| Vol. 4.41 – 6 November, 2020 |
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| Human hepatocellular carcinoma (HCC) cell lines and HCC mouse models were used to assess the therapeutic efficacy and targeted molecular pathways of cabozantinib, either alone or in combination with the pan-mTOR inhibitor MLN0128 or the checkpoint inhibitor anti-PD-L1 antibody. [Gut] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Conditioned media from HepG2 cells overexpressing I148M mutant variant of the patatin‐like phospholipase domain‐containing 3 (PNPLA3) increased procollagen mRNA expression in LX2 cells; this was abrogated by hepatocyte STAT3 inhibition. [Hepatology] |
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| The authors compared the fate of 14C-labeled few-layer graphene with different lateral sizes in mice after one intravenous injection for up to one year and demonstrated that few-layer graphene mainly accumulated in the liver, and larger graphene can be degraded into 14CO2 by Kupffer cells. [ACS Nano] |
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| Using a combination of genetic and chemical assays, scientists showed that the translocon component exported protein 2 (EXP2) was critical for invasion of hepatocytes. [Nature Communications] |
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| Murine hepatocyte expression of both factors was constitutive and not interferon inducible, while differences in liver expression and the ability to restrict hepatitis C virus were observed between the murine orthologs and their human counterparts. [Science Advances] |
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| Researchers assessed the effect of p66Shc on acetaminophen (APAP)-induced liver injury and to evaluate if circular RNA functions as a competitive endogenous RNA to mediate p66Shc in APAP-induced liver injury. [Cell Death & Disease] |
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| The authors’ objective was to trace carbon flux through pathways of oxidation and glucose metabolism in bovine hepatocytes exposed to increasing concentrations of choline chloride and D,L-methionine. [Scientific Reports] |
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| Scientists demonstrated the immune response mediated by an adeno-associated virus (AAV) vector in a mouse model. Mice were infected intravenously with 4×10ˆ12 cp/kg of AAV8 and the ensuing immune response was analyzed using intravital microscopy, over a period of weeks. [Molecular Therapy-Methods & Clinical Development] |
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| Researchers evaluated the effect of 100% human plasma on the uptake clearance using transfected HEK293 cells and primary human hepatocytes, and assessed in vitro–in vivo extrapolation. [Drug Metabolism and Disposition] |
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| The authors identified the embryonic liver developmental trajectory from gut endoderm to hepatoblasts and characterized the transcriptome of the hepatic lineage. [Communications Biology] |
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| Investigators review recent advances regarding the regulation and function of miRNAs in liver diseases with a major focus on miRNAs that are specifically expressed or enriched in hepatocytes, neutrophils, hepatic stellate cells, immune cells and in circulation. [Gut] |
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| Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases. [Cellular & Molecular Immunology] |
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| Roche announced that the European Commission has approved Tecentriq® in combination with Avastin® for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have not received prior systemic therapy. [Roche] |
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| April 9 – April 14, 2021 Washington, DC, United States |
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| Pfizer – Cambridge, Massachusetts, United States |
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| Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| Zhejiang University-University of Edinburgh Institute – Haining, China |
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| Medical University of Vienna – Vienna, Austria |
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| University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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