Hepatic Cell News Volume 2.48 | Dec 14 2018

TOP STORY

Vagus-Macrophage-Hepatocyte Link Promotes Post-Injury Liver Regeneration and Whole-Body Survival through Hepatic FoxM1 Activation

Scientists showed that a vagus-macrophage-hepatocyte link regulates acute liver regeneration after liver injury and that this system is critical for promoting survival. Hepatic Foxm1 is rapidly upregulated after partial hepatectomy. Hepatic branch vagotomy suppresses this upregulation and hepatocyte proliferation, thereby increasing mortality. [Nat Commun] Full Article

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Hepatitis B Virus X Protein Promotes DNA Damage Propagation through Disruption of Liver Polyploidization and Enhances Hepatocellular Carcinoma Initiation

Researchers studied the role of hepatitis B virus X protein (HBx) expression on the progression of cell cycle and liver polyploidization during proliferation and liver carcinogenesis. Full-length HBx transgenic mice were developed to investigate liver ploidy as well as hepatocyte proliferation, along normal liver maturation and during cancer initiation (chemical carcinogen treatment). [Oncogene] Abstract

Exosome circRNA Secreted from Adipocytes Promotes the Growth of Hepatocellular Carcinoma by Targeting Deubiquitination-Related USP7

Adipose-secreted circRNAs were found to regulate deubiquitination in hepatocellular carcinoma (HCC), thus facilitating cell growth. It was observed that exosome circ-deubiquitination (circ-DB) is upregulated in HCC patients with higher body fat ratios. In vitro and in vivo studies showed that exo-circ-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7. [Oncogene] Full Article

LncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma

The expression levels of lncRNA SNHG8 were dramatically increased in hepatocellular carcinoma (HCC) tissues and cell lines as compared with the adjacent normal tissues, and SNHG8 expression was an independent prognostic factor of tumor recurrence in HCC patients. [Cell Physiol Biochem] Full Article

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver through a SIRT1/ATF6-Dependent Mechanism

There was a significant increase in the accumulation of lipid droplets (LD) in liver and hepatocytes during the process of high-fat diet-induced steatosis, respectively, which was significantly inhibited by resveratrol (RSV) supplementation. RSV notably activated SIRT1 expression and decreased the expression levels of ATF6, Fsp27β/CIDEC, CREBH, and PLIN1, which are associated with LD accumulation. [Cell Physiol Biochem] Full Article

Delphinidin Inhibits Epidermal Growth Factor-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Cells

Investigators found that delphinidin inhibits morphological changes from epithelial to mesenchymal phenotype by epidermal growth factor (EGF). Delphinidin increased the messenger RNA and protein expression of E-cadherin and decreased those of Vimentin and Snail in EGF-induced hepatocellular carcinoma cells. [J Cell Biochem] Abstract

Novel Hepatoprotective Role of Leonurine Hydrochloride against Experimental Non-Alcoholic Steatohepatitis Mediated via Ampk/SREBP1 Signaling Pathway

For in vitro studies, palmitic acid and free fatty acid induced HepG2 and HL7702 steatosis cell models were used. For in vivo studies, NASH was induced by feeding mice MCD diet. These mice received either placebo or LH at three different doses for 6 weeks. [Biomed Pharmacother] Full Article

Gambogenic Acid Reverses P-Glycoprotein Mediated Multidrug Resistance in HepG2/Adr Cells and Its Underlying Mechanism

Results of the MTT method indicated that GNA increased the chemosensitivity of doxorubicin (DOX) and paclitaxel in the HepG2/Adr cells and promoted the cell apoptosis in the presence of DOX. It also increased the retention of P-gp substrates DOX and Rhodamine 123 while did not affect the ATPase activity. [Biochem Biophys Res Commun] Abstract

Repression of Liver Cirrhosis Achieved by Inhibitory Effect of miR-454 on Hepatic Stellate Cells Activation and Proliferation via Wnt10a

TGF-β1 caused the down-regulation of the miR-454 in hepatic stellate cells (HSC)-T6 cells. miR-454 inhibited the activation and proliferation of HSC-T6 cells. Wnt10a had a targeting relationship with miR-454. TGF-β1 promoted HSC-T6 activation and proliferation via down-regulating miR-454 expression, which further up-regulated Wnt10a expression. [J Biochem] Abstract

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The Roles of lncRNA in Hepatic Fibrosis

Hepatic fibrosis is a continuous wound-healing process caused by numerous chronic hepatic diseases, and the activation of hepatic stellate cells is generally considered to be a pivotal step in hepatic fibrosis. [Cell Biosci] Full Article

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Perspectum Diagnostics Announces Collaboration to Advance Development of Therapies for Patients with Serious Liver Disease

Perspectum Diagnostics and the SC Liver Research Consortium announce a collaboration to advance clinical development of investigational therapies. [Perspectum Diagnostics] Press Release

Can-Fite Enters into Collaboration Agreement to Explore Namodenoson’s Anti-NASH Effect with Icahn School of Medicine at Mount Sinai in NYC

Can-Fite BioPharma Ltd. a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, announced a collaborative research agreement with the Icahn School of Medicine at Mount Sinai in New York City. [Can-Fite BioPharma Ltd] Press Release

Take a look at hepatic organoids, their culture and applications. Learn More

South Korean Scientists Protest Treatment of University President Accused of Misusing Funds

Researchers in South Korea have criticized the nation’s science ministry for its handling of an investigation into the president of the Korea Advanced Institute of Science and Technology (KAIST) in Daejon, the country’s top technical university. The science ministry alleges that KAIST leader Shin Sung-Chul made illegal payments to a California lab, but many scientists see a political purge. [Nature News] Editorial

The End of DACA Would Be a Blow to Science

With the end of Deferred Action for Childhood Arrivals (DACA), undocumented scientists will lose what few protections they currently have under immigrant law, lose their access to their scientific research, and once again live in fear, as they are caught in legal limbo. [Scientific American] Editorial

NEW 2019 ASCO Annual Meeting
May 31-June 4, 2019
Chicago, Illinois, United States

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NEW Postdoctoral Position – Liver Disease (University of Illinois)

Research Associate – Cancer Research (University of Cambridge)

Research Associate – Cancer Structural Biology (University of British Columbia)

Postdoctoral Position – Cancer Biology (Fox Chase Cancer Center)

Postdoctoral Scholarships – Medicinal Chemistry, Experimental Biology & Systems Biology (KTH Royal Institute of Technology)

PhD Position – Non-Alcoholic Fatty Liver Disease (Deutsche Diabetes Forschungsgesellschaft e. V)

Postdoctoral Positions – Experimental and Computational Quantitative Single-Cell Biology (Max Planck Institute of Immunobiology and Epigenetics)

Postdoctoral Researcher – Alcohol-Induced Liver Injury (Indiana University)

Postdoctoral Position – Liver Cancer Translational Research (August Pi i Sunyer Biomedical Research Institute)

Postdoctoral Position – Molecular & Integrative Physiology (University of Michigan)

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