Hematopoiesis News 9.14 April 10, 2018 | |
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TOP STORYStem Cell Discovery Could Improve Bone Marrow Transplantation New findings about hematopoietic stem cells—which give rise to all blood cells—could lead to improvements in bone marrow transplantation, say scientists. [Press release from Columbia University discussing online prepublication in Science] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells Investigators showed that a pseudouridylation-driven posttranscriptional program steers translation control to impact stem cell commitment during early embryogenesis. Dysregulation of this posttranscriptional regulatory circuitry impaired hematopoietic stem cell commitment and was common to aggressive subtypes of human myelodysplastic syndromes. [Cell] Abstract | Press Release | Graphical Abstract Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment The authors determined the age-related functional changes to the HSC compartment using over 400 single-cell transplantation assays. Notably, myeloid-restricted repopulating progenitors frequency increased dramatically with age, while multipotent HSCs expanded modestly within the bone marrow. [Cell Stem Cell] Full Article | Graphical Abstract To characterize transcriptional and post-transcriptional changes in HSCs during development, investigators leveraged high-throughput genomic approaches to profile miRNAs, lincRNAs, and mRNAs. Their findings indicate that HSCs manifest distinct alternative splicing patterns in key hematopoietic regulators. [Cell Stem Cell] Abstract | Graphical Abstract Investigators showed that red blood cells (RBCs) contain membrane skeleton-associated nonmuscle myosin II (NMIIA) puncta, identified as bipolar filaments by superresolution fluorescence microscopy. Blebbistatin-treated RBCs exhibited elongated shapes, loss of membrane curvature, and enhanced deformability, indicating a role for NMIIA contractility in promoting membrane stiffness and maintaining RBC biconcave disk cell shape. [Proc Natl Acad Sci USA] Abstract | Press Release The authors report that JMJD1B, previously identified as a lysine demethylase for H3K9me2, mediates arginine demethylation of H4R3me2s and its intermediate, H4R3me1. Knockout of JMJD1B blocked demethylation of H4R3me2s and/or H3K9me2 at distinct clusters of genes and impairs the activation of genes important for hematopoietic stem/progenitor cell differentiation and development. [Cell Rep] Full Article | Press Release | Graphical Abstract Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo Researchers showed that Dnmt3a-null HSCs can regenerate over at least 12 transplant generations in mice, far exceeding the lifespan of normal HSCs. Molecular characterization revealed that this in vivo immortalization is associated with gradual and focal losses of DNA methylation at key regulatory regions associated with self-renewal genes, producing a highly stereotypical HSC phenotype in which epigenetic features are further buttressed. [Cell Rep] Full Article | Graphical Abstract NFκB Regulates p21 Expression and Controls DNA Damage-Induced Leukemic Differentiation Scientists showed that the NFκB pathway directly activates expression of the proliferation inhibitor p21 in response to DNA damage in myeloid leukemia cells. [Oncogene] Abstract PLAG1 and USF2 Co-Regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells Coincident overexpression of USF2 and PLAG1 in primitive cord blood cells enhanced Musashi-2 (MSI2) transcription and yielded cellular phenotypes, including expansion of CD34+ cells in vitro, consistent with that achieved by direct MSI2 overexpression. Global chromatin immunoprecipitation sequencing analyses confirmed a preferential co-binding of PLAG1 and USF2 at the promoter of MSI2, as well as regulatory regions corresponding to genes with roles in hematopoietic stem and progenitor cell homeostasis. [Stem Cell Reports] Full Article CLINICAL RESEARCHResearchers investigated the predictive value of both stored and biologically active iron on post-transplantation outcomes in patients with acute myeloid leukemia or myelodysplastic syndrome undergoing allogenic hemopoietic cell transplantation. [Lancet Haematol] Abstract | |
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REVIEWSThe Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies The authors cover the current understanding of the role of inflammation in the initiation, progression, and complications of myeloid hematologic malignancies, drawing from clinical studies as well as murine models. [Cancers (Basel)] Full Article Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSDaiichi Sankyo Company, Limited and DarwinHealth announced they have entered into a research agreement providing Daiichi Sankyo with exclusive access to DarwinHealth’s proprietary novel cancer target database in order to identify potential new targets for cancer drug development. [Daiichi Sankyo Company, Limited] Press Release Bio-Path Holdings, Inc. announced that interim data from its Phase II study of prexigebersen in combination with low-dose cytarabine for the treatment of AML has demonstrated that the combination therapy continues to be well-tolerated and has shown early anti-leukemic activity in nearly 50% of evaluable AML patients including four patients with complete remission and four with stable disease to date in this study. [Bio-Path Holdings, Inc.] Press Release Bioniz Therapeutics Initiates Phase I/II Clinical Study of BNZ-1 in T-Cell Leukemia and Lymphoma Bioniz Therapeutics, Inc. announced that it has initiated a Phase I/II open-label clinical study of its lead product candidate BNZ-1 in patients with large granular lymphocyte leukemia or refractory cutaneous T-cell lymphoma. [Bioniz Therapeutics, Inc. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSWeb of Science Owner Buys Tool that Offers One-Click Access to Journal Articles The owner of the large scholarly search engine Web of Science — Clarivate Analytics — has bought a start-up company whose tool gives researchers one-click, legal access to journal articles even when off campus. [Nature News] Editorial India Creates Unique Tiered System to Punish Plagiarism The Indian government has adopted its first regulations on academic plagiarism—rules that some researchers say are too lenient and others fear go too far and will be difficult to implement. [ScienceInsider] Editorial Got Data? Survey of 2017 March for Science Doesn’t Make the Grade A group of researchers has released the first results of a large survey of those who participated in and supported last year’s March for Science. Some social scientists say the analysis is fundamentally flawed and reflects poorly on an organization that champions scientific rigor. [ScienceInsider] Editorial Science’s Vast Gender Pay Gap Revealed in UK Wage Data Many UK science employers pay women much less than men, and some institutions are far less equal than others, according to an analysis conducted by Nature of statistics released. [Nature News] Editorial
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EVENTSNEW 6th Annual German Stem Cell Network (GSCN) Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet) NEW Postdoctoral Researchers – Plasticity of Myeloid Cells (BioMed X Innovation Center) NEW Research Group Leader – Plasticity of Myeloid Cells (BioMed X Innovation Center) Postdoctoral Associate – Leukemia (St. Jude Children’s Research Hospital) Tenure Track Faculty Position – Hematopathology (University of Virginia) Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University) Postdoctoral Fellow – Hematopoiesis and Hematopoietic Stem Cell Biology (City of Hope) Postdoctoral Position – Tregs in the Hematopoietic Stem Cell Niche (Columbia University) Postdoctoral Associate – Stem Cell Biology and Cancer Epigenetics (The Jackson Laboratory) Postdoctoral Fellow – Stem Cells, Development & Cancer (Albert Einstein College of Medicine) Postdoctoral Research Fellow – Hematopoiesis (Fred Hutchinson Cancer Research Center) Postdoctoral Positions – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center) Postdoctoral Associate – Stem Cell Biology (Duke University) Postdoctoral Research Associate – Mechanisms of Leukemia (University of Virginia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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