Hepatic Cell News 1.25 July 21, 2017 | |
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TOP STORYEngineered Liver Tissue Expands after Transplant Researchers at MIT, Rockefeller University, and Boston University have developed a new way to engineer liver tissue, by organizing tiny subunits that contain three types of cells embedded into a biodegradable tissue scaffold. [Press release from MIT discussing online prepublication in Science Translational Medicine] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. [Mol Cell] Abstract | Graphical Abstract It has been reported that long non-coding RNA cancer susceptibility candidate 2 (CASC2) participates in regulating carcinogenesis and suppresses tumor progression by sponging microRNAs. The expression of CASC2 and miR-367 in HCC specimens and cell lines were detected by real-time PCR. The correlations among CASC2, miR-367 and F-box and WD repeat domain containing 7 (FBXW7) were disclosed by a dual-luciferase reporter assay, RIP assay and biotin pull-down assay. [Mol Cancer] Full Article ENMD-1068 Inhibits Liver Fibrosis through Attenuation of TGF-β1/Smad2/3 Signaling in Mice Investigators studied the effect of N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine on the development of CCl4-induced liver fibrosis in mice and activation of hepatic stellate cells isolated from the mice. [Sci Rep] Full Article TRAIL Regulatory Receptors Constrain Human Hepatic Stellate Cell Apoptosis Researchers dissected the contribution of regulatory TRAIL receptors to apoptosis resistance in primary human hepatic stellate cells. [Sci Rep] Full Article By introducing a set of reprogramming factors, investigators established HuH-7-derived oval-like cell lines, Hdo-17 and -23, which possess features of bipotential liver precursors. [Oncotarget] Full Article Therapeutic Vaccine to Cure Large Mouse Hepatocellular Carcinomas The authors report the development of a therapeutic vaccination regimen consisting of intratumoral delivery of high-mobility group nucleosome-binding protein 1, R848/resiquimod, and one checkpoint inhibitor. [Oncotarget] Full Article Scientists showed that normal small Lewis grafts transplanted to alcohol fed Lewis hosts developed fibrosis whereas no fibrosis was observed in control fed recipients. [Liver Transpl] Abstract Researchers demonstrated that the Malat1-miR-195-EGFR axis plays a critical role in hepatocellular carcinoma (HCC) cells which provided a better understanding of metastasis-associated lung adenocarcinoma transcription 1 (Malat1) posttranscriptional regulation in HCC. [J Cell Biochem] Abstract Investigators report that hypoxia (1% O2) caused 2.55–489.7-fold resistance to six anticancer drugs (sorafenib, 5-fluorouracil, gemcitabine, cisplatin, adriamycin and 6-thioguanine) in three hepatocellular carcinoma cell lines (BEL-7402, HepG2 and SMMC-7721). [Acta Pharmacol Sin] Abstract Scientists found that β-mangostin did not induce cytotoxicity in human hepatocellular carcinoma cells (SK-Hep-1, Huh-7 and HA22T/VGH cells). [Environ Toxicol] Abstract | |
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REVIEWSStable Isotope-Based Flux Studies in Nonalcoholic Fatty Liver Disease Investigators focus mainly on the utilization of mass spectrometry-based methods for the understanding of metabolic abnormalities in the different stages of nonalcoholic fatty liver disease. [Pharmacol Ther] Abstract The authors discuss the relationship between wound healing and metastasis using liver as an example to illustrate how injury steers the phenotype of liver endothelium and perivascular hepatic stellate cells to a potentially pro-metastatic one. [Curr Opin Cell Biol] Abstract Radiation-Induced Liver Disease: Current Understanding and Future Perspectives Researchers introduce the concept and clinical characteristics of radiation-induced liver disease (RILD) and propose a feasible explanation for RILD pathogenesis. In addition, currently available animal models of RILD are reviewed, focusing on similarities with human RILD and clues to understanding the mechanisms of RILD progression. [Exp Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
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INDUSTRY NEWSWorld Hepatitis Day 2017: Eliminate Hepatitis The World Hepatitis Day on 28 July 2017 is an opportunity to add momentum to all efforts to implement the WHO’s first global health sector strategy on viral hepatitis for 2016-2021 and help Member States achieve the final goal – to eliminate hepatitis. [WHO] Press Release FDA Approves Vosevi for Hepatitis C The U.S. Food and Drug Administration approved Vosevi to treat adults with chronic hepatitis C virus genotypes 1-6 without cirrhosis or with mild cirrhosis. [FDA] Press Release Tiziana Life Sciences plc announced the enrolment of the first patient in its phase IIa clinical trial with milciclib, a novel inhibitor of cyclin-dependent kinases (CDKs), in patients with refractory hepatocellular carcinoma. [Tiziana Life Sciences plc] Press Release Can-Fite BioPharma Ltd. announced that it successfully concluded a clinical investigator meeting with the principal investigators, researchers, and doctors participating as clinical investigators in the Company’s phase II trial of its drug candidate namodenoson in the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). [Can-Fite BioPharma Ltd.] Press Release Huch Lab Wins Project Grant to Develop Patient-Specific ‘Liver Cancer Organoids’ The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) has awarded a project grant to Meri Huch to explore how to grow liver cancer organoids from tumour biopsies, replacing the use of animals for such research. [The Gurdon Institute] Press Release | |
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POLICY NEWSSome Scientists Hate NIH’s New Definition of a Clinical Trial. Here’s Why Scientists in behavioral research fields — from cognitive psychology to vision science — were dismayed to learn that the U.S. National Institutes of Health (NIH) in Bethesda, Maryland, could soon deem their studies to be clinical trials. [ScienceInsider] Editorial Salk Institute Hit with Discrimination Lawsuit by Third Female Scientist Following two gender discrimination lawsuits filed last week, a third senior female professor at the Salk Institute for Biological Studies has similarly sued the storied independent institute in San Diego, California. [ScienceInsider] Editorial
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EVENTSNEW 5th Annual European Congress on Clinical & Translational Sciences (EUSTM-2017) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Assistant/Associate – Immuno-Oncology of Liver Cancer (Newcastle University) Post-Doctoral Scholarship – Chronic Viral Hepatitis (Karolinska Institutet) Postdoc or PhD Position – Cancer Research (University Medical Center Groningen) Postdoctoral Researcher – Cancer and Epigenetics (St. Anne’s University Hospital) Postdoctoral Associate – Gene Therapy (University of Massachusetts Medical School) Research Fellow – Cancer Research (National University of Singapore) Academic Pathologist – Liver/GI (University of Texas Southwestern Medical Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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