Hepatic Cell News Volume 4.42 | Nov 6 2020

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    2020-06-11 | HCN 4.41


    Hepatic Cell News by STEMCELL Technologies
    Vol. 4.41 – 6 November, 2020
    TOP STORY

    Cabozantinib-Based
    Combination Therapy for the Treatment of Hepatocellular Carcinoma

    Human hepatocellular carcinoma (HCC) cell lines and HCC mouse models were used to assess the therapeutic efficacy and targeted molecular pathways of cabozantinib, either alone or in combination with the pan-mTOR inhibitor MLN0128 or the checkpoint inhibitor anti-PD-L1 antibody.
    [Gut]

    Abstract


    Learn more about HepatiCult Organoid Growth Medium (Mouse)
    PUBLICATIONSRanked by the impact factor of the journal

    Identification
    of a Metabolic, Transcriptomic and Molecular Signature of PNPLA3‐Mediated Acceleration of Steatohepatitis

    Conditioned media from HepG2 cells overexpressing I148M mutant variant of the patatin‐like phospholipase domain‐containing 3 (PNPLA3) increased procollagen mRNA expression in LX2 cells; this was abrogated by hepatocyte STAT3 inhibition.
    [Hepatology]

    Abstract

    Kupffer Cells Degrade 14C-Labeled Few-Layer Graphene to 14CO2
    in Liver through Erythrophagocytosis

    The authors compared the fate of 14C-labeled few-layer graphene with different lateral sizes in mice after one intravenous injection for up to one year and demonstrated that few-layer graphene mainly accumulated in the liver, and larger graphene can be degraded into 14CO2 by Kupffer cells.
    [ACS Nano]

    Abstract

    Plasmodium Translocon Component EXP2 Facilitates Hepatocyte Invasion

    Using a combination of genetic and chemical assays, scientists showed that the translocon component exported protein 2 (EXP2) was critical for invasion of hepatocytes.
    [Nature Communications]

    Full Article

    Liver-Expressed
    Cd302 and Cr1l Limit Hepatitis C Virus Cross-Species Transmission to Mice

    Murine hepatocyte expression of both factors was constitutive and not interferon inducible, while differences in liver expression and the ability to restrict hepatitis C virus were observed between the murine orthologs and their human counterparts.
    [Science Advances]

    Full Article

    circ-CBFB
    Upregulates p66Shc to Perturb Mitochondrial Dynamics in APAP-Induced Liver Injury

    Researchers assessed the effect of p66Shc on acetaminophen (APAP)-induced liver injury and to evaluate if circular RNA functions as a competitive endogenous RNA to mediate p66Shc in APAP-induced liver injury.
    [Cell Death & Disease]

    Full Article

    Palmitate
    and Pyruvate Carbon Flux in Response to Choline and Methionine in Bovine Neonatal Hepatocytes

    The authors’ objective was to trace carbon flux through pathways of oxidation and glucose metabolism in bovine hepatocytes exposed to increasing concentrations of choline chloride and D,L-methionine.
    [Scientific Reports]

    Full Article

    Modulation
    of the Liver Immune Microenvironment by the Adeno-Associated Virus Serotype 8 Gene Therapy Vector

    Scientists demonstrated the immune response mediated by an adeno-associated virus (AAV) vector in a mouse model. Mice were infected intravenously with 4×10ˆ12 cp/kg of AAV8 and the ensuing immune response was analyzed using intravital microscopy, over a period of weeks.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract

    Effect
    of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes

    Researchers evaluated the effect of 100% human plasma on the uptake clearance using transfected HEK293 cells and primary human hepatocytes, and assessed in vitroin vivo extrapolation.
    [Drug Metabolism and Disposition]

    Abstract

    Embryonic
    Liver Developmental Trajectory Revealed by Single-Cell RNA Sequencing in the Foxa2eGFP Mouse

    The authors identified the embryonic liver developmental trajectory from gut endoderm to hepatoblasts and characterized the transcriptome of the hepatic lineage.
    [Communications Biology]

    Full Article

    Pathogen infection studies lacked an optimal culture system. Then she used organoids.
    REVIEWS

    MicroRNAs
    as Regulators, Biomarkers and Therapeutic Targets in Liver Diseases

    Investigators review recent advances regarding the regulation and function of miRNAs in liver diseases with a major focus on miRNAs that are specifically expressed or enriched in hepatocytes, neutrophils, hepatic stellate cells, immune cells and in circulation.
    [Gut]

    Abstract

    Neutrophils in Liver Diseases: Pathogenesis and Therapeutic Targets

    Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases.
    [Cellular & Molecular Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    European
    Commission Approves Roche’s Tecentriq in Combination with Avastin for the Treatment of People with the Most Common Form of Liver Cancer

    Roche announced that the European Commission has approved Tecentriq® in combination with Avastin® for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have not received prior systemic therapy.
    [Roche]

    Press Release

    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021

    April 9 – April 14, 2021
    Washington, DC, United States


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    JOB OPPORTUNITIES

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    Pfizer – Cambridge, Massachusetts, United States

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    Deep Genomics, Inc. – Toronto, Ontario, Canada

    Postdoctoral Positions – Stem Cells, Immunology, Biochemistry/Molecular Biology, Pathogenic Microbiology

    Zhejiang University-University of Edinburgh Institute – Haining, China

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    Medical University of Vienna – Vienna, Austria

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    University of Texas Southwestern Medical Center – Dallas, Texas, United States

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