Hepatic Cell New Volume 5.12 | Apr 9 2021

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    2021-04-9| HCN 5.12


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.12 – 9 April, 2021
    TOP STORY

    A Selective HDAC8 Inhibitor Potentiates Antitumor Immunity and Efficacy of Immune Checkpoint Blockade in Hepatocellular Carcinoma

    The authors demonstrated that selective histone deacetylase 8 (HDAC8) inhibition elicited effective and durable responses to immune-checkpoint blockade by co-opting adaptive immunity through enhancer reprogramming.
    [Science Translational Medicine]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Tumor Necrosis Factor‐α‐Induced Protein 8‐Like 2 Alleviates Nonalcoholic Fatty Liver Disease via Suppressing TAK1 Activation

    Researchers investigated the role of tumor necrosis factor‐α‐induced protein 8‐like 2 in the development of nonalcoholic fatty liver disease.
    [Hepatology]

    Abstract

    Loss-of-Function Genetic Screening Identifies ALDOA as an Essential Driver for Liver Cancer Cell Growth under Hypoxia

    Scientists identified aldolase A (ALDOA), a key enzyme in glycolysis and gluconeogenesis, as an essential driver for hepatocellular carcinoma cell growth under hypoxia.
    [Hepatology]

    Full Article

    The Pah-R261Q Mouse Reveals Oxidative Stress Associated with Amyloid-Like Hepatic Aggregation of Mutant Phenylalanine Hydroxylase

    Researchers showed that Pah-R261Q hepatic tissue exhibited large ubiquitin-positive, amyloid-like oligomeric aggregates of mutant phenylalanine hydroxylase that colocalized with selective autophagy markers.
    [Nature Communications]

    Full Article
    Press Release

    A Highly Selective and Potent CXCR4 Antagonist for Hepatocellular Carcinoma Treatment

    A highly selective, safe, and potent CXC chemokine receptor 4 (CXCR4) antagonist, BPRCX807, has been designed and experimentally validated in various hepatocellular carcinoma models.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Small Extracellular Vesicles Derived from Interferon-γ Pre-Conditioned Mesenchymal Stromal Cells Effectively Treat Liver Fibrosis

    Investigators analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned mesenchymal stromal cells (γ-sEVs).
    [NPJ Regenerative Medicine]

    Full Article

    E3 Ubiquitin Ligase Grail Promotes Hepatic Steatosis through Sirt1 Inhibition

    Scientists demonstrated that gene related to anergy in lymphocytes (GRAIL) regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1 (Sirt1).
    [Cell Death & Disease]

    Full Article

    Synergistic Effect of the TLR5 Agonist CBLB502 and Its Downstream Effector IL-22 against Liver Injury

    The authors investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
    [Cell Death & Disease]

    Full Article

    Mechanical Homeostasis of Liver Sinusoid Is Involved in the Initiation and Termination of Liver Regeneration

    Researchers found that mechanical homeostasis, which is crucial for organ morphogenesis and functioned in various phenomena, played essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks.
    [Communications Biology]

    Full Article
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    REVIEWS

    Biological Nanotherapeutics for Liver Disease

    The authors discuss the cellular sources of extracellular vesicles (EV), provide a concise overview of their potential use in diverse processes, and outline several promising applications for the use of EV based therapeutics for liver diseases.
    [Hepatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Experimental Gene Therapy for Hemophilia Probably Did Not Cause Patient’s Liver Tumor

    UniQure has concluded that a virus used widely in gene therapy was very unlikely to have caused liver cancer in a hemophilia patient in a clinical trial.
    [Science]

    Press Release
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    JOB OPPORTUNITIES

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