Hepatic Cell News Volume 1.28 | Aug 11 2017

TOP STORY

Oncostatin M Causes Liver Fibrosis by Regulating Cooperation between Hepatic Stellate Cells and Macrophages in Mice

Researchers showed that oncostatin M (OSM) exerts powerful fibrogenic activity by regulating macrophage activation during chronic liver injury. Genetic ablation of the OSM gene alleviated fibrosis in a mouse model of chronic hepatitis. [Hepatology] Abstract

(Ranked by impact factor of the journal)

The PDGFRα-Laminin B1-Keratin 19 Cascade Drives Tumor Progression at the Invasive Front of Human Hepatocellular Carcinoma

Scientists focused on the functional role of the PDGFRα-La/SSB-LAMB1 pathway and its molecular link to K19 expression in human hepatocellular carcinoma. [Oncogene] Full Article

TRIF-Dependent Toll-Like Receptor Signaling Suppresses Scd1 Transcription in Hepatocytes and Prevents Diet-Induced Hepatic Steatosis

Investigators found that deficiency in TIR domain–containing adaptor-inducing interferon-β (TRIF), a cytosolic adaptor that transduces some toll-like receptor signals, worsened hepatic steatosis induced by a high-fat diet and that such exacerbation was independent of myeloid cells. [Sci Signal] Abstract

CREB3L2-Mediated Expression of Sec23A/Sec24D Is Involved in Hepatic Stellate Cell Activation through ER-Golgi Transport

Researchers revealed that differentiation alters early secretory gene expression. They observed significant isoform-specific upregulation of the inner coat protein complex II components, Sec23A and Sec24D, via the transmembrane bZIP transcription factor, CREB3L2/BBF2H7, during hepatic stellate cell activation. [Sci Rep] Full Article

Up-Regulation of BRCA1-Associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling

The authors investigated the potential clinical, pathological, prognostic value, role and mechanism of BRCA1-associated RING Domain 1 in hepatocellular carcinoma. [Sci Rep] Full Article

Hepatitis C Virus Core Protein Modulates Endoglin (Cd105) Signaling Pathway for Liver Pathogenesis

It has been shown that hepatitis C virus (HCV) infection induces epithelial-mesenchymal transition state and cancer stem-like cell properties in human hepatocytes. Scientists observed increased endoglin expression on the cell surface of HCV core expressing hepatocellular carcinoma cell line or immortalized human hepatocytes and activation of its downstream signaling molecules. [J Virol] Abstract

The Novel Resveratrol Derivative 3,5-Diethoxy-3′,4′-Dihydroxy-Trans-Stilbene Induces Mitochondrial ROS-Mediated ER Stress and Cell Death in Human Hepatoma Cells In Vitro

Researchers analyzed the cell death-inducing mechanisms of resveratrol-006, a novel resveratrol derivative in human liver cancer cells in vitro. [Acta Pharmacol Sin] Full Article

Effects of Cancer-Testis Antigen, TFDP3, on Cell Cycle Regulation and its Mechanism in L-02 and HepG2 Cell Lines In Vitro

The authors examined the expression of TFDP3 in human liver tissues. They then detected the expression of TFDP3 at the RNA level and protein level in L-02 cell line and HepG2 cell line, and the location of TFDP3 was defined by immunofluorescence technique. [PLoS One] Full Article

Expression of Cytokine and Extracellular Matrix mRNAs in Fetal Hepatic Stellate Cells

Among cytokines, insulin-like growth factor 2 (Igf2) was highly expressed at all three stages analyzed. Among liver cells, Igf2 was predominantly expressed in hepatoblast-like cells at all three stages examined, suggesting that hepatoblast-like cells are an essential part of the niche that maintains homeostasis of hematopoietic cells in embryonic mouse liver. [Genes Cells] Abstract

Protein Glycosylation in Viral Hepatitis-Related Hepatocellular Carcinoma: Characterization of Heterogeneity, Biological Roles, and Clinical Implications

Researchers review the structural diversity of glycans in viral hepatitis-related hepatocellular carcinoma, discuss their roles in regulating the initiation and development of liver cancer, and introduce potential clinical applications. [Cancer Lett] Abstract

Visit our reviews page to see a complete list of reviews in the hepatic cell research field.

Hepatitis A Vaccination for Alaskan Children has Wiped Out the Virus

A comprehensive hepatitis A vaccination program established in Alaska in the 1990s, which became a requirement for school entry in 2001, has virtually wiped out the virus in the native peoples of Alaska, where it had been endemic. [Press release from the World Hepatitis Alliance discussing research presented at the World Indigenous Peoples’ Conference on Viral Hepatitis in Anchorage, Alaska] Press Release

Cherokee Nation American Indian Tribe Showing it is Possible to Eliminate Hepatitis C

The Cherokee Nation American Indian population is aiming to eliminate hepatitis C virus among its tribal citizens, where already almost half have been screened for the virus and around one quarter of those estimated to be infected have already been cured. [Press release from the World Hepatitis Alliance discussing research presented at the World Indigenous People’s Conference on Viral Hepatitis in Anchorage, Alaska] Press Release

Bayer Receives EU Approval for Stivarga^® (Regorafenib) for the Second-Line Systemic Treatment of Liver Cancer

Bayer announced the European Commission has granted marketing authorization for Stivarga^® for the treatment of adult patients with hepatocellular carcinoma who have been previously treated with Nexavar^®. [Bayer AG] Press Release

Can-Fite Completes Patient Enrolment for Its Phase II Study of Namodenoson in the Treatment of Liver Cancer

Can-Fite BioPharma Ltd. announced that the Phase II liver cancer clinical trial for Namodenoson, a novel compound for the treatment of advanced hepatocellular carcinoma, has successfully enrolled and randomized all 78 patients planned in the clinical trial protocol. [Can-Fite BioPharma Ltd.] Press Release

US Biomedical-Research Facilities Unprepared for Attacks and Natural Disasters

When Hurricane Sandy hit New York City in 2012, the storm destroyed scientific equipment worth more than US$20 million at the New York University Langone Medical Center. Tropical Storm Allison hit the University of Texas Health Science Center in Houston in 2001, and caused so much damage that some researchers had to restart their careers elsewhere. Despite such catastrophes, a report found that many research institutions in the United States are still unprepared for disasters. [Nature News] Editorial

Americans Are Becoming More Open to Human Genome Editing, Survey Finds, but Concerns Remain

Earlier surveys of Americans found a reluctance to support human genome editing, with many respondents expressing ethical and other concerns about such intentional tinkering. A new survey found that two-thirds of the 1600 respondents thought genome editing was generally “acceptable.” But that acceptance was qualified, and colored by religious beliefs and scientific knowledge. [ScienceInsider] Editorial

Thousands across India March in Support of Science

Thousands of scientists, university students and science enthusiasts gathered in dozens of Indian cities to march in support of science — lamenting their country’s low levels of funding for research, and complaining about government promotion of ‘unscientific ideas’. [Nature News] Editorial

NEW Hepatobiliary Cancers: Pathobiology and Translational Advances
December 7-10, 2017
Glen Allen, Virginia, United States

Visit our events page to see a complete list of events in the community.

NEW Senior Lab Manager – Notch Control of Liver Development (Karolinska Institutet)

NEW Research Fellows – Cancer Research (National University of Singapore)

NEW Multiple Positions – Cancer Research (National University of Singapore)

Assistant Professor – Biomedical Research (National Institutes of Health)

Postdoctoral Scholar – Computational Biology/Cancer Genomics (University of Chicago)

Postdoctoral Fellow – Stem Cell Biology (University of Louisville)

Post-Doctoral Research Fellow – Pathogenesis of Metabolic Diseases (Columbia University’s Department of Medicine)

Post-Doctoral Research Fellow – Liver Cancer Pathogenesis and Immunobiology (Fred Hutchinson Cancer Research Center)

Post-Doctoral Scholarship – Chronic Viral Hepatitis (Karolinska Institutet)

Postdoc or PhD Position – Cancer Research (University Medical Center Groningen)

Post-Doctoral Researcher – Cancer and Epigenetics (St. Anne’s University Hospital)

Post-Doctoral Research Fellow – Translational Liver Cancer Research (Fred Hutchinson Cancer Research Center)

Senior Investigator/Investigator III – Molecular Pathology (Novartis Institutes for BioMedical Research)

Academic Pathologist – Liver/GI (University of Texas Southwestern Medical Center)

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