Hematopoiesis News 7.35 September 6, 2016 | |
| |
TOP STORYScientists report that Slug, a zinc-finger transcription repressor, functions as a direct transcriptional repressor of c-Kit in hematopoietic stem cells. Conversely, stem cell factor (SCF)/c-Kit signaling positively regulates Slug through downstream c-Myc and FoxM1 transcription factors. [Leukemia] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)The authors discovered that the CK2 catalytic α and regulatory β subunits are consistently expressed in leukemia stem cells isolated from acute myeloid leukemia patients and cell lines. CK2 inactivation with the selective inhibitor CX-4945 or RNA interference induced an accumulation of leukemia stem cells in the late S–G2–M phases of the cell cycle and triggered late-onset apoptosis. [Leukemia] Abstract Researchers showed that leukocyte cell-derived chemotaxin 2 (LECT2), a multifunctional cytokine, induces hematopoietic stem cell (HSC) expansion and mobilization. Recombinant LECT2 administration results in HSC expansion in the bone marrow and mobilization to the blood via CD209a. [Nat Commun] Full Article Myeloid Leukemia with Transdifferentiation Plasticity Developing from T-Cell Progenitors Investigators report that plasticity in leukemia can result from instable lineage identity states inherited from differentiating progenitor cells. [EMBO J] Abstract | Graphical Abstract Scientists report the analysis of knock-in mice harboring the myeloid disorder-associated embryonic ectoderm development (EED) Ile363Met (I363M) mutation, analogous to the EED aromatic cage mutants. The I363M homozygotes displayed a remarkable and preferential reduction of trimethylated H3 Lys27 and died at midgestation. The heterozygotes increased the clonogenic capacity and bone marrow repopulating activity of hematopoietic stem/progenitor cells and were susceptible to leukemia. [Proc Natl Acad Sci USA] Abstract Scientists observed that imatinib and JAK inhibitor I combination restored the expression pattern of the down-regulated miRNAs in primary CML lin(−) cells. [Sci Rep] Full Article R-2-hydroxyglutarate (R-2HG) enhances NF-κB-dependent expression of cytokines including IL-6, IL-8 and complement 5a to stimulate proliferation of acute myeloid leukemia (AML) cells. In addition, R-2HG also upregulates vascular endothelial adhesion molecule 1 and CXCR4 in stromal cells to enhance the contact between AML and stromal cells and attenuates chemotherapy-induced apoptosis. [Sci Rep] Full Article Investigators used parthenolide (PTL), an agent shown to target critical mechanisms of redox balance in primary acute myelogenous leukemia cells. Next, using proteomic, genomic, and metabolomic methods, they determined that treatment with PTL leads to induction of compensatory mechanisms that include up-regulated NADPH production via the pentose phosphate pathway as well as activation of the Nrf2-mediated oxidative stress response pathway. [J Biol Chem] Abstract | Full Article SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells The role of the SWEF proteins SWAP-70 and DEF6 in hematopoietic stem and precursor cells (HSPCs) was examined. Both SWEF proteins are expressed in HSCs. [PLoS One] Full Article Researchers investigated the effect of estrogen on hematopoietic differentiation using human pluripotent stem cells. [Cell Biosci] Full Article CLINICAL RESEARCHScientists retrospectively compared the outcome of allogeneic transplantation from matched or mismatched at a single HLA-locus unrelated donor to autologous transplantation in patients with AML in first complete remission. [J Hematol Oncol] Full Article | |
| |
REVIEWSAberrant Wnt Signaling in Leukemia The authors review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment. [Cancers] Full Article Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
| |
INDUSTRY NEWSAmgen announced that the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application for BLINCYTO® to include new data supporting the treatment of pediatric patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia. [Amgen] Press Release The Cancer Research Institute announced that it will honor biotechnology company Amgen with the 2016 Oliver R. Grace Award for Distinguished Service in Advancing Cancer Research at its September gala in New York City. [Cancer Research Institute] Press Release | |
| |
POLICY NEWSCongress Returns, with a Long Science To-Do List and Not Much Time Congress returns from a 7-week summer break with a lengthy list of unfinished business, some of great interest to the U.S. research community—and just a few weeks to tackle it. [ScienceInsider] Editorial Turkey Sacks Thousands of University Staff Turkey’s government has sacked 2,346 university staff for suspected ties to July’s attempted military coup in the country. The sackings, announced in a 1 September decree as part of a wider purge of 40,000 civil servants, are the first of an expected wave of dismissals under powers granted by state-of-emergency rules following the coup. [Nature News] Editorial
| |
EVENTSNEW 19th International Vascular Biology Meeting Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Fellow – Cancer Biology (University of Michigan) Technical Sales Representative (STEMCELL Technologies Inc.) PhD – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus) Postdoctoral Scholar – Tumor Biology (The Pennsylvania State University College of Medicine) Research Technologist (Pennsylvania State University) Postdoctoral Stipend – Development of Immune System (Lund University) Postdoctoral Research Scientist (National Taiwan University) Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute) Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania) Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center) Cytogenetics Laboratory Supervisor (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Hematopoiesis News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|