Hematopoiesis News 9.38 September 25, 2018 | |
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TOP STORYBcor Insufficiency Promotes Initiation and Progression of Myelodysplastic Syndrome BcorΔE9-10/y mice developed lethal T-cell lymphoblastic leukemia in a similar manner to BcorΔE4/y mice, while BcorΔE9-10/y hematopoietic cells showed a growth advantage in the myeloid compartment that was further enhanced by the concurrent deletion of Tet2. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists reveal that Lnk (Sh2b3) deficiency restores HSC function in Fancd2−/− mice. Lnk deficiency did not impact interstrand crosslink repair, but instead stabilized stalled replication forks in a manner, in part, dependent upon alleviating blocks to cytokine-mediated JAK2 signaling. [Nat Commun] Full Article Cdc42 activity-specific inhibitor inhibited intracellular Cdc42 activity specifically and transiently to induce murine hematopoietic stem/progenitor cell egress from the bone marrow by suppressing actin polymerization, adhesion, and directional migration of stem/progenitor cells, conferring Cdc42 knockout phenotypes. [Leukemia] Abstract | Press Release Aging Alters the Epigenetic Asymmetry of HSC Division Scientists demonstrated—using a comprehensive set of paired daughter cell analyses that include single-cell 3D confocal imaging, single-cell transplants, single-cell RNA-seq, and single-cell transposase-accessible chromatin sequencing—that the outcome of HSC divisions is strongly linked to the polarity status before mitosis, which is in turn determined by the level of the activity cell division control protein 42 in stem cells. [PLoS Biol] Full Article Mouse Adult Hematopoietic Stem Cells Actively Synthetize Ribosomal RNA Investigators showed that Flow-FISH reports and quantifies ribosome biogenesis activity in hematopoietic cell populations, thereby providing original data on this fundamental process notably in rare populations such as hematopoietic stem and progenitor cells. [RNA] Abstract Cell Cycle and Differentiation of Sca-1+ and Sca-1− Hematopoietic Stem and Progenitor Cells Division of the Sca-1+ progenitors led to loss of the Sca-1 marker in about half of newly produced cells, corresponding to asymmetric cell division. Sca-1− cells arising from cell division entered a new round of the cell cycle, corresponding to symmetric self-renewing cell division. [Cell Cycle] Abstract | Graphical Abstract The Human Cell Atlas Bone Marrow Single-Cell Interactive Web Portal Using the first data release from the HCA bone marrow tissue project, scientists resolved common, rare and potential transitional cell populations from over 100,000 hematopoietic cells, spanning 35 transcriptionally coherent groups across 8 healthy donors using emerging new computational approaches. [Exp Hematol] Abstract Investigators aimed to generate of megakaryocytes and platelets from human HSCs. The purity of HSCs was assessed through flow cytometry and immunocytochemistry studies. [Biochem Biophys Res Commun] Abstract | Graphical Abstract CLINICAL RESEARCHEfficacy of an ambulatory hematopoietic stem cell transplant program with a reduced intensity conditioning regimen in malignant hematological diseases was assessed. [Bone Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSNecroinflammation Emerges as a Key Regulator of Hematopoiesis in Health and Disease The authors highlight recent developments and open questions at the interplay between inflammation, regulated necrosis, and HSC biology in the context of blood cell development, acute and chronic inflammation, and hematopoietic cancer. [Cell Death Differ] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSuniQure Provides Update on Dose-Confirmation Study of AMT-061 in Patients with Hemophilia B uniQure N.V. announced that the third patient has been treated in the company’s Phase IIb dose-confirmation study of AMT-061, an investigational AAV5-based gene therapy incorporating the FIX-Padua variant for the treatment of patients with severe and moderately severe hemophilia B. [uniQure N.V.] Press Release Amgen announced that the Japanese Ministry of Health, Labour and Welfare has granted marketing approval for BLINCYTO® for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia. BLINCYTO was developed in Japan by Amgen Astellas BioPharma K.K., a joint venture between Amgen and Astellas Pharma Inc. [Amgen Inc.] Press Release | |
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POLICY NEWSTrump Administration Launches Review of Scientific Research Involving Fetal Tissue The Trump administration has launched a comprehensive review of all research that involves fetal tissue, reopening an issue that has galvanized anti-abortion activists but worried scientists who fear their work could be under threat. [STAT News] Editorial More and More Scientists Are Preregistering Their Studies. Should You? Preregistration, in its simplest form, is a one-page document answering basic questions such as: What question will be studied? What is the hypothesis? What data will be collected, and how will they be analyzed? In its most rigorous form, a “registered report,” researchers write an entire paper, minus the results and discussion, and submit it for peer review at a journal, which decides whether to accept it in principle. [ScienceInsider] Editorial
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EVENTSNEW Making it Personal: Cancer Precision Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Myelodysplasia and Acute Myeloid Leukemia (University of New South Wales) NEW Postdoctoral Fellow – Immunology/Hematopoiesis (Lund University) Postdoctoral Position – Stem Cells, Development and Cancer (Albert Einstein College of Medicine) Postdoctoral Fellow – Leukemic Stem Cell Biology (McGill University) Research Assistant – Hematopoietic Stem Cell Biology (University of Oxford) Senior Scientist – CAR T-Cell Research (CELLECTIS Inc.) Faculty Position – Hematopathologist (St. Jude Children’s Research Hospital) Postdoctoral Researcher – Molecular Hematology (Lund University) Postdoctoral Fellow – Aging of Hematopoietic Stem Cells (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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