| Vol. 12.04 – 02 February, 2021 |
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| Researchers conducted a pooled CRISPR screen in human hematopoietic stem and progenitor cells that correlated ELANE mutations with neutrophil maturation potential. [Cell Stem Cell] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs. Loss of neogenin-1 initially leads to increased HSC expansion but subsequently to loss of self-renewal and premature exhaustion in vivo. [Nature Communications] |
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| Scientists integrated in situ Hi-C and nine additional omics layers. Beyond conventional active and inactive compartments, they uncovered a highly-dynamic intermediate compartment enriched in poised and polycomb-repressed chromatin. [Nature Communications] |
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| Investigators demonstrated for the first time that TGF-β-PAI-1 axis was selectively augmented in chronic myeloid leukemia (CML) in the bone marrow, whereby protecting CML-leukemia stem cells from tyrosine kinase inhibitor treatment. [Haematologica] |
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| Scientists revealed that miR-21 deficiency markedly decreases the NF-κB pathway, accompanied by increased expression of PDCD4, a direct target of miR-21, in HSCs. [Haematologica] |
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| The authors demonstrated that megakaryocytes possess a functional necroptosis signaling cascade. Necroptosis activation led to phosphorylation of mixed lineage kinase domain-like, loss of viability and cell swelling. [Cell Death & Disease] |
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| Researchers generated CD34+ progenitor cells from two different embryonic stem cell lines, WA01 and WA09, to circumvent limitations associated with primary CD34+ hematopoietic progenitor cells. [Journal of Virology] |
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| The authors describe the results of varying the proportion of bone marrow mesenchymal stem cells to CD34+ hematopoietic stem/progenitor cells co-seeded onto synthetic poly(1,8 octamethylene citrate) or small intestinal submucosa scaffolds and their contribution to bladder tissue regeneration. [Scientific Reports] |
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| Investigators measured the radiation response of T cells, B cells, NK cells, CD34+ progenitor cells and monocytes obtained from peripheral blood and monocyte-derived macrophages and immature dendritic cells ex vivo and showed that T and B cells were highly sensitive, starting to undergo apoptosis following ionizing radiation with a dose as low as 0.125 Gy. [Scientific Reports] |
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| When comparing the global gene expression of recently divided chronic lymphocytic leukemia cells with that of previously divided cells, researchers found higher levels of genes involved in regulating gene expression. [Leukemia] |
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| Understanding how certain extra-oral pathologies are affected by disseminated periodontal pathogens and periodontitis-associated systemic inflammation, including adaptation of bone marrow hematopoietic progenitors, may provide new therapeutic options to reduce the risk of periodontitis-associated comorbidities. [Nature Reviews Immunology] |
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| Investigators highlight how mitochondrial and metabolic pathways function as a central mediator to control gene expression, specifically on stem cell functions, differentiation and immune response in leukemia. [Cancer Discovery] |
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| The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency will perform an accelerated assessment of the Marketing Authorisation Application for the B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy ciltacabtagene autoleucel. [Janssen Pharmaceutical Companies of Johnson & Johnson] |
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| The International Society for Stem Cell Research (ISSCR) awarded the 2021 Tobias Lecture Award to Stuart H. Orkin, MD, Boston Children’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School. “Stuart is one of the most accomplished and innovative physician-scientists in the world engaged in hematopoiesis research,” said Christine Mummery, ISSCR President. [The International Society for Stem Cell Research (EurekAlert!)] |
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February 3 – 5, 2021 Virtual |
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| University of Oxford – Oxford, England, United Kingdom |
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| Blood Research Institute – Milwaukee, Wisconsin, United States |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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| Harvard Medical School – Boston, Massachusetts, United States |
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