| Vol. 4.26 – 17 July, 2020 |
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| Scientists demonstrated the establishment of biopsy-derived human liver organoids without the use of animal components at any step of the process. Their approach opens up exciting perspectives for the establishment of protocols for liver organoid-based regenerative medicine. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report a role of transcriptional factor EB (TFEB) in regulating hepatic bile acid synthesis. They showed that TFEB induced cholesterol 7α-hydroxylase in human hepatocytes and mouse livers and prevented hepatic cholesterol accumulation and hypercholesterolemia. [Nature Communications] |
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| Scientists observed that a β-catenin inhibitor (FH535) displayed antiproliferative effect on transformed human hepatocytes. A combination treatment of these cells with FH535 and Akt inhibitor (AZD5363) exerted a stronger effect on cell death. [Cell Death & Disease] |
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| Hepatocellular carcinoma (HCC) cells were subjected to hypoxia and then mitophagy was quantified. The role of dynamin-related protein 1 (DRP1) in hypoxia-induced HCC mitophagy was determined [Oncogenesis] |
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| The authors investigated the impact of commonly used intravenous fluids, Dextrose, NaCl and Ringer on HepG2 liver hepatocellular carcinoma and other human cancer lines. [Scientific Reports] |
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| Sorafenib and 5FU were analyzed for their bioactivities on six hepatocellular carcinoma cell lines and on dental pulp stem cells which differentiated into hepatocytes, and were used as a model for untransformed control cells. [Scientific Reports] |
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| miRNAs critical for liver function were selected and their expression was measured in hepatocellular carcinoma and cholangiocarcinoma cell lines using individual TaqMan microRNA assays following selenite or methylselenocysteine treatments. [Pathology & Oncology Research] |
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| Scientists provided a new in vitro long‐term culture model for a specific subpopulation of liver cancer stem cells enriched by cell surface markers. [Febs Open Bio] |
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| The authors review the pathogenesis of nonalcoholic fatty liver diseases (NAFLD), and the impact of AMP-activated protein kinase activity state on hepatic steatosis, inflammation, liver injury and fibrosis during the transition of NAFLD to nonalcoholic steatohepatitis and liver failure. [Journal of Biological Chemistry] |
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| Celsion Corporation announced that it has received a recommendation from the independent Data Monitoring Committee to consider stopping the global Phase III OPTIMA Study of ThermoDox® in combination with radiofrequency ablation for the treatment of hepatocellular carcinoma, or primary liver cancer. [Celsion Corporation] |
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| Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing. [Nature News] |
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| August 27 – August 29 Virtual |
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| UT Health – San Antonio, Texas, United States |
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| University of California – Davis, California, United States |
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| Novo Nordisk A/S – Copenhagen, Denmark |
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| Lund University Diabetes Centre – Lund, Sweden |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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