 | | Vol. 4.43 – 20 November, 2020 |
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| Researchers showed that compared to expression in adjacent non‐cancerous tissues, RHOF was frequently upregulated in hepatocellular carcinoma tumor samples and elevated under conditions of glucose deprivation.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators synthesized and reported an adiponectin-based agonist JT003, which potently improved insulin resistance in high fat diet induced nonalcoholic steatohepatitis mice and suppresses hepatic stellate cells activation in CCl4 induced liver fibrosis.
[Nature Communications] |
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| S100A9 expression in tumor tissues was associated with poor survival of hepatocellular carcinoma patients. It could enhance the stem cell‐like properties of HepG2 and MHCC‐97H cells by activating nuclear factor‐kappa B signaling pathway through advanced glycosylation end product‐specific receptor in a Ca2+‐dependent manner.
[International Journal of Cancer] |
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| The authors found that translationally controlled tumor protein (TCTP) protein was overexpressed in hepatocellular carcinoma patients but TCTP mRNA expression levels were reversed.
[Cell Death & Disease] |
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| Researchers assessed the hepatocellular carcinoma tumor expression of the extracellular matrix protein proteoglycan 4 and its potential pharmacologic activity either alone, or in combination with sorafenib and regorafenib.
[Cell Death & Disease] |
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| Lower levels of P450 family 2 subfamily C member 8 (CYP2C8) were confirmed in liver cancer cells. CYP2C8 overexpression efficiently attenuated liver cancer cell proliferation and promoted apoptosis.
[Cancer Biology & Therapy] |
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| PAR-γ agonist was found to inhibit primary HSCs and NIH/3T3 fibroblast activation and reverted their phenotypical morphology induced by TGF-β1 in vitro. In addition to this, PPAR-γ agonist decreased expression of TGF-β1 and phosphorylation of Smad2/3 while increased expression of Smad7.
[Journal of Physiology and Biochemistry] |
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| Scientists discuss recent data on a large number of cytokines that play important roles in regulating liver injury, inflammation, fibrosis, and regeneration, with a focus on interferons and T helper (Th) 1, Th2, Th9, Th17, interleukin (IL)-1 family, IL-6 family, and IL-20 family cytokines.
[Cellular & Molecular Immunology] |
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| The spectrum of liver injury in COVID‐19 may range from direct infection by SARS‐CoV‐2, indirect involvement by systemic inflammation, hypoxic changes, iatrogenic causes such as drugs and ventilation to exacerbation of underlying liver disease.
[Liver International] |
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| VBI Vaccines, Inc. announced positive interim clinical results from the ongoing Phase Ib/IIa study of VBI-2601, a novel recombinant, protein-based immunotherapeutic candidate for the treatment of chronic hepatitis B virus infection, in development in collaboration with Brii Biosciences.
[VBI Vaccines, Inc.] |
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| PharmaTher, Inc. has filed a provisional patent application with the US Patent and Trademark Office outlining the potential novel use of psilocybin to treat cancer, which was discovered by panaceAI™, their proprietary psychedelic drug repurposing artificial intelligence platform.
[PharmaTher, Inc. (GlobeNewswire, Inc.)] |
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| May 16 – May 21, 2021
Lucca, Italy |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Stanford University – Stanford, California, United States |
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| | Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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| | Medical University of Vienna – Vienna, Austria |
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