 | | Vol. 4.37 – 02 October, 2020 |
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| The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
[Hepatology] |
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| Scientists knocked down the NSUN2 gene in HepG2 cells by CRISPR/Cas9 technology and performed high-throughput RNA-BisSeq. An important tumor-related lncRNA H19 was identified to be targeted by NSUN2.
[Oncogene] |
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| Scientists demostrated that depleting alpha fetoprotein (AFP) significantly suppressed diethylnitrosamine-induced liver tumor progression in an AFP gene-deficient mouse model.
[Cell Death & Disease] |
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| Using bioinformatics analyses, investigators found hepatocarcinogenesis was particularly associated with dysregulated expression of small nucleolar RNA host gene 1 (SNHG1) and activation of the cell cycle pathway.
[Cell Death & Disease] |
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| IL-1α was sufficient to activate cultured fibroblasts and primary hepatic stellate cells in vitro, and IL-1α was elevated in the sera and liver of cachectic, suggesting a mechanism by which chronic IL-1R signaling could be leading to cachexia-associated fibrosis.
[Scientific Reports] |
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| Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy] |
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| Using the human hepatic cell line HepG2 as a model, scientists showed that endoplasmic reticulum associated degradation (ERAD), an ER protein quality control process, was critically required for mitochondrial function in mammalian cells.
[Journal of Biological Chemistry] |
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| The authors highlight how insights into hepatocyte regeneration and biology in vivo can inform in vitro studies to propagate primary hepatocytes with signals in liver regeneration and to generate hepatocytes de novo from pluripotent stem cells.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Investigators provide succinct insights into the molecular mechanisms responsible for lipotoxicity in non-alcoholic fatty liver disease (NAFLD), including ER and oxidative stress, autophagy, lipoapotosis and inflammation. They highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis.
[Cell Death & Disease] |
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| Aligos Therapeutics, Inc. announced that the company has received approval for a clinical trial application for a first-in-human Phase Ia/b proof-of-concept clinical trial. Aligos may now commence study ALG-000184-201 to evaluate ALG-000184, a small molecule class II capsid assembly modulator that targets hepatitis B virus capsid assembly as well as the establishment of covalently closed circular DNA.
[Aligos Therapeutics (GlobeNewswire, Inc.)] |
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| January 1 – January 12, 2021
Lake Buena Vista, Florida, United States |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | University of Toronto – Toronto, Ontario, Canada |
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| | University of Miami – Miami, Florida, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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