Hematopoiesis News Volume 8.43 | Oct 31 2017

TOP STORY

Transplanted Hematopoietic Stem Cells Reverse Damage Caused by Neuromuscular Disorder

Researchers report that a single infusion of wildtype hematopoietic stem and progenitor cells into a mouse model of Friedreich’s ataxia measurably halted cellular damage caused by the degenerative disease. [Press release from University of California San Diego School of Medicine discussing online prepublication in Science Translational Medicine] Press Release | Abstract

(Ranked by impact factor of the journal)

AML-Specific Cytotoxic Antibodies in Patients with Durable Graft versus Leukemia Responses

From B cells of high-risk acute myeloid leukemia (AML) patients with potent and lasting graft versus leukemia immune response responses scientists isolated monoclonal antibodies directed against antigens expressed on the cell surface of AML cells but not on normal hematopoietic and non-hematopoietic cells. [Blood] Abstract | Press Release

PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia

Human primary chronic myelogenous leukemia (CML) CD34⁺ cells and retrovirally-BCR-ABL-driven CML mouse model were employed to evaluate the effects of suppression of EZH2 by GSK126 or EZH2 specific shRNA in vitro and in vivo. [Clin Cancer Res] Abstract

Role of Thymoglobulin in Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation with Busulfan and Fludarabine Conditioning in Myeloid Malignancies

In vivo T-cell depletion using anti-thymocyte globulin is widely used in allogeneic hematopoietic stem cell transplantation (HSCT) for prophylaxis of GvHD. Scientists investigated the influence of thymoglobulin dose on GvHD following matched sibling donor HSCT with a busulfan and fludarabine preparative regimen. [Bone Marrow Transplant] Abstract

Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia

Investigators described the development and optimization of an anti-C-type lectin-like molecule-1 CAR-T-cell with potent activity on both acute myeloid leukemia (AML) cell lines and primary patient-derived AML blasts in vitro while sparing healthy hematopoietic stem cells. [Int J Mol Sci] Full Article

KDM6 and KDM4 Histone Lysine Demethylases Emerge as Molecular Therapeutic Targets in Human Acute Myeloid Leukemia

Researchers analyzed expression of histone-3-lysine demethylases and their cognate substrates in a cohort of de novo acute myeloid leukemia (AML) patients, which demonstrated that expression of H3K27Me3/2-demethylases, and selected members of H3K9Me3/2/1-demethylases, are significantly increased in AML. [Exp Hematol] Full Article

CLINICAL RESEARCH

Durable Graft-versus-Leukemia Effects without Donor Lymphocyte Infusions – Results of a Phase II Study of Sequential T-Replete Allogeneic Transplantation for High-Risk Acute Myeloid Leukemia and Myelodysplasia

Investigators performed a single-arm prospective Phase II clinical trial of sequential chemotherapy and T-replete transplantation using reduced-intensity conditioning without planned donor lymphocyte infusions. [Br J Haematol] Abstract

Homeostatic Γδ T-Cell Contents are Preserved by Granulocyte Colony-Stimulating Factor Priming and Correlate with the Early Recovery of Γδ T Subsets after Haploidentical Hematopoietic Transplantation

The authors initially compared the phenotypes of γδ T subsets including CD27^＋, CD27^－, Vδ1^＋, Vδ2^＋, Vδ1^＋CD27^＋, Vδ1^＋CD27^－, Vδ2^＋CD27^＋, and Vδ2^＋CD27^－ cells, in the peripheral blood of 20 healthy donors before and after granulocyte colony-stimulating factor mobilization. [Biol Blood Marrow Transplant] Abstract

Autologous/Allogeneic Hematopoietic Cell Transplantation (HCT) versus Tandem Autologous Transplantation for Multiple Myeloma – Comparison of Long Term Post Relapse Survival

Investigators compared post-relapse overall survival after autologous-allogenenic versus tandem autologous HCT in multiple myeloma. [Biol Blood Marrow Transplant] Abstract

Replication Stress in Hematopoietic Stem Cells in Mouse and Man

The authors present an overview of replication stress in HSCs focusing on its causes and consequences for the blood system of mice and men. [Mutat Res] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Omeros Reports Additional and Consistently Positive Data for OMS721 in Patients with Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy

Omeros Corporation announced further positive data from the company’s ongoing Phase II study of OMS721 evaluating patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. [Press release from Omeros Corporation discussing research presented at the 2017 combined annual meetings of the Center for International Blood & Marrow Transplant Research (CIBMTR) and the American Society for Blood and Marrow Transplantation (ASBMT), Salt Lake City] Press Release

FDA Grants Breakthrough Therapy Designation for BioMarin’s Valoctocogene Roxaparvovec (Formerly BMN 270), an Investigational Gene Therapy for Hemophilia A

BioMarin Pharmaceutical Inc. announced that the FDA granted valoctocogene roxaparvovec Breakthrough Therapy Designation. [BioMarin Pharmaceutical Inc.] Press Release

Novartis Submits Application to FDA for Kymriah™ (Tisagenlecleucel) in Adult Patients with r/r DLBCL, Seeking Second Indication for First-Ever FDA Approved CAR-T Therapy

Novartis announced that the company has submitted a supplemental Biologics License Application to the FDA for Kymriah™ suspension for intravenous infusion, formerly CTL019, for the treatment of adult patients with relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) who are ineligible for autologous stem cell transplant. [Novartis AG] Press Release

Six Papers by Disgraced Surgeon Should Be Retracted, Report Concludes

Sweden’s national scientific ethics board, the Expert Group on Misconduct in Research, has concluded that six papers authored by disgraced surgeon Paolo Macchiarini should be retracted. The papers describe the purported clinical success of artificial trachea “seeded” with a patient’s own stem cells. All three patients described in the papers died of complications related to the implant. [ScienceInsider] Editorial

Spanish Government Takes Control of Catalonian Universities

The Spanish government has taken over responsibility for higher education and research in Catalonia, following the region’s unilateral declaration of independence. It will retain control of spending on research centres and universities, which the League of European Research Universities says threatens institutional autonomy. [Nature News] Editorial

NEW The 2018 World Stem Cell Summit (WSCS)
January 22-26, 2018
Miami, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW PhD Studentships – Cancer Research (University of Cambridge)

Senior Customer Success Specialist – Blood & Marrow Transplantation and Cell Therapy (STEMCELL Technologies Inc.)

Staff Scientist – Normal and Malignant Hematopoiesis (University of Copenhagen)

Scientists – In Vivo Leukemia Modeling (University of Copenhagen)

Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham)

Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Hematopoietic Stem Cell Development (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique)

Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center)

Postdoctoral Positions – Stem Cell and Cancer Biology (Johns Hopkins University)

Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital, Harvard Medical School)

Postdoctoral Researcher – Cellular and Molecular Immunoregulation (International Clinical Research Center of St. Anne’s University Hospital Brno)

Postdoctoral Opportunities – Hematological Malignancies (Albert Einstein College of Medicine)

Postdoctoral Fellow – Age Associated Changes of the Hematopoietic Stem Cell Compartment (National Institutes of Health/National Institute on Aging)

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