Hematopoiesis News Volume 6.45 | Nov 17 2015

CLEC-2 in Megakaryocytes Is Critical for Maintenance of Hematopoietic Stem Cells in the Bone Marrow
The authors identified C-type lectin-like receptor-2 (CLEC-2) signaling as a novel molecular mechanism mediating the production of thrombopoietin and other factors for the maintenance of hematopoietic stem cells. [J Exp Med] Abstract

The Role of CD44 in Fetal and Adult Hematopoietic Stem Cell Regulation
Using a CD44^-/- mouse model, conserved functional roles of CD44 are revealed throughout development: CD44 is critical in the maintenance of hematopoietic stem and progenitor pools, as well as in hematopoietic stem cell migration. [Haematologica] Abstract | Full Article

Primary Myeloma Interaction and Growth in Coculture with Healthy Donor Hematopoietic Bone Marrow
Researchers established an interactive healthy donor whole bone marrow (BM) based culture system capable of maintaining prolonged survival of primary human primary myeloma cells. This normal BM coculture system was different from using autologous BM that is already affected by the disease. [BMC Cancer] Full Article

SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukemia Maintenance
Investigators explored the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukemia. They observed the selective requirement for these proteins for leukemic cell expansion and self-renewal in-vitro as well as in leukemia. [PLoS One] Full Article

LPS-Stimulated Human Bone Marrow Stroma Cells Support Myeloid Cell Development and Progenitor Cell Maintenance
Scientists showed that in addition to enhanced myeloid colony formation from human CD34⁺ cells, lipopolysaccharide (LPS) stimulation retains overall higher numbers of CD34⁺ cells in co-culture assays using bone marrow stromal cells, with eightfold more CD34⁺ cells that underwent up to three divisions as compared to non-stimulated assays. [Ann Hematol] Abstract

Role of Neuropeptide Y in the Bone Marrow Hematopoietic Stem Cell Microenvironment
Researchers demonstrated that neuropeptide Y deficient mice have significantly reduced hematopoietic stem cell numbers and impaired bone marrow regeneration due to apoptotic destruction of sympathetic nervous system fibers and/or endothelial cells. [BMB Rep] Abstract | Download Full Article

CLINICAL RESEARCH

Addition of Sorafenib versus Placebo to Standard Therapy in Patients Aged 60 Years or Younger with Newly Diagnosed Acute Myeloid Leukemia (SORAML): A Multicenter, Phase II, Randomized Controlled Trial
The authors investigated the efficacy and tolerability of sorafenib versus placebo in addition to standard chemotherapy in patients with acute myeloid leukemia aged 60 years or younger. [Lancet Oncol] Abstract

Thiotepa-Based High-Dose Therapy for Autologous Stem Cell Transplantation in Lymphoma: A Retrospective Study from the EBMT
Investigators evaluated potential risks and benefits of thiotepa-based preparative regimens compared with BEAM (carmustine, etoposide, cytarabine, melphalan) in auto-stem cell transplantation for diffuse large B-cell lymphoma, follicular lymphoma or Hodgkin lymphoma. [Bone Marrow Transplant] Abstract

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Infinity Announces Completion Of Target Enrollment in DUO™, A Phase III Study Evaluating Duvelisib in Chronic Lymphocytic Leukemia
Infinity Pharmaceuticals, Inc. announced that it has reached target enrollment of 300 patients in DUO™, a randomized Phase III monotherapy study evaluating the safety and efficacy of duvelisib compared to ofatumumab in patients with relapsed or refractory chronic lymphocytic leukemia. [Infinity Pharmaceuticals, Inc.] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Cardiovascular/Hematopoietic Development (Kumamoto University)

Postdoctoral Fellow – Leukemia Research (City of Hope)

Postdoctoral Position – Stem Cells and Leukemia (Florida State University)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Postdoctoral Research Fellow – Medicinal Chemistry for Cancer Drug Discovery (University of Michigan)

Research Technician – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – iPSC Models of Hematologic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Positions – Cancer and Developmental Biology (North Carolina Central University)

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