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Pulmonary Cell News| Hematopoiesis News 9.33 August 21, 2018 | |
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TOP STORYTargeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy Researchers demonstrated that metal response element binding transcription factor 2/polycomblike 2 (MTF2/PCL2) plays a fundamental role in the polycomb repressive complex 2 and that its loss elicits an altered epigenetic state underlying refractory acute myeloid leukemia. [Cancer Discov] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Consistent with a role for inflammatory signals in promoting myeloid differentiation of hematopoietic stem and progenitor cells (HPSCs), cohesin mutations in HSPCs led to reduced inflammatory gene expression and increased resistance to differentiation-inducing inflammatory stimuli. [Nat Immunol] Abstract Circular RNA Expression in Human Hematopoietic Cells Is Widespread and Cell-Type Specific Investigators provide the first comprehensive analysis of circular RNA (circRNA) expression in human hematopoietic progenitors, and in differentiated lymphoid and myeloid cells. They showed that the expression of circRNA is cell-type specific, and increases upon maturation. [Nucleic Acids Res] Full Article The authors showed an activated form of tyrosyl-tRNA synthetase, prepared either by rationally designed mutagenesis or alternative splicing, induces expansion of a previously unrecognized high-ploidy Sca-1+ megakaryocyte population capable of accelerating platelet replenishment after depletion. [Proc Natl Acad Sci USA] Full Article Researchers report a novel role for zinc finger protein 521 in regulating the earliest stages of hematopoiesis and lymphoid cell development via a cell-extrinsic mechanism. [Mol Cell Biol] Abstract Scientists examined the time course of improvements in glucose tolerance and associated changes in β-cell mass and proliferation following transplantation of equivalent numbers of HSCs or mesenchymal stem cells from the same bone marrow into diabetic non-obese diabetic severe combined immune deficiency (NOD.SCID) mice. [Islets] Abstract To better quantify efforts in augmenting β-globin expression, researchers report the creation of a β-globin reporter induced pluripotent stem cell (iPSC) line that allows for the mapping of β-globin expression throughout human erythropoietic development in real time at single-cell resolution. [Blood Adv] Full Article | Graphical Abstract CLINICAL RESEARCHInvestigators examined 100 newly diagnosed acute myeloid leukemia patients to evaluate the impact of p53 expression status quantified in bone marrow core biopsy samples using immunohistochemistry and computer‐assisted image analysis. [Am J Hematol] Abstract Researchers evaluated extramedullary relapses and its features in an allogeneic HSC transplantation cohort, which consisted of patients with acute leukemia and advanced-phase chronic myeloid leukemia. [Bone Marrow Transplant] Abstract Outcome of Allogeneic Hematopoietic Cell Transplantation in Patients with Adult T Cell Leukemia Investigators retrospectively analyzed the outcome of 21 patients with adult T cell leukemia/lymphoma who had undergone allogeneic hematopoietic stem cell transplantation at their hospital during a three‐year period. [Hematol Oncol] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSAge-Related Clonal Hematopoiesis: Implications for Hematopoietic Stem Cell Transplantation Recently, aging has been linked with the development of age-related clonal hematopoiesis (ARCH), defined as the gradual clonal expansion of hematopoietic stem and progenitor cells carrying recurrent disruptive genetic variants in individuals without a diagnosis of hematologic malignancy. The authors review the implications of ARCH in the context of HSC transplantation. [Curr Opin Hematol] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSTolero Pharmaceuticals, Inc. has entered into a clinical research collaboration with AbbVie, exploring the potential of combination therapy with AbbVie’s venetoclax and Tolero’s investigational agent, alvocidib, for the treatment of relapsed/refractory acute myeloid leukemia. [Tolero Pharmaceuticals, Inc.] Press Release Lixte Biotechnology Holdings, Inc. announced that it has entered into a Clinical Trial Agreement and Exclusive License Agreement with Moffitt Cancer Center to conduct a Phase Ib/II study of the safety and therapeutic benefit of Lixte’s lead clinical compound, LB-100, in patients with myelodysplastic syndrome [Lixte Biotechnology Holdings, Inc. (GlobeNewswire, Inc.)] Press Release £3M Award for Pioneering Scottish Leukemia Trial Researchers at the University of Glasgow’s Institute of Cancer Sciences have been awarded £3.1 million by Cancer Research UK to lead a pioneering study to help find new treatments for chronic myeloid leukemia. [University of Glasgow] Press Release Trovagene, Inc. announced completion of the second dosing cohort of onvansertib, a first-in-class, 3rd generation, highly-selective oral polo-like kinase 1 inhibitor, in combination with standard-of-care low-dose cytarabine, in its Phase Ib/II clinical trial in patients with acute myeloid leukemia. [Trovagene, Inc.] Press Release ASLAN Pharmaceuticals announced that the FDA has granted ASLAN003 Orphan Drug Designation as a treatment for acute myeloid leukemia. [ASLAN Pharmaceuticals] Press Release The American Society of Hematology will recognize Victor Hoffbrand, DM, FRCP, FMed Sci, of University College London with the 2018 Wallace H. Coulter Award for Lifetime Achievement in Hematology. Dr. Hoffbrand will be honored for his significant contributions to hematology in research, patient care, and education throughout his 55-year career. [American Society of Hematology] Press Release Connie J. Eaves, PhD, to Present the 2018 American Society of Hematology E. Donnall Thomas Lecture The American Society of Hematology will honor Connie J. Eaves, PhD, FRS (Canada), Corresponding FRS (Edinburgh), of BC Cancer and the University of British Columbia, with the 2018 E. Donnall Thomas Lecture and Prize for her outstanding contributions to the field of hematopoiesis and stem cell research. [American Society of Hematology] Press Release | |
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POLICY NEWSSalk Institute Asks Judge to Narrow Scope of Gender-Discrimination Suit Lawyers representing the Salk Institute for Biological Studies went to court, asking a judge to narrow the scope of a gender-discrimination lawsuit filed by molecular biologist Beverly Emerson. [Nature News] Editorial Top Geneticist Loses £3.5-Million Grant in First Test of Landmark Bullying Policy One of the world’s largest research-funding charities has revoked a £3.5-million (US$4.5-million) grant awarded to a top cancer geneticist, Nazneen Rahman, following allegations that she bullied scientists and other staff when she worked at the Institute of Cancer Research in London. [Nature News] Editorial What Pakistan’s New Government Means for Science Pakistan is reeling from a political earthquake — and researchers are both nervous and excited. The incoming administration promises to use science to alleviate poverty, but it is facing an imminent economic crisis. [Nature News] Editorial The NIH Loosens Grip on Gene Therapy Trials The directors of the National Institutes of Health (NIH) and the US FDA propose limiting the role of the NIH in assessing proposals for gene therapy experiments, the two explain in a commentary in the New England Journal of Medicine. [The Scientist] Editorial
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EVENTSNEW Standardization of the Hematopoietic Progenitor Assay NEW Standardization of the Hematopoietic Progenitor Assay Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESFaculty Position – Hematopathologist (St. Jude Children’s Research Hospital) Postdoctoral Researcher – Molecular Hematology (Lund University) Postdoctoral Fellow – Aging of Hematopoietic Stem Cells (City of Hope) Research Technicians – Hematopoiesis (Fred Hutchinson Cancer Research Center) Postdoctoral Research Fellow – Hematopoiesis (Fred Hutchinson Cancer Research Center) Endowed Chair – Cancer Research (University of Iowa Health Care) Career Development Program – Glycoscience (BloodCenter of Wisconsin) Postdoctoral Researcher – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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