Hematopoiesis News Volume 7.05 | Feb 9 2016

BCOR Regulates Myeloid Cell Proliferation and Differentiation
Investigators explored the function of BCOR in myeloid cells using myeloid murine models with Bcor conditional loss-of-function or overexpression alleles. Bcor mutant bone marrow cells showed significantly higher proliferation and differentiation rates with upregulated expression of Hox genes. [Leukemia] Abstract

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes
Researchers investigated the consequences of inhibiting lysine specific demethylase 1 (KDM1A) in a panel of cell lines representing all acute myeloid leukemia subtypes using selective, reversible and irreversible KDM1A small molecule inhibitors. [Cancer Res] Abstract

The Slicer Endonuclease Argonaute 2 is a Negative Regulator of Hematopoietic Stem Cell Quiescence
To identify the functions of the slicer endonuclease Argonaute (Ago) 2 in the physiology of hematopoietic stem cells (HSCs), scientists generated Ago2^Hem-KO mice, that are deficient for Ago2 in HSCs and in their progeny. [Stem Cells] Abstract

FYN Expression Potentiates FLT3-ITD Induced STAT5 Signaling in Acute Myeloid Leukemia
The authors studied the role of FYN in FLT3 signaling in respect to acute myeloid leukemia. They observed that FYN displays a strong association with wild-type FLT3 as well as oncogenic FLT3-ITD and is dependent on the kinase activity of FLT3 and the SH2 domain of FYN. [Oncotarget] Full Article

miR-203 Inhibits Proliferation and Self-Renewal of Leukemia Stem Cells by Targeting Survivin and Bmi-1
Investigators found that miR-203 expression was down-regulated in CD34⁺ AML cells as compared with CD34^– cells isolated from patients as well as in leukemia stem cells-enriched (CD34⁺ CD38^–) cell lines KG-1a or MOLM13. [Sci Rep] Full Article

Depletion of SAM50 Specifically Targets BCR-ABL-Expressing Leukemic Stem and Progenitor Cells by Interfering with Mitochondrial Functions
Scientists observed that human leukemic cells display a specific dependency on SAM50 expression, as downregulation of SAM50 in BCR-ABL-expressing, but not normal CD34⁺ human hematopoietic stem and progenitor cells caused a significant decrease in growth, colony formation, and replating capacity. [Stem Cells Dev] Abstract

CLINICAL RESEARCH

Allogeneic Hematopoietic Cell Transplantation as Curative Therapy for Non-Transformed Follicular Lymphomas
The authors identified subgroups of follicular lymphoma (FL) patients who benefit from hematopoietic cell transplantation (HCT). HCT for FL was associated with acceptable non-relapse mortality, and offers a substantial chance of cure for patients with refractory disease or advanced age. [Bone Marrow Transplant] Abstract

A Reduced Intensity Conditioning Regimen for Patients with Dyskeratosis Congenita Undergoing Hematopoietic Stem Cell Transplantation
Researchers report their experience in seven patients with dyskeratosis congenita who underwent allogeneic transplant using a reduced intensity conditioning preparative regimen that contained chemotherapy only. [Biol Blood Marrow Transplant] Abstract

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Terry Fox Award Helps Ottawa Researcher Develop Next-Generation Cancer Immunovirotherapy
The Terry Fox Research Institute has awarded Dr. Guy Ungerechts (The Ottawa Hospital and the University of Ottawa) a $450,000 New Investigator grant to develop innovative new treatments to destroy cancer cells and stimulate a patient’s own immune system to attack tumors, while leaving healthy tissues unharmed. [Terry Fox Research Institute] Press Release

ADC Therapeutics Doses First Patient in Phase I Trial of ADCT-301 Trial in Acute Myeloid Leukemia
ADC Therapeutics SA (ADCT) announced that the first patient has been dosed in a Phase I trial to evaluate its lead antibody drug conjugate (ADC) ADCT-301 in Acute Myeloid Leukemia. [ADC Therapeutics SA (Business Wire)] Press Release

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Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford Burnham Prebys Medical Discovery Institute)

Postdoctoral Researcher – Pre-Leukemic Stem Cells in the Thymus (Ghent University)

Laboratory Technician – Molecular Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Stem Cell Biology (Krembil Research Institute)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

Postdoctoral Fellow – Leukemia Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Epigenetics and RNA Splicing (National Cancer Institute)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

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