Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia Scientists provide experimental evidence for the functional involvement and therapeutic potential of targeting PRMT1, an H4R3 methyltransferase, in various MLL and non-MLL leukemias. [Cancer Cell] Full Article | Graphical Abstract Hematopoietic ESL-1 Enables Stem Cell Proliferation in the Bone Marrow by Limiting TGFβ Availability The authors report a cell-intrinsic mechanism whereby hematopoietic cells limit proliferation within the bone marrow, and showed that this pathway is repressed by E-selectin ligand 1 (ESL-1). Mice deficient in ESL-1 displayed aberrant hematopoietic stem and progenitor cells quiescence, expansion of the immature pool and reduction in niche size. [Nat Commun] Full Article Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis To investigate how Dnmt3b-mediated DNA methylation affects leukemogenesis, investigators analyzed leukemia development under conditions of high and physiological methylation levels in a tetracycline-inducible knock-in mouse model. [Blood] Abstract PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease The authors demonstrated that co-expression of PBX3 and MEIS1, without ectopic expression of a HOX gene, is sufficient for transformation of normal mouse hematopoietic stem/progenitor cells in vitro. [Cancer Res] Abstract PUMA Promotes Apoptosis of Hematopoietic Progenitors Driving Leukemic Progression in a Mouse Model of Myelodysplasia Researchers examined the role of p53 and its pro-apoptotic effectors, PUMA and NOXA in NHD13 mice. The absence of p53 or PUMA but not NOXA reduced apoptosis and expanded the numbers of myelodysplastic syndrome-repopulating cells. [Cell Death Differ] Abstract The DNA-Damage Response Gene GADD45A Induces Differentiation in Hematopoietic Stem Cells without Inhibiting Cell Cycle or Survival Investigators revealed the changes in murine hematopoietic stem cell (HSC) fate control orchestrated by the expression of growth arrest and DNA-damage-inducible 45 alpha (GADD45A) at single cell resolution. In contrast to other cellular systems, GADD45A expression did not cause a cell cycle arrest or an alteration in the decision between cell survival and apoptosis in HSCs. [Stem Cells] Abstract miR-133 Regulates Evi1 Expression in AML Cells as a Potential Therapeutic Target Scientists screened microRNAs which down-regulate ecotropic viral integration site 1 (Evi1). miR-133 increased drug sensitivity specifically in Evi1 expressing leukemic cells, but not in Evi1-non-expressing cells. [Sci Rep] Full Article CLINICAL RESEARCH Adverse Reactions during Stem Cell Infusion in Children Treated with Autologous and Allogeneic Stem Cell Transplantation Researchers retrospectively studied pediatric patients undergoing autologous and allogeneic hematopoietic stem cell transplantation to determine the incidence and grade of adverse reactions during stem cell infusion and their predictors. [Bone Marrow Transplant] Abstract Long-Term Follow-Up of Therapy-Related Myelodysplasia and AML Patients Treated with Allogeneic Hematopoietic Cell Transplantation The authors performed a retrospective single-center study to assess changes in outcomes after allo-hematopoietic stem cell transplantation and causes of non-relapse mortality over three five-year periods. [Bone Marrow Transplant] Abstract |