Hepatic Cell News 3.33 September 6, 2019 | |
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TOP STORYGREB1 Induced by Wnt Signaling Promotes Development of Hepatoblastoma by Suppressing TGFβ Signaling Forced expression of β-catenin, YAP, and c-Met induced hepatoblastoma (HB)-like mouse liver tumor, with an increase in growth regulation by estrogen in breast cancer 1 (GREB1) expression and HB markers. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Using a newly developed bacterial artificial chromosome-transgenic mouse model, researchers demonstrated that Lgr5 expression in the liver was restricted to a unique subset of hepatocytes most adjacent to the central veins. [Proc Natl Acad Sci USA] Abstract Scientists showed that liver mitochondrial pyruvate carrier (MPC) ablation markedly decreased tumorigenesis and that MPC-deficient tumors transcriptomically downregulated glutathione metabolism. [Cell Rep] Full Article | Graphical Abstract Functional experiments showed that CCL5 deficiency had no effect on the early phase of APAP-induced liver injury but promoted liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration, which were associated with an increased number of hepatic M2 macrophages. [Cell Mol Immunol] Abstract High-fat diet induced an increase in liver total triglycerides and cholesterol, together with the upregulation of genes related to lipogenesis including sterol regulatory element binding-protein 1, steraroyl coenzyme decarboxylase 1, peroxisome proliferator-activated receptor gamma, acetyl-CoA carboxylase 1, and glycerol-3-phosphate acyltransferase, mitochondrial, which were mitigated by indole-3-acetic acid treatment. [Nutrients] Full Article The mechanistic roles of hepatitis B virus (HBV) infection in modulating the expression of miR-122 and apolipoprotein B mRNA-editing enzyme catalytic subunit 2 (APOBEC2), and the development of liver cancer, were investigated. [Int J Oncol] Abstract High levels of nuclear enriched abundant transcript 1 (NEAT1) and ROCK1, and low levels of miR-146a-5p were identified in nonalcoholic fatty liver disease (NAFLD) models. NEAT1 could target miR-146a-5p to promote ROCK1 expression. [Life Sci] Abstract Local Delivery of Arsenic Trioxide Nanoparticles for Hepatocellular Carcinoma Treatment Compared with As2O3, As2O3 nanoparticles (NPs) showed better inhibition, promoted greater LDH release, and induced cell morphology indicative of pyroptosis in vitro. [Signal Transduct Target Ther] Full Article Using stirred-tank culture systems, spheroids of human hepatic cell lines were generated, sustaining a stable hepatic phenotype over four weeks of culture. Spheroids were employed in the establishment of 3D Plasmodium infection platforms that relied on static or dynamic culture conditions. [ACS Infect Dis] Abstract Subscribe to one of our other 19 science newsletters such as Intestinal Cell News & Pancreatic Cell News. | |
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REVIEWSProtective Effects of Polysaccharides on Hepatic Injury: A Review The authors focus on the protective effects of polysaccharides on liver injury, including hepatitis virus infection, nonalcoholic steatohepatitis, alcoholic liver disease and other hepatic injuries, and describe the underlying mechanisms. [Int J Biol Macromol] Abstract Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
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INDUSTRY NEWSInventiva announced the successful completion of patient recruitment for its Phase IIb NATIVE (NASH Trial to Validate IVA337 Efficacy) clinical trial evaluating lanifibranor, the company’s lead product candidate, for the treatment of non-alcoholic steatohepatitis (NASH). [Inventiva] Press Release CytoDyn Files an IND and a Phase II Protocol with the FDA for the Treatment of NASH with Leronlimab CytoDyn Inc. announced the filing of an IND and a Phase II clinical trial protocol with the FDA for the treatment of non-alcoholic steatohepatitis (NASH). [CytoDyn, Inc.] Press Release | |
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POLICY NEWSWorld Health Organization Backs Open-Access Plan S The World Health Organization is joining cOAlition S, a growing group of agencies and charities that fund scientific research and that require their grantees to share their work in open-access journals or repositories. [The Scientist] Editorial New Memo Offers First Glimpse of How Trump’s Science Adviser Would Like to Shape Spending Priorities A new White House directive laying out next year’s spending priorities for federal research agencies describes a US science enterprise imperiled by internal problems and foreign governments. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Stromal Cells in Immunity and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Group Leader – Immunology (University Hospital Düsseldorf) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Research Technologist – Intestinal Stem Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Researcher – Liver Disease (Albert Einstein College of Medicine) Senior Researcher – Inflammatory Diseases (Genentech, Inc.) Postdoctoral Researcher – Microbiome in IBD (GIGA-Medical Genomics Unit) Postdoctoral Fellow – Designer Probiotics (Massachusetts General Hospital) Postdoctoral Researchers – Microbiota in Neonatal Immunity and Imprinting (Institut Pasteur) Principal Researcher – Systems Disease Biology (Boehringer Ingelheim) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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