with t(8;21) fusion genes, AML1-ETO/RUNX1-RUNX1T1 or AML1-ETO9a. [Blood] Abstract The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness Scientists investigated the role of STS1 and STS2 on FLT3 and c-KIT phosphorylation, activity, and function in normal and stress-induced hematopoiesis. [Stem Cell Reports] Full Article | Graphical Abstract GATA2 Regulates Wnt Signaling to Promote Primitive Red Blood Cell Fate Investigators showed that up-regulation of canonical Wnt signaling during gastrulation blocks commitment to a hematopoietic fate while down-regulation of non-canonical Wnt signaling impairs erythroid differentiation. [Dev Biol] Abstract FANCA Safeguards Interphase and Mitosis during Hematopoiesis In Vivo Scientists quantified the origins of genomic instability in Fanconi anemia (FA) patients and mice in vivo and ex vivo. They found that both mitotic errors and interphase DNA damage significantly contribute to genomic instability during FA-deficient hematopoiesis and in non-hematopoietic human and murine FA primary cells. [Exp Hematol] Abstract | Full Article Follistatin-Like 1 Attenuates Differentiation and Survival of Erythroid Cells through Smad2/3 Signaling Scientists report that follistatin-like 1 (FSTL1) treatment impairs hemin-induced erythroid differentiation and cell survival. FSTL1 differentially regulated transforming growth factor beta and bone morphogenetic protein signaling. [Biochem Biophys Res Commun] Full Article CLINICAL RESEARCH Efficacy and Safety of Deferasirox in Non-Thalassemic Patients with Elevated Ferritin Levels after Allogeneic Hematopoietic Stem Cell Transplantation A multicenter DE02 trial assessed the safety, efficacy and impact of deferasirox on iron homeostasis after allogeneic hematopoietic stem cell transplantation. [Bone Marrow Transplant] Abstract UGT2B17 Minor Histocompatibility Mismatch and Clinical Outcome after HLA-Identical Sibling Donor Stem Cell Transplantation The authors retrospectively studied the clinical impact of a UGT2B17 mismatch in a cohort of 1127 patients receiving a hematopoietic stem cell transplantation from an HLA-identical sibling donor. [Bone Marrow Transplant] Abstract |