Hematopoiesis News Volume 9.26 | Jul 3 2018

TOP STORY

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

The authors showed that Id1 was induced in HSCs by cytokines that promote HSC proliferation and differentiation, suggesting that it functions in stress hematopoiesis. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Single-Cell Transcriptomics Reveal the Dynamic of Hematopoietic Stem Cell Production in the Aorta

Researchers identified the genes and transcription factor networks activated during the endothelial-to-hematopoietic switch and intra-aortic hematopoietic clusters cell maturation toward an HSC fate. [Nat Commun] Full Article | Press Release

Coexpression Profile of Leukemic Stem Cell Markers for Combinatorial Targeted Therapy in AML

To identify target antigen combinations specific for acute myeloid leukemia (AML) and leukemic stem cells, investigators generated a detailed protein expression profile based on flow cytometry of primary AML and normal bone marrow samples, and a recently reported integrated normal tissue proteomic data set. [Leukemia] Full Article

Modeling ASXL1 Mutation Revealed Impaired Hematopoiesis Caused by Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

H2AK119ub1 level around the promoter region of p16Ink4a was significantly decreased in Asxl1^G643fs/+ HSCs, suggesting perturbation of Bmi1-driven H2AK119ub1 histone modification by mutated Asxl1. [Leukemia] Abstract

Immunomodulatory Drugs Downregulate IKZF1 Leading to Expansion of Hematopoietic Progenitors with Concomitant Block of Megakaryocytic Maturation

Scientists demonstrated that the immunomodulatory drugs induce self-renewal of hematopoietic progenitors and upregulate megakaryocytic colonies by inhibiting apoptosis and increasing proliferation of early megakaryocytic progenitors via down-regulation of IKZF1. [Haematologica] Abstract | Full Article

Global Transcriptional Response to CRISPR/Cas9-AAV6 Based Genome Editing in CD34⁺ Hematopoietic Stem and Progenitor Cells

The authors performed global microarray-based gene expression measurements on human CD34⁺ hematopoietic stem and progenitor cells that underwent editing. They probed effects of the entire editing process as well as each component individually, including electroporation, Cas9 with chemically-modified sgRNA, and AAV6 transduction. [Mol Ther] Abstract | Graphical Abstract

Efficacy and Safety of a Clinically Relevant Foamy Vector Design in Human Hematopoietic Repopulating Cells

Human CD34⁺ cord blood cells were exposed to an enhanced green fluorescent protein expressing vector, FV-EGW-A1, at a multiplicity of infection of 10 and then maintained in vitro or transplanted into immunodeficient mice. [J Gene Med] Abstract

Induction and Detection of Autophagy in Aged Hematopoietic Stem Cells by Exposing Them to Microvesicles Secreted by HSC-Supportive Mesenchymal Stromal Cells

Investigators describe the protocol for induction of autophagy in aged HSCs by incubating them with microvesicles collected from young mesenchymal stromal cells (MSCs) or rescued aged MSCs. [Methods Mol Biol] Abstract

CLINICAL RESEARCH

Allogeneic Hematopoietic Stem Cell Transplantation for Children and Adolescents with High-Risk Cytogenetic AML: Distinctly Poor Outcomes of FUS–ERG-Positive Cases

Data on 169 children and adolescents with high-risk cytogenetic abnormalities (HR-AML) who received their first allo-hematopoietic stem cell transplantation (HSCT) in first or second remission between 2000 and 2015 were extracted from a nationwide, Japanese HSCT registry. [Bone Marrow Transplant] Abstract

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Reactive Oxygen Species in Hematopoiesis: Leukemic Cells Take a Walk on the Wild Side

The authors analyze the importance of reactive oxygen species for hematopoiesis and include evidence showing that cells from leukemia patients live under oxidative stress. [J Exp Clin Cancer Res] Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

uniQure Enrolls First Patient in Phase III HOPE-B Pivotal Study of AMT-061 in Patients with Hemophilia B

uniQure N.V. announced that it has enrolled its first patient in the Phase III HOPE-B pivotal study of AMT-061, an investigational AAV5-based gene therapy incorporating the Padua variant of Factor IX variant for the treatment of patients with severe and moderately severe hemophilia B. [uniQure N.V.] Press Release

Vyxeos™ Receives Positive CHMP Opinion for Treatment of Certain Types of High-Risk Acute Myeloid Leukemia

Jazz Pharmaceuticals plc announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending marketing authorization of Vyxeos™ 44 mg/100 mg powder for concentrate for solution for infusion for the treatment of adults with newly diagnosed, therapy-related acute myeloid leukemia or acute myeloid leukemia with myelodysplasia-related changes. [Jazz Pharmaceuticals plc] Press Release

LGBTQ Scientists Are Still Left Out

People who identify as LGBTQ are leaking out of the scientific pipeline in similar ways to women and those from minority ethnic groups. But many initiatives to increase diversity do not support them. Including LGBTQ people in diversity initiatives would foster their representation, and it could bring in perspectives that improve science itself. [Nature News] Editorial

Europe’s Biggest Research Fund Cracks Down on ‘Ethics Dumping’

Ethics dumping — doing research deemed unethical in a scientist’s home country in a foreign setting with laxer ethical rules — will be rooted out in research funded by the European Union, officials announced. [Nature News] Editorial

U.S. Lawmakers Want NIH and CDC Foundations to Say More about Donors

A key congressional spending panel has fired a shot across the bow of two federally chartered medical foundations, warning that the way they disclose information about donors may not pass muster. [ScienceInsider] Editorial

NEW European Society for Medical Oncology (ESMO) 2018 Congress
October 19-23, 2018
Munich, Germany

Visit our events page to see a complete list of events in the community.

NEW Investigator Scientist – DNA Repair Pathways (Medical Research Council)

NEW Postdoctoral Research Fellows – Tissue Morphogenesis (Max-Planck-Institute for Molecular Biomedicine)

NEW Career Development Program – Glycoscience (BloodCenter of Wisconsin)

Research Technologist – Hematopoietic (STEMCELL Technologies Inc.)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Postdoctoral Researcher – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet)

Research Fellow – Epigenetics and Hematology (University of Edinburgh)

Postdoctoral Fellow – Leukemogenesis (Erasmus Medical Center Cancer Institute)

Postdoctoral Scientist – Stem Cell Biology (University of Oxford)

Postdoctoral Position – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Postdoctoral Research Associate – Mechanisms of Leukemia (University of Virginia)

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