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Pulmonary Cell News| Hematopoiesis News 9.35 September 4, 2018 | |
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TOP STORYResearchers found two daily peaks of bone marrow (BM) hematopoietic stem and progenitor cell (HSPC) activity that are initiated by onset of light and darkness providing this coupling. Both peaks followed transient elevation of BM norepinephrine and TNF secretion, which temporarily increased HSPC reactive oxygen species (ROS) levels. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that P38α restrained erythropoiesis in mouse and human erythroblasts independently of erythropoietin by integrating apoptotic signals during recovery from anemia. [Nat Commun] Full Article To better comprehend neutrophil functions and their regulation, the authors provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors to mature circulating cells [Cell Rep] Full Article | Graphical Abstract Using a murine model of myelodysplastic syndrome investigators demonstrated that constitutive hedgehog/Gli1 activation accelerated leukemic transformation and decreased overall survival. [Oncogene] Abstract Cell lines harboring E1099K exhibited increased H3K36 dimethylation and reduced H3K27 trimethylation, particularly on nucleosomes containing histone H3.1. Mutant NSD2 cells exhibited reduced apoptosis and enhanced proliferation, clonogenicity, adhesion, and migration. [Oncogene] Abstract Researchers established an oncogenic N-MYC-driven B-cell acute lymphoblastic leukemia mouse model, which was subsequently treated with the common chemotherapy drugs cytarabine and daunorubicin. [J Exp Clin Cancer Res] Full Article Administration of CD68-ET3-LV-transduced, stem cell antigen-1+ cells to hemophilia A mice resulted in sustained plasma fVIII production and hemostatic correction without signs of toxicity. [Hum Gene Ther] Abstract Strap Associates with Csde1 and Affects Expression of Select Csde1-Bound Transcripts The authors identified the cold shock domain protein e1 (Csde1)-containing protein complexes and investigated their role in post-transcriptional expression control of Csde1-bound transcripts. [PLoS One] Full Article CLINICAL RESEARCHEmicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors Emicizumab is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. In a Phase III, multicenter trial, scientists investigated its use as prophylaxis in persons who have hemophilia A without factor VIII inhibitors. [N Engl J Med] Abstract | Press Release Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSThe author summarizes the current clinical experience in the use of autologous hematopoietic stem cell transplantation in autoimmune disease and explores the concept of durable remission induction and tissue de-remodeling via restoration of normal niche function and “immune reset.” [Curr Opin Hematol] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSBayer announced that the FDA has approved Jivi® for the routine prophylactic treatment of hemophilia A in previously treated adults and adolescents 12 years of age or older in the U.S. [Bayer] Press Release Novartis announced that the European Commission has approved Kymriah®. The approved indications are for the treatment of pediatric and young adult patients up to 25 years of age with B-cell acute lymphoblastic leukemia that is refractory, in relapse post-transplant or in second or later relapse. [Novartis AG] Press Release | |
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POLICY NEWSRadical Open-Access Plan Could Spell End to Journal Subscriptions Research funders from France, the United Kingdom, the Netherlands and eight other European nations have unveiled a radical open-access initiative that could change the face of science publishing in two years — and which has instantly provoked protest from publishers. [Nature News] Editorial World Bank Pours Hundreds of Millions into African Science A World Bank scheme aimed at building grassroots research capacity in Africa will nearly double its budget with a third, and probably final, investment worth at least US$280 million. [Nature News] Editorial
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EVENTSNEW Applications of the Hematopoietic Progenitor Assay NEW Standardization of the Hematopoietic Progenitor Assay NEW Applications of the Hematopoietic Progenitor Assay NEW Standardization of the Hematopoietic Progenitor Assay NEW Standardization of the Hematopoietic Progenitor Assay Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Assistant – Hematopoietic Stem Cell Biology (University of Oxford) Senior Scientist – CAR T-Cell Research (CELLECTIS Inc.) Faculty Position – Hematopathologist (St. Jude Children’s Research Hospital) Postdoctoral Researcher – Molecular Hematology (Lund University) Postdoctoral Fellow – Aging of Hematopoietic Stem Cells (City of Hope) Research Technicians – Hematopoiesis (Fred Hutchinson Cancer Research Center) Postdoctoral Research Fellow – Hematopoiesis (Fred Hutchinson Cancer Research Center) Postdoctoral Researcher – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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