Hepatic Cell News Volume 4.26 | Jul 17 2020

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    2020-17-07 | HCN 4.26


    Hepatic Cell News by STEMCELL Technologies
    Vol. 4.26 – 17 July, 2020
    TOP STORY

    Mechano-Modulatory Synthetic Niches for Liver Organoid Derivation

    Scientists demonstrated the establishment of biopsy-derived human liver organoids without the use of animal components at any step of the process. Their approach opens up exciting perspectives for the establishment of protocols for liver organoid-based regenerative medicine.
    [Nature Communications]

    Full Article


    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    PUBLICATIONSRanked by the impact factor of the journal

    An FGF15/19-TFEB Regulatory Loop Controls Hepatic Cholesterol and Bile Acid Homeostasis

    Researchers report a role of transcriptional factor EB (TFEB) in regulating hepatic bile acid synthesis. They showed that TFEB induced cholesterol 7α-hydroxylase in human hepatocytes and mouse livers and prevented hepatic cholesterol accumulation and hypercholesterolemia.
    [Nature Communications]

    Full Article

    A Combination of AZD5363 and FH5363 Induces Lethal Autophagy in Transformed Hepatocytes

    Scientists observed that a β-catenin inhibitor (FH535) displayed antiproliferative effect on transformed human hepatocytes. A combination treatment of these cells with FH535 and Akt inhibitor (AZD5363) exerted a stronger effect on cell death.
    [Cell Death & Disease]

    Full Article

    Suppressing DRP1-Mediated Mitochondrial Fission and Mitophagy Increases Mitochondrial Apoptosis of Hepatocellular Carcinoma Cells in the Setting of Hypoxia

    Hepatocellular carcinoma (HCC) cells were subjected to hypoxia and then mitophagy was quantified. The role of dynamin-related protein 1 (DRP1) in hypoxia-induced HCC mitophagy was determined
    [Oncogenesis]

    Full Article

    Quantitative Investigation Into the Influence of Intravenous Fluids on Human Immune and Cancer Cell Lines

    The authors investigated the impact of commonly used intravenous fluids, Dextrose, NaCl and Ringer on HepG2 liver hepatocellular carcinoma and other human cancer lines.
    [Scientific Reports]

    Full Article

    A Small Library of Chalcones Induce Liver Cancer Cell Death through Akt Phosphorylation Inhibition

    Sorafenib and 5FU were analyzed for their bioactivities on six hepatocellular carcinoma cell lines and on dental pulp stem cells which differentiated into hepatocytes, and were used as a model for untransformed control cells.
    [Scientific Reports]

    Full Article

    The Effect of Methylselenocysteine and Sodium Selenite Treatment on MicroRNA Expression in Liver Cancer Cell Lines

    miRNAs critical for liver function were selected and their expression was measured in hepatocellular carcinoma and cholangiocarcinoma cell lines using individual TaqMan microRNA assays following selenite or methylselenocysteine treatments.
    [Pathology & Oncology Research]

    Full Article

    A New Protocol for Long‐Term Culture of a Specific Subpopulation of Liver Cancer Stem Cells Enriched by Cell Surface Markers

    Scientists provided a new in vitro long‐term culture model for a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
    [Febs Open Bio]

    Full Article

    Request a free copy of the Growing Organoids from Stem Cells Wallchart
    REVIEWS

    From Overnutrition to Liver Injury: AMP-Activated Protein Kinase in Nonalcoholic Fatty Liver Diseases

    The authors review the pathogenesis of nonalcoholic fatty liver diseases (NAFLD), and the impact of AMP-activated protein kinase activity state on hepatic steatosis, inflammation, liver injury and fibrosis during the transition of NAFLD to nonalcoholic steatohepatitis and liver failure.
    [Journal of Biological Chemistry]

    Full Article

    INDUSTRY AND POLICY NEWS

    Celsion Corporation Receives Recommendation from Independent Data Monitoring Committee to Consider Stopping the Phase III OPTIMA Study

    Celsion Corporation announced that it has received a recommendation from the independent Data Monitoring Committee to consider stopping the global Phase III OPTIMA Study of ThermoDox® in combination with radiofrequency ablation for the treatment of hepatocellular carcinoma, or primary liver cancer.
    [Celsion Corporation]

    Press Release

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

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    JOB OPPORTUNITIES

    Postdoctoral Position – Liver Carcinogenesis Mechanisms

    UT Health – San Antonio, Texas, United States

    Postdoctoral Position – Gut-Liver and Gut-Brain Axis

    University of California – Davis, California, United States

    Senior Scientist – Obesity & Liver Disease Research

    Novo Nordisk A/S – Copenhagen, Denmark

    Postdoctoral Researcher – Liver Glucose Metabolism

    Lund University Diabetes Centre – Lund, Sweden

    Postdoctoral Positions – Inflammatory Bowel Diseases and Tumor Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

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