Hepatic Cell News Volume 4.30 | Aug 14 2020

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    HCN 4.30 | 2020-08-14


    Hepatic Cell News by STEMCELL Technologies
    Vol. 4.30 – 14 August, 2020
    TOP STORY

    Hepatocyte Pyroptosis and Release of Inflammasome Particles Induce Stellate Cell Activation and Liver Fibrosis

    Researchers demonstrated that primary mouse and human hepatocytes can undergo pyroptosis upon NLRP3 inflammasome activation with subsequent release of NLRP3 inflammasome proteins that amplified and perpetuated inflammasome-driven fibrogenesis.
    [Journal of Hepatology]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Yap Is Crucial for CAR‐Driven Hepatocyte Proliferation, but not for Induction of Drug Metabolism Genes in Mice

    Scientists investigated a direct role of Yap in constitutive androstane receptor (CAR)‐driven hepatomegaly and hepatocyte proliferation using hepatocyte‐specific Yap‐KO mice. AAV8‐TBG‐CRE vector was injected to Yap‐floxed mice for achieving hepatocyte‐specific Yap deletion followed by TCPOBOP‐treatment.
    [Hepatology]

    Abstract

    HGF and IL-10 Expressing ALB::GFP Reporter Cells Generated From iPSCs Show Robust Anti-Fibrotic Property in Acute Fibrotic Liver Model

    Induced hepatocyte-like (iHep) cells were generated from induced pluripotent stem cells integrated with the albumin reporter gene. The therapeutic properties of these iHep cells were investigated after transplantation in fibrotic liver tissues of a mouse model.
    [Stem Cell Research & Therapy]

    Full Article

    32A9, a Novel Human Antibody for Designing an Immunotoxin and CAR-T Cells against Glypican-3 in Hepatocellular Carcinoma

    The 32A9 immunotoxin exhibited specific cytotoxicity to GPC3-positive cancer cells, while 32A9 CAR-T cells efficiently eliminated glypican-3-positive hepatocellular carcinoma cells in vitro.
    [Journal of Translational Medicine]

    Full Article

    Reduced Mrp2 Surface Availability as PI3Kγ-Mediated Hepatocytic Dysfunction Reflecting a Hallmark of Cholestasis in Sepsis

    Mrp2 levels at the plasma membrane of PI3Kγ KO hepatocytes remained unaffected upon PI3K/Akt signaling stimulation. The effect explicitly relied on PI3Kγ’s enzymatic ability, as shown by PI3Kγ kinase-dead mice.
    [Scientific Reports]

    Full Article

    Molecular Determinants of SR-B1-Dependent Plasmodium sporozoite Entry into Hepatocytes

    Investigators showed that mouse scavenger receptor class B type 1 (SR-B1) was less functional as compared to human SR-B1 during P. berghei infection. They took advantage of this functional difference to investigate the structural determinants of SR-B1 required for infection.
    [Scientific Reports]

    Full Article

    Neohesperidin Enhances PGC-1α-Mediated Mitochondrial Biogenesis and Alleviates Hepatic Steatosis in High Fat Diet Fed Mice

    Neohesperidin (NHP) elevated hepatic mitochondrial biogenesis and fatty acid oxidation by increasing PGC-1α expression. The activation of AMP-activated protein kinase was involved in NHP induced PGC-1α expression.
    [FASEB Journal]

    Full Article

    FBX8 Promotes Metastatic Dormancy of Colorectal Cancer in Liver

    Scientists revealed a novel mechanism of FBX8 in regulating tumor metastatic dormancy in liver and provided new strategies for the treatment of colorectal cancer metastasis.
    [Cell Death & Disease]

    Full Article

    LncRNA KCNQ1OT1 Regulates the Invasion and Migration of Hepatocellular Carcinoma by Acting on S1PR1 through miR-149

    A xenograft tumour assay was used to validate the role of KCNQ1OT1 in vivo. KCNQ1OT1 and S1PR1 were significantly increased, but miR-149 was decreased in hepatocellular carcinoma cells.
    [Cancer Gene Therapy]

    Abstract

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    REVIEWS

    Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies

    Scientists propose a new vaccine platform that enhances all three arms of the adaptive immune system to improve tumor‐associated antigens‐based cancer vaccination in hepatocellular carcinoma patients.
    [Hepatology]

    Abstract

    Targeted Therapy for Hepatocellular Carcinoma

    Researchers examine recent advances in targeted therapy and discuss the impact this has had on the management of hepatocellular carcinoma (HCC). They also provide an overview of the most important areas of HCC research including novel clinical trials and technical platforms which promise to facilitate substantial progress within the next decade.
    [Signal Transduction and Targeted Therapy]

    Full Article

    The Potent Roles of Salt-Inducible Kinases (SIKs) in Metabolic Homeostasis and Tumorigenesis

    The authors comprehensively summarize the emerging upstream regulators, downstream substrates, mouse models, clinical relevance, and candidate inhibitors for SIKs, and shed light on SIKs as the potential therapeutic targets for cancer therapies.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    Dicerna Announces Positive Clinical Data for Investigational Treatments RG6346 for Chronic Hepatitis B Virus and Nedosiran for Primary Hyperoxaluria

    Dicerna Pharmaceuticals, Inc. has announced positive data from its Phase I proof-of-concept trial of RG6346, an investigational candidate for the treatment of chronic hepatitis B virus infection in development in collaboration with Roche.
    [Dicerna Pharmaceuticals, Inc.]

    Press Release

    Provectus Biopharmaceuticals Expands Sponsored Research Collaboration with University of Calgary (Canada) to Investigate Oral Administration of Rose Bengal Disodium for Cancer Treatment

    Provectus has announced that they have expanded its sponsored research program with the Cumming School of Medicine of the University of Calgary. The Calgary team will investigate oral dosing of cGMP rose bengal disodium in in vivo murine models for the treatment of refractory adult solid tumors that are high-risk phenotypes, including head and neck, breast, pancreatic, liver, and colorectal.
    [Provectus Biopharmaceuticals, Inc. (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Research Postdoctoral Fellow – Non-Alcoholic Fatty Liver Diseases & T2D

    John Hopkins Medical Institute – Baltimore, Maryland, United States

    Staff Scientist – Molecular Diagnostics & Experimental Therapeutics

    City of Hope – Monrovia, California, United States

    Postdoctoral Fellow – Diabetes and Cancer Metabolism

    City of Hope – Duarte, California, United States

    Postdoctoral Fellow – Pancreatic and Liver Malignancies

    Weill Cornell Medicine – New York City, New York, United States

    Postdoctoral Position – Liver Carcinogenesis Mechanisms

    UT Health – San Antonio, Texas, United States

    > See All Jobs

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