Targeting Casein Kinase II Restores Ikaros Tumor Suppressor Activity and Demonstrates Therapeutic Efficacy in High-Risk Leukemia Investigators showed that Ikaros function is impaired by the pro-oncogenic casein kinase II (CK2), and that CK2 is overexpressed in leukemia. CK2 inhibition restores Ikaros function as transcriptional repressor of cell cycle and phosphatidylinositol-3 kinase pathway genes, resulting in an antileukemia effect. [Blood] Abstract | Press Release Brca1 Deficiency Causes Bone Marrow Failure and Spontaneous Hematologic Malignancies in Mice The authors showed that loss of Brca1 in murine bone marrow causes hematopoietic defects similar to that seen in people with Fanconi anemia. [Blood] Abstract CBP/Catenin Antagonist Safely Eliminates Drug-Resistant Leukemia-Initiating Cells Researchers demonstrated that specifically inhibiting the interaction between CREB-binding protein (CBP) and catenin with ICG-001 results in the differentiation of quiescent drug-resistant chronic myelogenous leukemia-initiating cells, thereby sensitizing them to BCR-ABL tyrosine kinase inhibitors. [Oncogene] Abstract Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs Using a combination of DNA mutation indicator assays, researchers observed a 2- to 3-fold increase in the number of DNA mutations in the hematopoietic system upon aging. [Cell Rep] Full Article | Graphical Abstract Fancb Deficiency Impairs Hematopoietic Stem Cell Function Scientists investigated hematopoiesis in adult Fancb deficient (Fancb-/y) mice and found that Fancb-/y mice have decreased hematopoietic stem cell quiescence accompanied by reduced progenitor activity in vitro and reduced repopulating capacity in vivo. [Sci Rep] Full Article Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells Investigators examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model. Fetal liver hematopoietic stem cells were more susceptible to etoposide than maternal bone marrow mononuclear cells. [PLoS One] Full Article CLINICAL RESEARCH Ibrutinib Combined with Bendamustine and Rituximab Compared with Placebo, Bendamustine, and Rituximab for Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (HELIOS): A Randomized, Double-Blind, Phase III Study The authors assessed the efficacy and safety of adding ibrutinib, an oral covalent inhibitor of Bruton’s tyrosine kinase, to bendamustine plus rituximab in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma. [Lancet Oncol] Abstract Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults with Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study Scientists evaluated the efficacy of pediatric-like acute lymphoblastic leukemia therapy in adults with lymphoblastic lymphoma. [J Clin Oncol] Abstract Inotuzumab Ozogamicin in the Management of Acute Lymphoblastic Leukemia Researchers analyzed changes in patient profile, transplantation, graft characteristics and outcome among 250 children and adolescent patients who received allogeneic stem cell transplantation in a single center. [Bone Marrow Transplant] Abstract |