 | | Vol. 4.36 – 25 September, 2020 |
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| Scientists determined that phosphate and tensin homology deleted on chromosome ten (PTEN) deficiency promoted protein synthesis and proteasome subunit expression and proteolytic activity, creating a dependency on the proteasome for cancer cell growth and survival.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report that T and NK cells transduced with a chimeric antigen receptor that recognize the surface marker, CD147, also known as Basigin, could effectively kill various malignant hepatocellular carcinoma (HCC) cell lines in vitro, and HCC tumors in xenograft and patient-derived xenograft mouse models.
[Nature Communications] |
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| ISG12a was found to be expressed at low levels in gastrointestinal cancer, represented by hepatocellular cancer and gastric cancer, and identified as a tumor suppressor that affects clinical prognosis.
[Cellular & Molecular Immunology] |
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| High expression of DHCR24 in human hepatocellular carcinoma (HCC) specimens was correlated with poor clinical outcome. Interfering DHCR24 altered growth and migration of HCC cells.
[British Journal of Cancer] |
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| Scientists report a novel mechanism that contributed to acetaminophen-induced hepatotoxicity through the induction of ferroptosis, a distinctive form of programmed cell death.
[Cell Death & Disease] |
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| Researchers demonstrated that cytoplasmic polyadenylation element-binding protein 3 (CPEB3) played an important role in hepatocellular carcinoma progression and targeting CPEB3-mediated mRNA translation may be a favorable therapeutic approach.
[Cell Death & Disease] |
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| Investigators performed immunoprecipitation-mass spectrometry analysis of hepatocellular carcinoma (HCC) tissues. A vital oncoprotein, Y-box binding protein 1 (YB-1), was shown to interact with β2-adrenergic receptor (β2-AR) in HCC cells.
[Oncogenesis] |
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| Researchers examined whether a nanoemulsified polyunsaturated fatty acid, also known as omega-5, from pomegranate seed oil had beneficial effects on C57BL/6N mice fed a high-fat diet, specifically on hepatic steatosis.
[Scientific Reports] |
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| Investigators found hepatic lipocalin 2 (LCN2) expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with alcoholic hepatitis.
[Scientific Reports] |
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| Scientists describe optimization of current methods and present new protocols for using human papillomavirus capsids to deliver non-viral DNA, thereby providing an alternative to DNA transfection. Using keratinocyte generated extracellular matrices could enhance infection efficiency in keratinocytes, hepatocytes and neuronal cells.
[Scientific Reports] |
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| The authors summarize systematically and comprehensively the myriad of works that appeared in the last decade and lighted the discussion about the best opportunities for using extracellular vesicles in liver disease therapeutics.
[Pharmacology & Therapeutics] |
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| GENFIT have announced the first patient first visit for ELATIVE, the global, pivotal, Phase III study evaluating elafibranor in Primary Biliary Cholangitis (PBC), a severe cholestatic liver disease that impacts and gradually destroys the bile ducts.
[GENFIT] |
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| Agios Pharmaceuticals, Inc. announced the results of the final overall survival analysis from its global Phase III ClarIDHy trial of TIBSOVO® in previously treated cholangiocarcinoma patients with an isocitrate dehydrogenase 1 mutation.
[Agios Pharmaceuticals, Inc.] |
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| November 18, 2020
Virtual |
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| | University of Toronto – Toronto, Ontario, Canada |
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| | University of Miami – Miami, Flordia, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | Vitalant Research Institute – San Francisco, California, United States |
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