Hepatic Cell News Volume 4.27 | Jul 24 2020

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    2020-24-07 | HCN 4.27


    Hepatic Cell News by STEMCELL Technologies
    Vol. 4.27 – 24 July, 2020
    TOP STORY

    Comparative Analysis of Cell Lineage Differentiation during Hepatogenesis in Humans and Mice at the Single-Cell Transcriptome Level

    Investigators performed single-cell RNA sequencing of whole human and mouse fetal livers throughout development. They identified four cell lineage families of endoderm-derived, erythroid, non-erythroid hematopoietic, and mesoderm-derived non-hematopoietic cells, and defined the developmental pathways of the major cell lineage families.
    [Cell Research]

    Full Article

    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Hepatic Peroxisomal β-Oxidation Suppresses Lipophagy via RPTOR Acetylation and MTOR Activation

    Scientists showed that hepatic acyl-Coenzyme A oxidase 1, palmitoyl deficiency decreased the total cytosolic acetyl-CoA levels, which led to reduced acetylation of RPTOR/RAPTOR, a component of MTORC1, which is a key regulator of macroautophagy/autophagy.
    [Autophagy]

    Abstract

    Anlotinib Suppresses Tumor Progression via Blocking the VEGFR2/PI3K/Akt Cascade in Intrahepatic Cholangiocarcinoma

    Using in vitro experiments, investigatora found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
    [Cell Death & Disease]

    Full Article

    Insulin Signaling and Glucose Metabolism in Different Hepatoma Cell Lines Deviate from Hepatocyte Physiology toward a Convergent Aberrant Phenotype

    The authors investigated insulin signaling, gluconeogenic gene expression, glucose production, and fatty acid synthase abundance in primary hepatocytes and in HepG2, Hepa 1–6, and McARH7777 hepatoma cell lines.
    [Scientific Reports]

    Full Article

    MCD Diet-Induced Steatohepatitis Generates a Diurnal Rhythm of Associated Biomarkers and Worsens Liver Injury in Klf10 Deficient Mice

    Silencing Krüppel like factor 10 (Klf10) sensitized primary hepatocytes to apoptosis along with increased caspase 3 activation in response to TNFα.
    [Scientific Reports]

    Full Article

    Regulation of MYO18B mRNA by a Network of C19MC miRNA-520G, Ifn-γ, Cebpb, p53 and bFGF in Hepatocellular Carcinoma

    Researchers identified a network of positive and negative regulators of MYO18B mRNA expression which reflects the survival of hepatocellular carcinoma patients.
    [Scientific Reports]

    Full Article

    Artesunate Synergizes with Sorafenib to Induce Ferroptosis in Hepatocellular Carcinoma

    Scientists investigated the combined effect of sorafenib and artesunate in inducing ferroptosis of hepatocellular carcinoma and elucidated the involved molecular mechanisms.
    [Acta Pharmacologica Sinica]

    Abstract

    Antimalarial Agent Artesunate Induces G0/G1 Cell Cycle Arrest and Apoptosis via Increasing Intracellular ROS Levels in Normal Liver Cells

    Researchers investigated the possible cytotoxic effects using normal BRL-3A and AML12 liver cells.
    [Human & Experimental Toxicology]

    Abstract

    Learn more about HepatiCult Organoid Growth Medium (Mouse)
    REVIEWS

    NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes

    The authors focus on the clinical and pathophysiological connections between non-alcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes.
    [Diabetology & Metabolic Syndrome]

    Full Article

    INDUSTRY AND POLICY NEWS

    Terns Pharmaceuticals Announces Initiation of Patient Dosing in the LIFT Study, a Phase IIa Clinical Trial of TERN-101 in Development for NASH

    Terns Pharmaceuticals, Inc., has announced that it has dosed the first patient in the LIFT study, a Phase IIa clinical trial of TERN-101, a liver-selective farnesoid X receptor agonist, the company’s lead development candidate for the treatment of non-alcoholic steatohepatitis (NASH).
    [Terns Pharmaceuticals]

    Press Release

    French Science Bill Promises Boost to Public R&D

    The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Editorial

    Foreign Researchers Accused of Hiding Links to Chinese Military

    Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
    [The Scientist]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Pancreatic and Liver Malignancies

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Position – Liver Carcinogenesis Mechanisms

    UT Health – San Antonio, Texas, United States

    Postdoctoral Position – Gut-Liver and Gut-Brain Axis

    University of California – Davis, California, United States

    Senior Scientist – Obesity & Liver Disease Research

    Novo Nordisk A/S – Copenhagen, Denmark

    Postdoctoral Researcher – Liver Glucose Metabolism

    Lund University Diabetes Centre – Lund, Sweden

    > See All Jobs

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