Hematopoiesis News Volume 8.46 | Nov 21 2017

TOP STORY

Granulocyte-Derived TNFα Promotes Vascular and Hematopoietic Regeneration in the Bone Marrow

Investigators found that donor hematopoietic cells act on sinusoidal endothelial cells and induce host blood vessel and hematopoietic regeneration after bone marrow (BM) transplantation in mice. Adoptive transfer of BM, but not peripheral, granulocytes prevented the death of mice transplanted with limited numbers of HSCs and accelerated recovery of host vessels and hematopoietic cells. [Nat Med] Abstract

(Ranked by impact factor of the journal)

PD-L1 Genetic Overexpression or Pharmacological Restoration in Hematopoietic Stem and Progenitor Cells Reverses Autoimmune Diabetes

Genetically engineered or pharmacologically modulated hematopoietic stem and progenitor cells overexpressing programmed death ligand 1 (PD-L1) inhibited the autoimmune response in vitro, reverted diabetes in newly hyperglycemic nonobese diabetic (NOD) mice in vivo, and homed to the pancreas of hyperglycemic NOD mice. [Sci Transl Med] Abstract

Physiological Srsf2 P95H Expression Causes Impaired Hematopoietic Stem Cell Functions and Aberrant RNA Splicing in Mice

Researchers investigated the consequence of mutant Srsf2 expression using newly generated Vav1-Cre-mediated conditional knock-in mice. Mice carrying a heterozygous Srsf2 P95H mutation showed significantly reduced numbers of hematopoietic stem and progenitor cells and differentiation defects both in the steady-state condition and transplant settings. [Blood] Abstract

Age-Related Inflammatory Bone Marrow Microenvironment Induces Ineffective Erythropoiesis Mimicking del(5q) MDS

Scientists revealed that pathologic levels of TNFα and IL-6 inhibit erythroid colony formation and differentially affect terminal erythropoiesis through reactive oxygen species-induced caspase-3 activation and apoptosis. [Leukemia] Abstract

Single Cell Resolution of Human Hemato-Endothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium

Researchers performed single cell RNA-seq using 55 hemogenic endothelial cells, 47 vascular endothelial cells without hematopoietic potential, and 35 hematopoietic progenitor cells derived from human embryonic stem cells. [Stem Cells] Abstract

Ectopic FOXP3 Expression Preserves Primitive Features of Human Hematopoietic Stem Cells while Impairing Functional T Cell Differentiation

FOXP3-expressing HSCs showed reduced proliferation ability and increased maintenance of primitive markers in vitro in both liquid and OP9-ΔL1 co-cultures. When transplanted into immunodeficient mice, FOXP3-expressing HSCs showed significantly enhanced engraftment ability. [Sci Rep] Full Article

CLINICAL RESEARCH

A Phase II, Multicenter, Single-Arm Study to Evaluate the Safety and Efficacy of Deferasirox after Hematopoietic Stem Cell Transplantation in Children with Β-Thalassemia Major

The authors conducted a prospective, Phase II, multicenter, single-arm study to evaluate the efficacy and safety of deferasirox in patients with β-thalassemia major who have undergone hematopoietic stem cell transplantation and had evidence of iron overload. [Biol Blood Marrow Transplant] Abstract

Liver Fibrosis Alleviation after Co-Transplantation of Hematopoietic Stem Cells with Mesenchymal Stem Cells in Patients with Thalassemia Major

Researchers determined the replacement rate of damaged hepatocytes by donor-derived cells in sex-mismatched recipient patients with thalassemia major and to determine whether co-transplantation of mesenchymal stem cells and hematopoietic stem cells can alleviate liver fibrosis. [Ann Hematol] Abstract

Thrombotic Microangiopathy with Concomitant GI aGVHD after Allogeneic Hematopoietic Stem Cell Transplantation: Risk Factors and Outcome

Scientists explored the possible risk factors for the occurrence and mortality of TMA with concomitant aGVHD and to investigate outcomes and treatments of this disorder after allo-HSCT. [Eur J Haematol] Abstract

Aging of Hematopoietic Stem Cells

Scientists review the current understanding of the molecular mechanisms that contribute to HSC aging. They argue that most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on which aspects of the aging process may be reversible. [Blood] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Genentech’s HEMLIBRA (Emicizumab-kxwh) Significantly Reduced Bleeds in Phase III Study in Hemophilia A

Genentech announced positive results from the Phase III HAVEN 3 study evaluating HEMLIBRA^® in adults and adolescents with hemophilia A without inhibitors to factor VIII. [Genentech, Inc.] Press Release

FDA Approves New Treatment to Prevent Bleeding in Certain Patients with Hemophilia A

The FDA approved Hemlibra to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients with hemophilia A who have developed antibodies called factor VIII inhibitors. [The U.S. Food and Drug Administration] Press Release

LLS Funds $46 Million in New Research to Find Cures

The Leukemia & Lymphoma Society^® (LLS) committed an additional $46 million to fund the most innovative science at leading medical institutions around the world, including Memorial Sloan Kettering Cancer Center in New York, Dana-Farber Cancer Institute in Boston, City of Hope in Duarte, California, and the Walter & Eliza Hall Institute of Medical Research in Australia. [The Leukemia & Lymphoma Society^®] Press Release

Director of HHS Scientific Fraud Office Is out after Stormy 2-Year Tenure

The controversial director of the office that polices research fraud in U.S.-funded biomedical labs is temporarily moving to another agency. Kathy Partin has been removed after nearly two years as director of the U.S. Office of Research Integrity in Rockville, Maryland, according to Retraction Watch. [ScienceInsider] Editorial

European Medicines Agency Will Move to Amsterdam

The European Medicines Agency, charged with evaluating human and animal medicinal products for the European Union, will relocate to Amsterdam after it was selected in a draw of lots between it and Milan. [ScienceInsider] Editorial

Hungary Rewards Highly Cited Scientists with Bonus Grants

Some top researchers prosper in Hungary as country tries to improve its international standing in science. [Nature News] Editorial

NEW SYStem – Symposium for the Next Generation of Stem Cell Researchers
February 22-24, 2018
Vienna, Austria

NEW Standardization of the Hematopoietic Progenitor Assay Training Course
March 7-8, 2018
Vancouver, British Columbia, Canada

NEW Applications of the Hematopoietic Progenitor Assay Training Course
March 7-9, 2018
Vancouver, British Columbia, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Experimental Clinical Genetics (Lund University)

Senior Customer Success Specialist – Blood & Marrow Transplantation and Cell Therapy (STEMCELL Technologies Inc.)

Postdoctoral Positions – Immunology & Ion Channels, STAT Proteins in Hematopoietic Malignancies, and Hematopoietic/Leukemic Stem Cell Biology (New York University School of Medicine)

Postdoctoral Scientist – Molecular Genetics of Human T Cell Development (Ghent University)

PhD Position – 3D Models of the Stem Cell Niche (Karlsruhe Institute of Technology)

PhD Studentships – Cancer Research (University of Cambridge)

Staff Scientist – Normal and Malignant Hematopoiesis (University of Copenhagen)

Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham)

Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Hematopoietic Stem Cell Development (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique)

Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Age Associated Changes of the Hematopoietic Stem Cell Compartment (National Institutes of Health/National Institute on Aging)

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