Hematopoiesis News Volume 7.34 | Aug 30 2016

TOP STORY

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

Scientists showed that classically defined hematopoietic stem cells maintain immune cell development in the steady state and during systemic cytokine responses. [Immunity] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

Scientists showed that comprehensive RNA sequencing and splice-isoform-specific PCR uncovered characteristic RNA splice isoform expression patterns that distinguished normal young and aged human stem and progenitor cells from malignant myelodysplastic syndrome and acute myeloid leukemia (AML) progenitors. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

Investigators showed that MED12, a member of the Mediator kinase module, is an essential regulator of hematopoietic stem cell (HSC) homeostasis, as in vivo deletion of Med12 causes rapid bone marrow aplasia leading to acute lethality. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract

The Immune Receptor Trem1 Cooperates with Diminished DNA Damage Response to Induce Preleukemic Stem Cell Expansion

Fanconi anemia is an inherited bone marrow failure syndrome with extremely high risk of leukemic transformation. Researchers investigated the relationship between DNA damage response and leukemogenesis using the Fanca knockout mouse model. [Leukemia] Abstract

The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9

Researchers sought to delineate the molecular mechanisms by which cohesin mutations promote enhanced hematopoietic stem and progenitor self-renewal since this represents a critical initial step during leukemic transformation. [Leukemia] Abstract

Identification of Novel Regulators of Developmental Hematopoiesis Using Endoglin Regulatory Elements as Molecular Probes

Enhancers are the primary determinants of cell identity and specific promoter/enhancer combinations of Endoglin (ENG) have been shown to target blood and endothelium in the embryo. Researchers generated a series of embryonic stem cell lines, each targeted with reporter constructs driven by specific promoter/enhancer combinations of ENG, to evaluate their discriminative potential and value as molecular probes of the corresponding transcriptome. [Blood] Abstract

Murine Tribbles Homolog 2 Deficiency Affects Erythroid Progenitor Development and Confers Macrocytic Anemia on Mice

Investigators report that Trib2 knockout mice manifest macrocytic anemia and increase of T lymphocytes. [Sci Rep] Abstract

Oncogenic STAT5 Signaling Promotes Oxidative Stress in Chronic Myeloid Leukemia Cells by Repressing Antioxidant Defenses

Scientists demonstrated that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes reactive oxygen species production by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1 (Glrx1). Downregulation of catalase and Glrx1 expression was also observed in primary cells from CML patients. [Oncotarget] Full Article

Antitumor Action of CDK Inhibitor LS-007 as a Single Agent and in Combination with ABT-199 Against Human Acute Leukemia Cells

LS-007 is a CDK inhibitor, which exhibits potent antitumor activity against chronic lymphocytic leukemia and ovarian cancer cells. Scientists further evaluated the antitumor activity of LS-007 alone and in combination with a Bcl-2 inhibitor ABT-199 in acute leukemia cells. [Acta Pharmacol Sin] Abstract

SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells

Scientists investigated the role of the SWEF proteins SWAP-70 and DEF6 in hematopoietic stem and precursor cells. [PLoS One] Full Article

CLINICAL RESEARCH

Identification of MicroRNA-Regulated Pathways Using an Integration of MicroRNA-mRNA Microarray and Bioinformatics Analysis in CD34+ Cells of Myelodysplastic Syndromes

The effect of microRNA and targeted mRNA on signal transduction is not fully understood in myelodysplastic syndromes (MDS). Investigators tried to identify the miRNAs-regulated pathways through a combination of miRNA and mRNA microarray in CD34+ cells from MDS patients. [Sci Rep] Full Article

Alternatives, and Adjuncts, to Prophylactic Platelet Transfusion for People with Hematological Malignancies Undergoing Intensive Chemotherapy or Stem Cell Transplantation

The authors determined whether agents that can be used as alternatives, or adjuncts, to platelet transfusions for people with hematological malignancies undergoing intensive chemotherapy or stem cell transplantation are safe and effective at preventing bleeding. [Cochrane Database Syst Rev] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Chugai Receives Orphan Drug Designation for Emicizumab

Chugai Pharmaceutical Co., Ltd. announced that emicizumab received orphan drug designation by the Ministry of Health, Labour and Welfare for the prevention and reduction of bleeding episodes in patients with congenital FVIII deficiency (hemophilia A) who developed inhibitors to FVIII. Emicizumab is a humanized bispecific antibody for subcutaneous injection under development for hemophilia A. [Chugai Pharmaceutical Co., Ltd.] Press Release

Emmaus Life Sciences to Seek Marketing Approval for First New Sickle Cell Disease Treatment in Nearly 20 Years; Expects to Submit New Drug Application to FDA in September

Emmaus Life Sciences, Inc. announced that it expects to submit a New Drug Application to the U.S. Food and Drug Administration (FDA) in September for the company’s treatment for sickle cell disease. [Emmaus Life Sciences] Press Release

Go Forth and Replicate!

To make replication studies more useful, researchers must make more of them, funders must encourage them and journals must publish them. [Nature] Editorial

New Leader of NIH’s Research Watchdog Faces Staff Revolt

Kathryn Partin, who took the helm of ORI in December 2015, has launched a top-to-bottom review of the office, which has been criticized for moving too slowly and meting out sanctions that lack teeth. [ScienceInsider] Editorial

South African Academics Warn of Universities on the Brink

More than 1,200 South African academics are warning that the country’s university system is at a tipping point as a result of chronic underfunding. [Nature] Editorial

NEW European Society for Medical Oncology (ESMO) 2016
October 7-11, 2016
Copenhagen, Denmark

Visit our events page to see a complete list of events in the community.

NEW PhD – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus)

NEW Postdoctoral Scholar – Tumor Biology (The Pennsylvania State University College of Medicine)

Research Technologist (Pennsylvania State University)

Technical Sales Representative (STEMCELL Technologies Inc.)

Postdoctoral Stipend – Development of Immune System (Lund University)

Principal Investigator & Clinical Geneticist – Pediatric Leukemia (Children´s Cancer Research Institute, St. Anna Kinderkrebsforschung)

Postdoctoral Research Scientist (National Taiwan University)

Postdoctoral Fellow – Stem Cell Functions in the Hematopoietic System and Other Systems Derived from the Mesoderm (University of Illinois at Chicago)

Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Senior Research Assistant – Human Leukemia Stem/Progenitor Cells (The University of Texas MD Anderson Cancer Center)

Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center)

Cytogenetics Laboratory Supervisor (Fred Hutchinson Cancer Research Center)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

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