Hepatic Cell News 2.03 January 26, 2018 | |
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TOP STORYResearchers investigated the molecules released through hepatic stellate cell-derived extracellular vesicles (EVs), the mechanism of their release and the role of these EVs in fibrosis. [Hepatology] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators identified that CD147 was basolaterally polarized in hepatocyte membrane of liver tissues and HepG2 cells. CD147 not only promoted the transforming growth factor-β1-mediated hepatocyte polarity loss, but also directly induced endocytosis and downregulation of E-cadherin which contributed to hepatocyte depolarization. [Hepatology] Abstract | Full Article Hepatic stellate cells (HSCs) upregulated transcription and translation of KRT19 in hepatocellular carcinoma (HCC) cells via paracrine interactions. Mechanistically, hepatocyte growth factor (HGF) from HSCs activated c-MET and the MEK-ERK1/2 pathway which upregulated KRT19 expression in HCC cells. [Cancer Res] Abstract Scientists found that BRG1 is upregulated in hepatocellular carcinoma (HCC) and that its level significantly correlates with cancer progression in HCC patients. [Cell Death Dis] Full Article Researchers demonstrated that expression of dihydropyrimidine dehydrogenase, a pyrimidine catabolic enzyme, was dose-dependently downregulated by interferon-α in hepatocellular carcinoma tissues from nude mice. [Cell Death Dis] Full Article A Humanized Mouse Model of Liver Fibrosis following Expansion of Transplanted Hepatic Stellate Cells To investigate whether hepatic stellate cells (HSCs) could engraft and repopulate the liver, scientists transplanted GFP-transduced immortalized human HSCs into immunodeficient NOD/SCID mice. [Lab Invest] Abstract The authors investigated whether autophagy promotes glycolysis in hepatocellular carcinoma cells by activating the Wnt/β-catenin signaling pathway, accompanied by MCT1 upregulation. [J Exp Clin Cancer Res] Full Article Development of a Novel Zebrafish Xenograft Model in Ache Mutants Using Liver Cancer Cell Lines Investigators developed an embryonic zebrafish xenograft model using epithelial and mesenchymal liver cancer cell lines in wild-type and achesb55 sibling mutant larvae after characterization of cholinesterase expression and activity in cell lines and zebrafish larvae. [Sci Rep] Full Article Scientists investigated the anti-cancer property of grape seed extract during early stages of developing liver cancer using a two-stage carcinogenic model combining diethylnitrosamine and 2-acetyl aminofluorene. [Sci Rep] Full Article Researchers reveal a critical role for miR-338-5p in the regulation of multidrug resistance and proliferation of hepatocellular carcinoma (HCC), suggesting the potential therapeutic implications of miR-338-5p in HCC treatment. [Signal Transduct Target Ther] Full Article | |
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REVIEWSScientists discuss the signaling pathways induced by sublethal hepatocyte lipid overload that contribute to the pathogenesis of non-alcoholic steatohepatitis. [Gut] Abstract Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
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SCIENCE NEWSNanobiotix Presents First Promising Data from Phase I/II Liver Cancers Trial of NBTXR3 Nanobiotics announced a first readout of intermediate data on the safety and feasibility in its Phase I/II trial evaluating NBTXR3 in liver cancers, including primary and liver metastasis from other tumors. [Press release from Nanobiotics discussing research presented at the 2018 American Society of Clinical Oncology (ASCO)-Gastrointestinal (GI) Cancers Symposium, San Francisco] Press Release | |
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INDUSTRY NEWSAptima® HBV Quant Assay for Quantitation of Hepatitis B Viral Load Receives PMA Approval Hologic, Inc. announced that the FDA has granted PMA approval for the Aptima® HBV Quant Assay for quantitation of hepatitis B viral load on the fully automated Panther® system. [Hologic, Inc.] Press Release BioAtla Announces FDA Clearance of IND Application for CAB-AXL-ADC Therapeutic BioAtla® LLC announced that the FDA has cleared BioAtla’s Investigational New Drug application (IND) for BA3011, a novel conditionally active AXL-targeted antibody-drug conjugate (CAB-AXL-ADC), in patients with solid tumors. [BioAtla® LLC] Press Release | |
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POLICY NEWSGerman Scientists Hope for Windfall from Incoming Government Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial Nobel Laureate Suggests He Could Fall on Sword over Colleague’s Bogus Paper Shinya Yamanaka, who won a share of the 2012 Noble Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application in Japan over a fraudulent paper published by center researchers. [ScienceInsider] Editorial
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EVENTSNEW Cold Spring Harbor (CSH): Mechanisms & Models of Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Liver Cancer Research (University of California, San Francisco) Locum Chief Editor – Nature Reviews Gastroenterology & Hepatology (Nature Research) Postdoctoral Position – Liver Diseases (University of Illinois) Part-Time Postdoctoral Scientist – HCV Vaccine Model Development (University of Oxford) Postdoctoral Fellow – Liver Cancer (University Health Network) Postdoctoral Scholar Position – Cancer & Stem Cell Epigenomics (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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