| Vol. 5.12 – 9 April, 2021 |
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| The authors demonstrated that selective histone deacetylase 8 (HDAC8) inhibition elicited effective and durable responses to immune-checkpoint blockade by co-opting adaptive immunity through enhancer reprogramming. [Science Translational Medicine] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the role of tumor necrosis factor‐α‐induced protein 8‐like 2 in the development of nonalcoholic fatty liver disease. [Hepatology] |
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| Scientists identified aldolase A (ALDOA), a key enzyme in glycolysis and gluconeogenesis, as an essential driver for hepatocellular carcinoma cell growth under hypoxia. [Hepatology] |
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| Researchers showed that Pah-R261Q hepatic tissue exhibited large ubiquitin-positive, amyloid-like oligomeric aggregates of mutant phenylalanine hydroxylase that colocalized with selective autophagy markers. [Nature Communications] |
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| A highly selective, safe, and potent CXC chemokine receptor 4 (CXCR4) antagonist, BPRCX807, has been designed and experimentally validated in various hepatocellular carcinoma models. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned mesenchymal stromal cells (γ-sEVs). [NPJ Regenerative Medicine] |
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| Scientists demonstrated that gene related to anergy in lymphocytes (GRAIL) regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1 (Sirt1). [Cell Death & Disease] |
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| The authors investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis. [Cell Death & Disease] |
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| Researchers found that mechanical homeostasis, which is crucial for organ morphogenesis and functioned in various phenomena, played essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks. [Communications Biology] |
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| The authors discuss the cellular sources of extracellular vesicles (EV), provide a concise overview of their potential use in diverse processes, and outline several promising applications for the use of EV based therapeutics for liver diseases. [Hepatology] |
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| UniQure has concluded that a virus used widely in gene therapy was very unlikely to have caused liver cancer in a hemophilia patient in a clinical trial. [Science] |
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| June 14 – 18, 2021 Virtual |
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| | | | Beam Therapeutics – Cambridge, Massachusetts, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Spark Therapeutics – Philadelphia, Pennsylvania, United States |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | CyberCoders – San Diego, California, United States |
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