Hepatic Cell News Volume 4.32 | Aug 28 2020

May 12, 2022

HCN 4.32 | 2020-08-28

Hepatic Cell News by STEMCELL Technologies

Vol. 4.32 – 28 August, 2020

TOP STORY

METTL6 Is a tRNA m³C
Methyltransferase that Regulates Pluripotency and Tumor Cell Growth

Investigators undertook a combination of in vitro and in vivo screens to test 78 potential methyltransferases for their roles in hepatocellular carcinoma cell proliferation. They identified methyltransferase-like protein 6 (METTL6) as a crucial regulator of tumor cell growth.
[Science Advances]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

C-Jun
Acts Downstream of PI3K/AKT Signaling to Mediate the Effect of Leptin on Methionine Adenosyltransferase 2B in Hepatic Stellate Cells In Vitro and In Vivo

Scientists investigated the effect of leptin on the expression of Mat2b in hepatic stellate cells in vitro and in a leptin‐deficient mouse model. Results demonstrated that leptin significantly increased Mat2b expression.
[Journal of Pathology]

Abstract

Loss
of PTEN Expression Is Associated with PI3K Pathway-Dependent Metabolic Reprogramming in Hepatocellular Carcinoma

Researchers discovered that loss of PTEN allowed the tumor metabolic program, a major advance in understanding the carcinogenesis of hepatocellular carcinoma.
[Cell Communication and Signaling]

Full Article Graphical Abstract

Prognostic
Model of Patients with Liver Cancer Based on Tumor Stem Cell Content and Immune Process

The recurrence of liver hepatocellular carcinoma (LIHC) is closely related to two aspects: degree of immune infiltration and content of tumor stem cells. Scientists used RNA-seq and clinical data of LIHC from The Cancer Genome Atlas, Estimation of Stromal and Immune cells in Malignant Tumours, mRNA stemness index score, and weighted gene correlation network analysis methods to find genes significantly linked to the aforementioned two aspects.
[Aging]

Full Article

Tissue-Targeted R-Spondin Mimetics for Liver Regeneration

Investigators mutated R-spondin (RSPO2 F105R/F109A) to eliminate LGR binding while preserving ZNRF3/RNF43 binding and targeted the mutated RSPO to a liver specific receptor, ASGR1.
[Scientific Reports]

Full Article

A Newly Isolated Strain of Halomonas sp.
(HA1) Exerts Anticancer Potential via Induction of Apoptosis and G₂/M Arrest in Hepatocellular Carcinoma (HepG2) Cell Line

Researchers suggested that the apoptotic and anti-proliferative effects of HA1 extracted on HepG2 cells could provide it as a candidate for future pharmaceutical industries.
[Scientific Reports]

Full Article

LncUBE2R2-AS1
Acts as a MicroRNA Sponge of miR-302b to Promote HCC Progression via Activation EGFR-PI3K-AKT Signaling Pathway

Functional experiments showed that knockdown UBE2R2-AS1 inhibited hepatocellular carcinoma (HCC) growth and metastasis through in vitro and in vivo experiments.
[Cell Cycle]

Abstract

Co-Culture
with Mouse Embryonic Fibroblasts Improves Maintenance of Metabolic Function of Human Small Hepatocyte Progenitor Cells

The authors report that small hepatocyte progenitor cells derived from adult primary human hepatocytes (PHHs) and cultured on mouse embryonic fibroblasts not only displayed differentiated morphology and exhibited gene expression profiles similar to adult PHHs, but importantly, they retained their phenotype over several passages.
[Current Research in Toxicology]

Full Article Graphical Abstract

The Effect of Matrix Stiffness on Human Hepatocyte Migration and Function—An In Vitro
Research

To investigate the effect of extracellular matrix stiffness on hepatocyte migration and function, scientists designed an easy fabricated polyvinyl alcohol hydrogel in which stiffness could be controlled by changing the concentration of glutaraldehyde.
[Polymers]

Abstract Full Article

Co-Cultured
Bone Marrow Mesenchymal Stem Cells Repair Thioacetamide-Induced Hepatocyte Damage

The authors investigated the restorative effects of mouse bone marrow mesenchymal stem cells (mBMSCs) on thioacetamide‐induced damage in hepatocytes. An in vitro trans‐well co‐culture system of HepG2 cells were co‐cultured with mBMSCs.
[Cell Biology International]

Abstract

In Vitro:
Cytotoxicity, Apoptosis and Ameliorative Potential of Lawsonia inermis extract in Human Lung, Colon and Liver Cancer Cell Lines

Bioactive components of Lawsonia inermis extract were analyzed by the LCMS/MS method and validated. Lawsone (3.5%) is primarily responsible for cytotoxic and anti-cancerous activities. These properties were studied on human lung carcinoma, colorectal cancer and hepatocellular carcinoma cancer cell lines.
[Cancer Investigation]

Abstract

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REVIEWS

Key Players of Hepatic Fibrosis

Scientists explore the causes and mechanisms of hepatic fibrosis and focus on the roles of key molecules involved in liver fibrogenesis, some of which are potential targets for therapeutics to hamper liver fibrogenesis.
[Journal of Interferon and Cytokine Research]

Abstract

Role
of MicroRNA-7 in Liver Diseases: A Comprehensive Review of the Mechanisms and Therapeutic Applications

The authors focus on the mechanisms by which miR-7 controls cell growth, proliferation, invasion, metastasis, metabolism, and inflammation. They also summarize the specific roles of miR-7 in liver diseases.
[Journal of Investigative Medicine]

Abstract

INDUSTRY AND POLICY NEWS

Viking Therapeutics Presents New Data from Phase II Study of VK2809 in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Elevated LDL-Cholesterol at The Digital International Liver Congress™ 2020

Viking Therapeutics, Inc. presented new results from the company’s 12-week Phase II study of VK2809 in patients with NAFLD and elevated low-density lipoprotein (LDL)-cholesterol at the Digital International Liver Congress™ 2020.
[Viking Therapeutics, Inc. (PR Newswire)]

Press Release

FEATURED EVENT

METTL6 Is a tRNA m³C
Methyltransferase that Regulates Pluripotency and Tumor Cell Growth

C-Jun
Acts Downstream of PI3K/AKT Signaling to Mediate the Effect of Leptin on Methionine Adenosyltransferase 2B in Hepatic Stellate Cells In Vitro and In Vivo

Loss
of PTEN Expression Is Associated with PI3K Pathway-Dependent Metabolic Reprogramming in Hepatocellular Carcinoma

Prognostic
Model of Patients with Liver Cancer Based on Tumor Stem Cell Content and Immune Process

Tissue-Targeted R-Spondin Mimetics for Liver Regeneration

A Newly Isolated Strain of Halomonas sp.
(HA1) Exerts Anticancer Potential via Induction of Apoptosis and G₂/M Arrest in Hepatocellular Carcinoma (HepG2) Cell Line

LncUBE2R2-AS1
Acts as a MicroRNA Sponge of miR-302b to Promote HCC Progression via Activation EGFR-PI3K-AKT Signaling Pathway

Co-Culture
with Mouse Embryonic Fibroblasts Improves Maintenance of Metabolic Function of Human Small Hepatocyte Progenitor Cells

The Effect of Matrix Stiffness on Human Hepatocyte Migration and Function—An In Vitro
Research

Co-Cultured
Bone Marrow Mesenchymal Stem Cells Repair Thioacetamide-Induced Hepatocyte Damage

In Vitro:
Cytotoxicity, Apoptosis and Ameliorative Potential of Lawsonia inermis extract in Human Lung, Colon and Liver Cancer Cell Lines

Key Players of Hepatic Fibrosis

Role
of MicroRNA-7 in Liver Diseases: A Comprehensive Review of the Mechanisms and Therapeutic Applications

Viking Therapeutics Presents New Data from Phase II Study of VK2809 in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Elevated LDL-Cholesterol at The Digital International Liver Congress™ 2020

Cancer Research & Oncology 2020

> See All Events

Research
Assistant – Liver Immunology Group

Research
PostDoctoral – NAFLD and Mitochondrial Dysfunction

Post-Doctoral Fellow – HBV & SARS-CoV-2

Staff
Scientist – Molecular Diagnostics & Experimental Therapeutics

Postdoctoral Fellow – Pancreatic and Liver Malignancies

> See All Jobs