| Vol. 4.28 – 31 July, 2020 |
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| Scientists describe the mapping and characterization of RNA elements recognized by a large collection of human RNA-binding proteins in K562 and HepG2 cells. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that deletion of core clock components REV-ERBα and β in adult mouse hepatocytes disrupted diurnal rhythms of a subset of liver genes and altered the diurnal rhythm of de novo lipogenesis. [Science] |
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| Investigators performed for the first time a comprehensive mRNA profiling of CD8 T cells in a murine model of autochthonous liver cancer by comparing the transcriptome of naive, functional effector and exhausted, tumor‐specific CD8 T cells. [Hepatology] |
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| miR-93-5p expression was assessed in hepatocellular carcinoma (HCC) tissues and cell lines by quantitative real-time PCR and fluorescence in situ hybridization. The correlation of miR-93-5p expression with survival and clinicopathological features of HCC was determined by statistical analysis. [Oncogene] |
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| By generating an ATF6 inducible patient-specific induced pluripotent stem cell line, researchers demonstrated that enhancing hepatic ER proteostasis preferentially reduced the secretion of amyloidogenic transthyretin. [Stem Cell Reports] |
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| Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells. [Signal Transduction and Targeted Therapy] |
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| Investigators showed that circ9119 could modulate apoptosis, and broadly, cell proliferation by competitively binding miR-26a, which targeted JAK1-STAT3, in hepatocellular carcinoma cell lines. [Cell Death & Disease] |
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| The authors evaluated the potential of PBI-4547 for the treatment of non-alcoholic fatty liver disease and to validate the role of its main target receptor, G protein-coupled receptor 84 (GPR84). [Scientific Reports] |
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| As miR-382 was observed to be downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, researchers found that overexpression of miR-382 increased the sensitivity of HCC cells to γδ T cells. [Molecular Therapy-Oncolytics] |
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| Researchers showed that C24 dose-dependently increased the phosphorylation of AMPKα and acetyl-CoA carboxylase, and inhibited lipogenesis in HepG2 cells. [Acta Pharmacologica Sinica] |
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| Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies. [Cell Death Discovery] |
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| Terns Pharmaceuticals, Inc., has announced positive results from its completed Phase I single ascending dose and multiple ascending dose study of TERN-201, a semicarbazide-sensitive amine oxidase inhibitor, being developed for the treatment of non-alcoholic steatohepatitis (NASH). [Terns Pharmaceuticals] |
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| Chinese companies are at the forefront of global efforts to create a vaccine for the coronavirus, with more than half a dozen candidates in clinical development. Yet the companies could face difficulty as they try to push vaccines through Phase III trials, a crucial stage of testing that is needed to prove efficacy and secure approval from regulators. [Nature News] |
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| City of Hope – Duarte, California, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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| UT Health – San Antonio, Texas, United States |
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| University of California – Davis, California, United States |
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| Novo Nordisk A/S – Copenhagen, Denmark |
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