Hematopoiesis News 9.25 June 26, 2018 | |
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TOP STORYInvestigators showed that mice lacking miR-143/145 have impaired hematopoietic stem/progenitor cell activity with depletion of functional hematopoietic stem cells, but activation of progenitor cells. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that histone 3 lysine 4 (H3K4) methyltransferases play essential roles in the hematopoietic system by showing that conditional mutagenesis of Setd1b in adult mice provoked aberrant homeostasis of hematopoietic stem and progenitor cells. [eLife] Full Article The authors showed that iron overload impairs the frequency and colony-forming capacity of normal hematopoietic stem and progenitor cells, especially in erythroid, in myelodysplastic syndrome mice, which at least in part, due to growth differentiation factor 11 induced reactive oxygen species and shortening survival of myelodysplastic syndrome mice. [Haematologica] Abstract | Full Article TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells To examine the effect of transforming growth factor β1 (TGF-β1) on the hematopoietic stem cell (HSC) function, the authors used an in vitro culture system in which single HSCs divide with the retention of their short- and long-term reconstitution ability. [Stem Cell Reports] Full Article | Graphical Abstract Investigators report that intercellular adhesion molecule-1 (ICAM-1) maintains HSC quiescence and repopulation capacity in the niche. [Stem Cell Reports] Full Article | Graphical Abstract Researchers analyzed the contribution of multiple signaling molecules in proliferation of hematopoietic stem cells. [ACS Synth Biol] Abstract | Graphical Abstract The purpose of this study was to compare the circulating progenitor cell response, particularly the inflammatory-primed haematopoietic stem and progenitor subpopulation, to a six week endurance exercise training intervention between lean and obese adults. [J Physiol] Abstract | Press Release Scientists investigated whether mesenchymal stem cells (MSCs) could contribute to the expansion of hematopoietic cells and mitigate radiation-induced hematopoietic injury in vitro and in vivo. They found that co-culture with MSCs promoted hematopoietic progenitor/stem cell maintenance by providing a bone marrow-like microenvironment. [Sci Rep] Full Article Researchers report binding maps for additional transcription factors by using chromatin immunoprecipitation-sequencing, to address the underlying mechanisms regulating self-renewal properties of lineage-CD34+ subpopulation. [Integr Biol (Camb)] Abstract CLINICAL RESEARCHInvestigators determined whether ROS levels in donor HSCs correlate with neutrophil and platelet engraftment in patients following bone marrow transplantation. [Biol Blood Marrow Transplant] Abstract To investigate the prognosis of patients with adult B-cell acute lymphoblastic leukemia (B-ALL) with Ikaros family zinc-finger 1 (IKZF1) mutation and determine the role of allogeneic hematopoietic stem cell transplantation in improving the clinical outcome, researchers detected the IKZF1 mutation and BCR-ABL fusion gene at diagnosis in the bone marrow of 164 adult patients with B-ALL, and analyzed the clinical data of these patients retrospectively. [Bone Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSThe authors summarize the current knowledge on how alterations in dietary and metabolic factors could alter the risk of leukemia development following ionizing radiation exposure by inhibiting or even reversing the leukemic progression. [Int J Radiat Biol] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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SCIENCE NEWSBioLineRx Presents New Overall Survival Data from Phase IIa Study for BL-8040 in r/r AML Patients BioLineRx Ltd. announced that new data showed that BL-8040, combined with high dose cytarabine, significantly enhanced overall survival in difficult-to-treat relapsed or refractory AML (r/r AML) patients in a Phase IIa clinical trial. [Press release from BioLineRx Ltd. discussing research presented at the 23rd Annual Congress of the European Hematology Association (EHA), Stockholm] Press Release | |
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INDUSTRY NEWSMoleculin Receives Approval for Leukemia Clinical Trial Moleculin Biotech, Inc. announced it has received Polish National Office approval to begin its second Phase I/II clinical trial to study Annamycin for the treatment of relapsed or refractory acute myeloid leukemia. [Moleculin Biotech, Inc.] Press Release Amgen announced that the European Commission has granted a full marketing authorization for BLINCYTO® based on the overall survival data from the Phase III TOWER study in adult patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia. [Amgen Inc.] Press Release Kalytera Provides Update on Its Lead Program in Prevention and Treatment of GvHD Kalytera Therapeutics, Inc. provided an update on its lead clinical development program evaluating cannabidiol for the prevention and treatment of acute graft versus host disease. [Kalytera Therapeutics, Inc.] Press Release | |
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POLICY NEWSThe European country’s autocratic government has made a disturbing grab at the nation’s scientific institutions. [Nature News] Editorial Senate Panel Proposes $2 Billion, 5.4% Increase for NIH A U.S. Senate appropriations subcommittee approved a spending bill that calls for giving the National Institutes of Health (NIH) a $2 billion, 5.4% increase to $39.1 billion in the 2019 fiscal year that begins 1 October. [ScienceInsider] Editorial New Group Aims to Bolster Science in Policymaking Symbolically, it’s pushing back against the Trump administration’s efforts to cut research funding. Practically, it’s providing grant money to academic researchers in a wide variety of scientific fields, including biomedical, life, engineering, physical, law and public policy. [Scientific American] Editorial White House Proposes a Narrowing of FDA’s Mission — And a New Name The Trump administration has proposed a fundamental change to the mission of the FDA, one that would transfer most of the responsibility for regulating food safety to the Department of Agriculture and rename the FDA the “Federal Drug Administration”. [STAT News] Editorial US-Chinese Trade War Puts Scientists in the Cross Hairs Scientific research in the United States could become collateral damage in the country’s escalating trade dispute with China. Both countries went head-to-head in mid-June over tariffs on a long list of goods that includes lab equipment and reagents. That is likely to increase the cost of scientific research, and the impact could be felt more keenly in US labs. [Nature News] Editorial African Scientists Launch Their Own Preprint A group of open science advocates have launched the first preprint aimed exclusively at African scientists. AfricArxiv seeks to improve the visibility of African science by helping academics share their work quickly, say co-founders Justin Ahinon, and Jo Havemann. [Nature News] Editorial
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EVENTSNEW American Society of Hematology (ASH) Meeting on Lymphoma Biology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Stem Cell Biology & Engineering (New York Blood Center) Research Technologist – Hematopoietic (STEMCELL Technologies Inc.) Research Fellow – Epigenetics and Hematology (University of Edinburgh) Postdoctoral Fellow – Leukemogenesis (Erasmus Medical Center Cancer Institute) Postdoctoral Scientist – Stem Cell Biology (University of Oxford) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Cancer Researchers – Hematologic Malignancy (Cedars-Sinai Medical Center) Postdoctoral Position – Stem Cell and Cancer Research (Institute for Research in Biomedicine) Postdoctoral Research Associate – Mechanisms of Leukemia (University of Virginia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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