Hematopoiesis News 9.30 July 31, 2018 | |
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TOP STORYSuppression of m6A Reader Ythdf2 Promotes Hematopoietic Stem Cell Expansion In Ythdf2 knockout hematopoietic stem and progenitor cells and YTHDF2 knockdown human umbilical cord blood HSCs, these mRNAs were stabilized, facilitating HSC expansion. Knocking down one of YTHDF2′s key targets, Tal1 mRNA, partially rescued the phenotype. [Cell Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Genomic profiling of three early-onset acute myeloid leukemias (AML) identified germline loss of MBD4 as an initiator of 5mC-dependent hypermutation. Sequential sampling of germline cases demonstrated repeated expansion of blood cell progenitors with pathogenic mutations in DNMT3A, a key driver gene for both clonal hematopoiesis and AML. [Blood] Abstract Conditioned media from pitpα-/- and pitpα-/-/β-/- megakaryocytes significantly suppressed hematopoietic progenitor cell (HPC) colony formation which was completely extinguished in vitro by neutralizing anti-TGF-β antibody, and treatment of pitpα-/-/β-/- mice in vivo with anti-TGF-β antibodies completely reverted their defects in bone marrow HSC and HPC numbers. [Blood] Abstract Researchers found an association between reduced miR-150 levels in chronic myeloid leukemia blast cells and their resistance to tyrosine kinase inhibitors. Although tyrosine kinase inhibitors successfully disrupted BCR-ABL1 kinase activity in proliferating chronic myeloid leukemia cells, this treatment inefficiently targeted quiescent leukemic stem cells. [Haematologica] Abstract Hematopoietic cells undergoing granulocytic differentiation exhibited increased miR-143 expression. Overexpression or ablation of miR-143 expression resulted in accelerated granulocytic differentiation or block of differentiation, respectively. [Cell Death Dis] Full Article The Histone Chaperone NAP1L3 Is Required for Hematopoietic Stem Cell Maintenance and Differentiation With shRNA or CRISPR-Cas9 mediated loss of function of mouse Nap1l3 and with overexpression of the gene, the number of colony-forming cells and myeloid progenitor cells in vitro were reduced. Downregulation of human NAP1L3 in umbilical cord blood HSCs impaired the maintenance and proliferation of HSCs both in vitro and in vivo. [Sci Rep] Full Article Hematopoietic stem/progenitor cells obtained from the differentiation system formed robust erythroid, granulocyte and monocyte/macrophage colonies in CFU assay, and could be induced to generate functional macrophages with robust phagocytic ability. [Stem Cell Res Ther] Full Article CLINICAL RESEARCHResearchers identified three factors on multivariate analysis as significantly associated with an increased risk for donor cell leukemia: use of growth factors within the first 100 days after transplantation, in vivo T-cell depletion and multiple allografts. [Leukemia] Abstract Scientists determined retrospectively, through a single-center evaluation, whether FDG PET-CT normalized semi-quantitative parameters could predict response to induction chemotherapy and hematopoietic stem cell transplantation, as well as disease progression and progression-free survival in multiple myeloma patients, thus becoming a tool of personalized medicine. [Eur J Nucl Med Mol Imaging] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSAplastic Anemia: Etiology, Molecular Pathogenesis and Emerging Concepts The emergence of newer genomic sequencing and other techniques is incrementally improving the understanding of the pathogenic mechanisms of aplastic anemia (AA), the detection of the disease, and ultimately offers the potential to improve patient outcomes. The authors discuss the current understanding of the immunobiology, molecular pathogenesis, and future directions of such for AA. [Eur J Haematol] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSBluebird Bio, Inc. announced that its investigational LentiGlobin™ gene therapy for the treatment of adolescent and adult patients with transfusion-dependent β-thalassemia and a non-β0/β0 genotype, was granted an accelerated assessment by the Committee for Medicinal Products for Human Use of the European Medicines Agency, for its upcoming marketing authorization application. [Bluebird Bio, Inc.] Press Release The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended broadening the existing marketing authorisation for Darzalex® for use as frontline therapy. [Janssen Global Services, LLC (Business Wire, Inc.)] Press Release Astex Pharmaceuticals, and Otsuka Pharmaceutical Co. Ltd., announced top-line results from the ASTRAL-1 study evaluating the efficacy and safety of guadecitabine in adults with previously untreated acute myeloid leukemia (AML) who are not eligible for intensive induction chemotherapy. [Astex Pharmaceuticals] Press Release The agreement will provide distribution for Endari, the first FDA-approved treatment for sickle cell disease in nearly 20 years, to military personnel and beneficiaries with sickle cell disease. [Emmaus Medical, Inc (Business Wire, Inc.)] Press Release | |
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POLICY NEWSFederal Scientists to Be Protected Against Muzzling, Political Interference All federal departments and agencies with ten or more employees that do science- or research-related activities will have to have a scientific integrity policy by Dec. 31, 2018, based on a new model policy released by the federal Liberal government. [CBC/Radio-Canada] Editorial Global South Scholars Are Missing from European and US Journals. What Can Be Done about It Researchers based in the global North have a wider global reach and are generally judged to be at the forefront of knowledge production and dissemination. Meanwhile, South-based scholars are often not part of major debates and conversations in their field. This points to a severe imbalance in the production of new knowledge. [The Conversation] Editorial Springer Nature Creates New Role to Lead On Research Integrity As one of the largest publishers of academic research, Springer Nature has developed a new position of Research Integrity Director to ensure the growing volume of scientific content being published continues to be rigorously assessed, with robust processes in place to prevent and address research misconduct and breaches of publication ethics. [Springer Nature] Editorial
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EVENTSNEW 4th Annual International Conference on New Concepts in Lymphoid Malignancies: Focus on Aggressive Lymphomas Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Leukemia Research (Oslo University Hospital) Research Technicians – Hematopoiesis (Fred Hutchinson Cancer Research Center) Research Assistant – Stem Cell Biology (NUI Galway) Postdoctoral Researcher – Stem Cell Biology (NUI Galway) Postdoctoral Research Fellow – Hematopoiesis (Fred Hutchinson Cancer Research Center) Endowed Chair – Cancer Research (University of Iowa Health Care) Career Development Program – Glycoscience (BloodCenter of Wisconsin) Research Fellow – Stem Cell Biology & Engineering (New York Blood Center) Postdoctoral Researcher – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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