Hematopoiesis News Volume 9.02 | Jan 16 2018

TOP STORY

Re-Programming Innate Immune Cells to Fight Tuberculosis

Canadian researchers’ innovative work promises to make vaccines more effective against tuberculosis and other infectious diseases like the flu. [Press release from McGill University discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Researchers hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells. Administration of β-glucan to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor, and with adaptations in glucose metabolism and cholesterol biosynthesis. [Cell] Full Article | Graphical Abstract | Press Release

Eosinophil-Derived CCL-6 Impairs Hematopoietic Stem Cell Homeostasis

Investigators demonstrated that eosinophils disrupt HSC homeostasis by impairing HSC quiescence and reconstitution ability in wild-type mice following ovalbumin challenge and even by causing bone marrow HSC failure and exhaustion in Cd3δ-Il-5 transgenic mice. [Cell Res] Full Article

Escape from Thymic Deletion and Anti-Leukemic Effects of T Cells Specific for Hematopoietic Cell-Restricted Antigen

The authors showed that T cells specific for hematopoietic cell-restricted antigens are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. H60-specific thymic deletion escapee CD8⁺ T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched bone marrow transplantation, regressing H60⁺ hematological tumors. [Nat Commun] Full Article

CAR-T Cells Targeting CLL-1 as an Approach to Treat Acute Myeloid Leukemia

Researchers tested the expression of C-type lectin-like molecule-1 (CLL-1) antigen on peripheral blood cells and bone marrow cells in healthy donor and acute myeloid leukemia (AML) patients. The CLL-1 chimeric antigen receptor (CAR)-T cells specifically lysed CLL-1⁺ cell lines as well as primary AML patient samples in vitro. Strong anti-leukemic activity was observed in vivo by using a xenograft model of disseminated AML. [J Hematol Oncol] Full Article

AIF Loss Deregulates Hematopoiesis and Reveals Different Adaptive Metabolic Responses in Bone Marrow Cells and Thymocytes

The authors analyzed the consequences of the mitochondrial oxidative phosphorylation/metabolism disorder associated with the cell-specific hematopoietic ablation of apoptosis-inducing factor (AIF). [Cell Death Differ] Abstract

Megakaryocyte-Derived Excessive TGFβ1 Inhibits Proliferation of Normal Hematopoietic Stem Cells in Acute Myeloid Leukemia

Scientists demonstrated that TGFβ signaling was up-regulated in HSCs from MLL-AF9 induced acute myeloid leukemia mice bone marrow, due to excessive production of TGFβ1 especially from megakaryocytes, and over-activation of latent TGFβ1 protein. They also found that SMAD3, a signal transducer of TGFβ1, directly bound to Egr3 and up-regulated its expression to cause proliferation arrest of HSCs. [Exp Hematol] Full Article

Phenotypic and Molecular Characterization of a Serum-Free Miniature Erythroid Differentiation System Suitable for High Throughput Screening and Single Cell Assays

Investigators describe a serum-free erythroid differentiation system suitable for small-scale and single cell experiments. This system generates large numbers of terminally differentiated erythroid cells of very high purity. [Exp Hematol] Abstract

CLINICAL RESEARCH

Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation

Researchers investigated the impact of sensitization on and the efficacy of a desensitization protocol utilizing syngeneic hematopoietic stem cell transplantation to prevent antibody-mediated rejection in vascularized composite allotransplantation. [Transplantation] Abstract

Immune Checkpoint Molecules in Acute Myeloid Leukemia: Managing the Double-Edged Sword

The authors address the involvement of co-inhibitory signaling in acute myeloid leukemia (AML) immune evasion and discuss the opportunities for checkpoint blockers in AML treatment. [Br J Haematol] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

ProtoKinetix Has Entered into a Research Agreement with The University of British Columbia to Test the Effect of its AAGP^™ on Monoclonal Antibody Production and Bone Marrow Recovery

ProtoKinetix, Incorporated announced that it has entered into a research agreement with The University of British Columbia, under the direction of principal investigator Dr. Kelly McNagny, Professor, Faculty of Medicine, Department of Medical Genetics. This research agreement is to test and determine the effect of AAGP^™ on monoclonal antibody production and bone marrow recovery. [ProtoKinetix Inc.] Press Release

Forty Seven Inc. to Collaborate on a Novel Immuno-Oncology Combination for Leukemia and Bladder Cancer

Forty Seven Inc. announced an agreement with Genentech Inc. for Genentech to sponsor two clinical trials combining Forty Seven’s CD47 antibody, Hu5F9-G4, with Genentech’s PD-L1 antibody, atezolizumab, in patients with acute myeloid leukemia and with urothelial cancer. [Forty Seven Inc.] Press Release

Helsinn Group and MEI Pharma Announce that Pracinostat has Received Orphan Drug Designation from the European Medicines Agency for the Treatment of Acute Myeloid Leukemia (AML)

Helsinn and MEI Pharma, Inc. announced that the European Medicines Agency has granted Orphan Drug Designation to pracinostat, an investigational drug candidate currently in a Phase III study in combination with azacitidine for the treatment of AML in adult patients unfit to induction chemotherapy. [MEI Pharma, Inc.] Press Release

South Korean Universities Reach Agreement with Elsevier after Long Standoff

After a months-long standoff, a consortium of hundreds of South Korean universities has reached a new deal with scientific publisher Elsevier for access to ScienceDirect, a database containing content from 3,500 academic journals and thousands of electronic books. [ScienceInsider] Editorial

Rising Star Appointed UK Science Minister

The United Kingdom has gained a new science minister as part of a broader reshuffle of government posts. Sam Gyimah, who moves from the Ministry of Justice, was appointed minister for universities and science, replacing Jo Johnson. [Nature News] Editorial

NEW Gordon Research Conferences: Chemotactic Cytokines
June 3-8, 2018
Newry, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Hematopoiesis (University of Liege)

NEW Scientific Officer – Myeloma and Leukemia (Institute of Cancer Research)

Postdoctoral Associate – Experimental Hematology & Cancer Biology (University of Florida Health Cancer Center)

Postdoctoral Scholarship – Hematology and Transfusion Medicine (Lund University)

Postdoctoral Position – Hematology and Cancer Biology (University of Florida)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Colorado/Anschutz Medical Campus)

Investigator – Stem Cell Research (BloodCenter of Wisconsin)

Research Data Analyst – Hematology (National Institutes of Health)

Postdoctoral Fellow – Suppression of Fetal Hemoglobin in Adult Red Cells (Boston Children’s Hospital)

Postdoctoral Scholarship – Hematology and Transfusion Medicine (Lund University)

Staff Clinician – Hematology (National Heart, Blood and Lung Institute)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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