Histone Demethylase KDM2B Regulates Lineage Commitment in Normal and Malignant Hematopoiesis Scientists identified histone demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and progenitor cells. [J Clin Invest] Full Article Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function The authors investigated targetable cellular and molecular abnormalities in leukemia marrow stroma responsible for the suppression of normal hematopoiesis using a T-ALL mouse model and human T-ALL xenografts. [Cancer Res] Abstract High Expression of Connective Tissue Growth Factor Accelerates Dissemination of Leukemia Researchers genetically engineered leukemia cells to modulate connective tissue growth factor (CTGF) expression levels. Elevated CTGF levels accelerated disease dissemination and reduced survival in NOD/SCID mice. [Oncogene] Abstract Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells Investigators applied single-cell RNA-sequencing to a population of hematopoietic cells in zebrafish as they undergo thrombocyte lineage commitment. [Cell Rep] Full Article | Graphical Abstract RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis Runx1 has two promoters P1 (distal) and P2 (proximal), which generate distinct protein isoforms. Utilizing a dual reporter mouse model, researchers demonstrated that the distal P1 promoter is broadly active in adult hematopoietic stem and progenitor cell populations. [PLoS Genet] Full Article H2AX Deficiency Is Associated with Erythroid Dysplasia and Compromised Hematopoietic Stem Cell Function The authors used a genetically modified mouse model and human patient data to examine the physiological roles of H2AX in hematopoiesis and how the loss of H2AX contributes to dyserythropoiesis in myelodysplastic syndromes. [Sci Rep] Full Article CLINICAL RESEARCH TP53 Mutation in Patients with High-Risk Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation Investigators studied the impact of TP53 mutations on the outcome of acute myeloid leukemia patients with adverse cytogenetic risk treated with allogeneic hematopoietic stem cell transplantation. [Br J Haematol] Abstract TCR-Alpha/Beta and CD19 Depletion and Treosulfan-Based Conditioning Regimen in Unrelated and Haploidentical Transplantation in Children with Acute Myeloid Leukemia The authors evaluated the depletion of TCR-alpha/beta cells from the graft of children with high-risk AML, who received transplantation from unrelated and haploidentical donors. [Bone Marrow Transplant] Abstract Comparable Outcomes between Autologous and Allogeneic Transplant for Adult Acute Myeloid Leukemia in First CR Investigators retrospectively compared the outcomes of patients who underwent autologous peripheral blood stem cell transplantation (PBSCT) with those who underwent allogeneic bone marrow transplantation and allogeneic-PBSCT from HLA-matched sibling donor for adults with acute myeloid leukemia/CR1. [Bone Marrow Transplant] Abstract |