Hepatic Cell News Volume 4.28 | Jul 31 2020

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    2020-31-07 | HCN 4.28


    Hepatic Cell News by STEMCELL Technologies
    Vol. 4.28 – 31 July, 2020
    TOP STORY

    A Large-Scale Binding and Functional Map of Human RNA-Binding Proteins

    Scientists describe the mapping and characterization of RNA elements recognized by a large collection of human RNA-binding proteins in K562 and HepG2 cells.
    [Nature]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    The Hepatocyte Clock and Feeding Control Chronophysiology of Multiple Liver Cell Types

    Researchers showed that deletion of core clock components REV-ERBα and β in adult mouse hepatocytes disrupted diurnal rhythms of a subset of liver genes and altered the diurnal rhythm of de novo lipogenesis.
    [Science]

    Abstract

    Transcriptome Profiling Identifies TIGIT as a Marker of T Cell Exhaustion in Liver Cancer

    Investigators performed for the first time a comprehensive mRNA profiling of CD8 T cells in a murine model of autochthonous liver cancer by comparing the transcriptome of naive, functional effector and exhausted, tumor‐specific CD8 T cells.
    [Hepatology]

    Full Article

    MicroRNA-93-5p Promotes Hepatocellular Carcinoma Progression via a MicroRNA-93-5p/MAP3K2/C-Jun Positive Feedback Circuit

    miR-93-5p expression was assessed in hepatocellular carcinoma (HCC) tissues and cell lines by quantitative real-time PCR and fluorescence in situ hybridization. The correlation of miR-93-5p expression with survival and clinicopathological features of HCC was determined by statistical analysis.
    [Oncogene]

    Abstract

    Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

    By generating an ATF6 inducible patient-specific induced pluripotent stem cell line, researchers demonstrated that enhancing hepatic ER proteostasis preferentially reduced the secretion of amyloidogenic transthyretin.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

    Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
    [Signal Transduction and Targeted Therapy]

    Full Article

    CircularRNA-9119 Protects Hepatocellular Carcinoma Cells from Apoptosis by Intercepting miR-26a/JAK1/STAT3 Signaling

    Investigators showed that circ9119 could modulate apoptosis, and broadly, cell proliferation by competitively binding miR-26a, which targeted JAK1-STAT3, in hepatocellular carcinoma cell lines.
    [Cell Death & Disease]

    Full Article

    Fatty Acid Mimetic PBI-4547 Restores Metabolic Homeostasis via GPR84 in Mice with Non-Alcoholic Fatty Liver Disease

    The authors evaluated the potential of PBI-4547 for the treatment of non-alcoholic fatty liver disease and to validate the role of its main target receptor, G protein-coupled receptor 84 (GPR84).
    [Scientific Reports]

    Full Article

    Overexpression of miR-382 Sensitizes Hepatocellular Carcinoma Cells to γδ T Cells through Inhibiting the Expression of C-Flip

    As miR-382 was observed to be downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, researchers found that overexpression of miR-382 increased the sensitivity of HCC cells to γδ T cells.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

    AMPK Activator C24 Inhibits Hepatic Lipogenesis and Ameliorates Dyslipidemia in HFHC Diet-Induced Animal Models

    Researchers showed that C24 dose-dependently increased the phosphorylation of AMPKα and acetyl-CoA carboxylase, and inhibited lipogenesis in HepG2 cells.
    [Acta Pharmacologica Sinica]

    Abstract

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    REVIEWS

    Emerging Role of FBXO22 in Carcinogenesis

    Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
    [Cell Death Discovery]

    Full Article

    INDUSTRY AND POLICY NEWS

    Terns Pharmaceuticals Announces Completion and Positive Results from Phase I Clinical Trial of TERN-201, a SSAO Inhibitor in Development for NASH

    Terns Pharmaceuticals, Inc., has announced positive results from its completed Phase I single ascending dose and multiple ascending dose study of TERN-201, a semicarbazide-sensitive amine oxidase inhibitor, being developed for the treatment of non-alcoholic steatohepatitis (NASH).
    [Terns Pharmaceuticals]

    Press Release

    China’s Coronavirus Vaccines Are Leaping Ahead – but Face Challenges as Virus Wanes

    Chinese companies are at the forefront of global efforts to create a vaccine for the coronavirus, with more than half a dozen candidates in clinical development. Yet the companies could face difficulty as they try to push vaccines through Phase III trials, a crucial stage of testing that is needed to prove efficacy and secure approval from regulators.
    [Nature News]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Diabetes and Cancer Metabolism

    City of Hope – Duarte, California, United States

    Postdoctoral Fellow – Pancreatic and Liver Malignancies

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Position – Liver Carcinogenesis Mechanisms

    UT Health – San Antonio, Texas, United States

    Postdoctoral Position – Gut-Liver and Gut-Brain Axis

    University of California – Davis, California, United States

    Senior Scientist – Obesity & Liver Disease Research

    Novo Nordisk A/S – Copenhagen, Denmark

    > See All Jobs

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