Hematopoiesis News 9.17 May 1, 2018 | |
| |
TOP STORYStudy Reveals Vital Physiological Role of Cell Death and Inflammation Scientists have made a seminal discovery of a fundamental biological process that governs cell death and inflammation during the normal development of an embryo, which is also crucial for the development of virtually all cellular components of the blood system. [Press release from the University College London discussing online prepublication in Nature] Press Release | Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Scientists collected single-cell chromatin accessibility profiles across ten populations of immunophenotypically defined human hematopoietic cell types and constructed a chromatin accessibility landscape of human hematopoiesis to characterize differentiation trajectories. [Cell] Abstract | Graphical Abstract Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress Investigators showed that Spred1, a negative regulator of RAS-MAPK signaling, safeguards HSC homeostasis in animals fed a high-fat diet. Under steady-state conditions, Spred1 negatively regulated HSC self-renewal and fitness, in part through Rho kinase activity. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract A mitochondrial-targeted 2C-type Ser/Thr protein phosphatase (PPM1K) deficiency led to a notable decrease in MEIS1/p21 signaling to reduce the glycolysis and quiescence of hematopoietic stem cells, followed by a severe impairment in repopulation activities. [Cell Rep] Full Article | Graphical Abstract Researchers showed that UL7 is a ligand for Fms-like tyrosine kinase 3 receptor (Flt-3R), a well-known critical factor in hematopoietic progenitor cell differentiation. [MBio] Full Article Scientists identified staurosporine, a serine/threonine kinase inhibitor, as a small molecule that could be added to the transduction process to increase the proportion of genetically modified hematopoietic stem and progenitor cells by overcoming a lentiviral vector entry barrier. [Mol Ther Methods Clin Dev] Full Article c-MYC and Reactive Oxygen Species Play Roles in Tetrandrine-Induced Leukemia Differentiation Investigators showed that tetrandrine effectively induced differentiation and autophagy in leukemia cells. Tetrandrine treatment activated the accumulation of reactive oxygen species and inhibited c-MYC protein expression. [Cell Death Dis] Full Article miR-9 Upregulation Leads to Inhibition of Erythropoiesis by Repressing FoxO3 miR-9 suppressed expression of the erythroid transcriptional regulator FoxO3, and its down-stream targets Btg1 and Cited 2 in erythroid progenitor cells, while expression of a constitutively active form of FoxO3 reversed miR-9-induced suppression of erythroid differentiation, and inhibited miR-9-induced reactive oxygen species production. [Sci Rep] Full Article Hematopoietic Insults Damage Bone Marrow Niche by Activating p53 in Vascular Endothelial Cells Researchers demonstrated that p53 becomes activated in BM endothelial cells upon hematopoietic stresses such as irradiation and chemotherapeutic treatments. [Exp Hematol] Abstract Scientists report that HSCs are highly sensitive to the balance of branched-chain amino acids (BCAAs), with both proliferation and survival reduced by BCAA imbalance. [Exp Hematol] Abstract Mtf2-PRC2 Control of Canonical Wnt Signaling Is Required for Definitive Erythropoiesis Gene regulatory network analysis demonstrated Mtf2 directly regulates Wnt signaling in erythroblasts, leading to activated canonical Wnt signaling in Mtf2-deficient erythroblasts, while chemical inhibition of canonical Wnt signaling rescued Mtf2-deficient erythroblast differentiation in vitro. [Cell Discov] Full Article CLINICAL RESEARCHResearchers performed a retrospective study to investigate progression-free and overall survival outcomes and toxicities of lenalidomide maintenance therapy compared with bortezomib maintenance in multiple myeloma patients post-autologous hematopoietic cell transplantation. [Bone Marrow Transplant] Abstract | |
| |
REVIEWSVitamin C in Stem Cell Reprogramming and Cancer Vitamin C can modulate embryonic stem cell function, enhance reprogramming of fibroblasts to induced pluripotent stem cells, and hinder the aberrant self-renewal of hematopoietic stem cells through its ability to enhance the activity of either Jumonji C domain-containing histone demethylases or ten-eleven translocation DNA hydroxylases. [Trends Cell Biol] Abstract New Insights from Studies of Clonal Hematopoiesis Clonal hematopoiesis describes an asymptomatic expansion of blood cells descended from a single hematopoietic stem cell. The authors discuss the epidemiology, molecular mechanisms, and clinical consequences of this common and clinically important biological state. [Clin Cancer Res] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
| |
SCIENCE NEWSSancilio Pharmaceuticals Company to Present New Research on Altemia™ to Treat Sickle Cell Disease Sancilio Pharmaceuticals Company, Inc will present new research data from the Phase II study on SC411. [Press release from Sancilio Pharmaceuticals Company, Inc discussing research to be presented at the 2108 American Society Pediatric Hematology and Oncology (ASPHO) Meeting, Pittsburgh] Press Release | |
| |
INDUSTRY NEWSSTEMCELL Technologies Announces $45 Million Government Funding for Advanced Manufacturing Facility STEMCELL Technologies announced a $45 million joint funding agreement between the Governments of Canada and British Columbia to help the company build a state-of-the-art advanced manufacturing facility. The funding agreement will accelerate the Vancouver company’s rapidly scaling business of providing cutting-edge reagents and tools to support life science researchers around the world working in the cell therapy and regenerative medicine fields. [STEMCELL Technologies Inc.] Press Release An innovative therapy that uses a patient’s own immune system to attack cancer stem cells is one of three new clinical trials approved for funding by the Board of the California Institute for Regenerative Medicine, the state’s Stem Cell Agency. [California Institute for Regenerative Medicine] Press Release Omeros Corporation announced that the FDA has granted breakthrough therapy designation to OMS721 for the treatment of patients with high-risk hematopoietic stem cell transplant-associated thrombotic microangiopathy (TMA), specifically those patients who have persistent TMA despite modification of immunosuppressive therapy. [Omeros Corporation] Press Release Lin BioScience announced that the FDA has granted Orphan Drug Designation to LBS-007 for acute lymphoblastic leukemia. [Lin BioScience] Press Release | |
| |
POLICY NEWSFederal Appeals Court Hears CRISPR Patent Dispute A federal appeals court heard arguments that the U.S. patent office made legal mistakes when reviewing its ruling on CRISPR, the genome editor. [ScienceInsider] Editorial Harassment and Discrimination Allegations Roil a Top US Biomedical Institute Allegations of sexual harassment and assault levelled against Inder Verma, a prominent cancer biologist at the Salk Institute for Biological Studies in La Jolla, California, cap a tumultuous ten months for the well-known research centre. [Nature News] Editorial Science in North Korea: How Easing the Nuclear Stand-Off Might Bolster Research The isolated nation publishes fewer than 100 scholarly articles a year — but as political tensions thaw, researchers hope for greater collaboration. [Nature News] Editorial Disgraced Surgeon Is Still Publishing on Stem Cell Therapies Paolo Macchiarini, an Italian surgeon, has been fired from two institutions and faces the retraction of many of his papers after findings of scientific misconduct and ethical lapses in his research—yet this hasn’t prevented him from publishing again in a peer-reviewed journal. [ScienceInsider] Editorial
| |
EVENTSNEW 10th International Heinrich F. C. Behr-Symposium on Stem Cells and Cancer NEW 6th Cambridge International Stem Cell Symposium Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Position – Leukemia Research (Oslo Universitetssykehus HF) Postdoctoral Fellow – B-Cell Lymphoma (University of Texas Health Science Center at San Antonio) Postdoctoral Position – Stem Cell and Cancer Research (Institute for Research in Biomedicine) Postdoctoral Position – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet) Postdoctoral Researchers – Plasticity of Myeloid Cells (BioMed X Innovation Center) Postdoctoral Associate – Leukemia (St. Jude Children’s Research Hospital) Tenure Track Faculty Position – Hematopathology (University of Virginia) Postdoctoral Fellow – Hematopoiesis and Hematopoietic Stem Cell Biology (City of Hope) Postdoctoral Associate – Stem Cell Biology and Cancer Epigenetics (The Jackson Laboratory) Postdoctoral Fellow – Stem Cells, Development & Cancer (Albert Einstein College of Medicine) Postdoctoral Research Associate – Mechanisms of Leukemia (University of Virginia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Hematopoiesis News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|