Hematopoiesis News Volume 7.31 | Aug 9 2016

TOP STORY

BRPF1 Is Essential for Development of Fetal Hematopoietic Stem Cells

Scientists investigated the function of bromodomain- and PHD finger-containing protein 1 (BRPF1) in hematopoiesis by selectively deleting its gene in murine blood cells. Brpf1-deficient pups experienced early lethality due to acute bone marrow failure and aplastic anemia. [J Clin Invest] Full Article

(Ranked by impact factor of the journal)

LTβR Controls Thymic Portal Endothelial Cells for Hematopoietic Progenitor Cell Homing and T-Cell Regeneration

Using conditional gene-deficient mice, investigators found that lymphotoxin beta receptor (LTβR) directly controls thymic endothelial cells to guide hematopoietic progenitor cells homing. [Nat Commun] Full Article

The Rate of Protein Synthesis in Hematopoietic Stem Cells Is Limited Partly by 4E-BPs

Adult stem cells must limit their rate of protein synthesis, but the underlying mechanisms remain largely unexplored. Differences in protein synthesis among hematopoietic stem cells and progenitor cells did not correlate with differences in proteasome activity, total RNA content, mRNA content, or cell division rate. [Genes Dev] Abstract | Full Article

Rictor Plays a Pivotal Role in Maintaining Quiescence as Well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia

Scientists demonstrated that Rictor is essential for the maintenance of MLL-driven leukemia by preventing LSCs from exhaustion. [Leukemia] Abstract

Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells

Researchers demonstrated that transforming growth factor β is required for hematopoietic stem and progenitor cells specification and that it regulates the expression of the Notch ligand Jagged1a in endothelial cells prior to endothelial-to-hematopoietic transition, in a striking parallel with the epithelial-to-mesenchymal transition. [Dev Cell] Full Article | Graphical Abstract

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-Catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia

Scientists examined the interplay between NF-κB and FOXM1/β-catenin, and the effect of its chemical intervention on chronic myelogenous leukemia stem cells. [Clin Cancer Res] Abstract

Hemopedia: An Expression Atlas of Murine Hematopoietic Cells

Researchers present Hemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. [Stem Cell Reports] Full Article | Graphical Abstract

Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy

Investigators present data comparing the clinical characteristics of poor versus non-poor mobilizing donors and the results of panel-based sequencing of hematopoietic genes in poor mobilizing donors. [Biol Blood Marrow Transplant] Abstract

Acute Leukemia and Myelodysplastic Syndromes with Chromosomal Rearrangement Involving 11q23 Locus, but Not MLL Gene

Little is known of hematopoietic neoplasms associated with 11q23 translocation but without MLL rearrangement (11q23⁺/MLL^–). Scientists characterized such cases with 11q23⁺/MLL^–. [J Clin Pathol] Abstract

CLINICAL RESEARCH

The Impact of HLA-Matching on Reduced Intensity Conditioning Regimen Unrelated Donor Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Patients Above 50 Years-A Report from the EBMT Acute Leukemia Working Party

Researchers retrospectively compared the outcome of 3398 patients above the age of 50 years who underwent 10/10 matched-unrelated-donor, 9/10, or 8/10 mismatched-unrelated-donor allogeneic hematopoietic stem cell transplant for acute myeloid leukemia after reduced intensity conditioning regimen between 2000 and 2013. [J Hematol Oncol] Full Article

Subpopulations of T Regulatory Cells in Blood Stem Cell Harvests Influence Development of Acute Graft vs. Host Disease in Allogeneic Transplant Recipients

Scientists analyzed regulatory T cell subpopulations in hematopoietic stem cell harvests from 22 allogeneic (matched unrelated and sibling) donors with flow cytometry by their expression of CD45RA, CD127, CD25, and FoxP3 marker combinations. [Cytometry B Clin Cytom] Abstract

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles

The authors discuss the specific applications of gene-editing technologies in human hematopoietic stem and progenitor cells, as informed by prior experience with gene addition strategies. [Hum Gene Ther] Abstract

Chromatin Programming by Developmentally-Regulated Transcription Factors: Lessons from the Study of Hematopoietic Stem-Cell Specification and Differentiation

The authors summarize the current knowledge on the mechanism of action of TFs regulating hematopoietic stem-cell specification and differentiation, and place this information into the context of general principles governing development. [FEBS Lett] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Bellicum Announces BPX-501 European Regulatory Updates

Bellicum Pharmaceuticals, Inc. announced that the European Commission has granted orphan drug designations for both its lead T-cell therapy product candidate BPX-501 for treatment in hematopoietic stem cell transplantation, and for activator agent rimiducid for the treatment of graft vs. host disease. [Bellicum Pharmaceuticals, Inc.] Press Release

Crown Bioscience Announces the Completion of Over 100 Blood Cancer Studies

Crown Bioscience announced the milestone of completing 110 client projects on blood cancer treatments using models from their HuKemia^® collection. [Crown Bioscience] Press Release

Actinium Pharmaceuticals Granted SME Status by the European Medicines Agency; Reiterates Focus on EU Market

Actinium Pharmaceuticals, Inc. announced that the company has been granted Small and Medium-Sized Enterprise (SME) status by the European Medicines Agency. [Actinium Pharmaceuticals, Inc.] Press Release

Russian Scientists Bracing for Massive Job Losses

Russia’s scientific community is reeling from news that the government plans to fire about 10,000 researchers over the next three years. [ScienceInsider] Editorial

The FDA Is Prohibited from Going Germline

A potentially renewable provision of the Consolidated Appropriation Act of 2016 forestalling the prospect of human germline modification was signed into law on December 18th, 2015. The provision has since been incorporated again into the House and Senate appropriation bills for the fiscal year. [ScienceInsider] Editorial

US Agency Lifts Ban on Funding Human–Animal Hybrids

Researchers in the United States will soon be able to resume creating chimaera-based projects. [Nature News] Editorial

Beyond CRISPR: A Guide to the Many Other Ways to Edit a Genome

The zeal with which researchers jumped on a possible new gene-editing system called NgAgo earlier this year reveals an undercurrent of frustration with CRISPR–Cas9 — and a drive to find alternatives. [Nature News] Editorial

NEW International Workshop on Waldenstrom’s Macroglobulinemia & Symposium on Multiple Myeloma
October 5-8, 2016
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Scientist (National Taiwan University)

NEW Postdoctoral Fellow – Stem Cell Functions in the Hematopoietic System and Other Systems Derived from the Mesoderm (University of Illinois at Chicago)

Technical Sales Representative (STEMCELL Technologies Inc.)

Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Senior Research Assistant – Human Leukemia Stem/Progenitor Cells (The University of Texas MD Anderson Cancer Center)

Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Fellow – Molecular and Cellular Basis of Hematopoiesis (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University)

Cytogenetics Laboratory Supervisor (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (Novartis)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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