Hepatic Cell News Volume 5.02 | Jan 22 2021

May 12, 2022

2020-01-22 | HCN 5.02

Hepatic Cell News by STEMCELL Technologies

Vol. 5.02 – 22 January, 2021

TOP STORY

Zonal Human Hepatocytes Are Differentially Permissive to Plasmodium
falciparum Malaria Parasites

To understand specific host conditions that affect infectivity, the authors studied Plasmodium falciparum parasite liver stage development in relation to the metabolic heterogeneity of fresh human hepatocytes.
[EMBO Journal]

Full Article

Survey Report: Where Is Pluripotent Stem Cell Research Now?

PUBLICATIONSRanked by the impact factor of the journal

BNIP3-Dependent
Mitophagy Promotes Cytosolic Localization of LC3B and Metabolic Homeostasis in the Liver

Investigators showed that BNIP3 is required for glucagon-induced mitophagy in the liver through interaction with processed LC3B; an interaction that is also necessary to localize LC3B out of the nucleus to cytosolic mitophagosomes in response to nutrient deprivation.
[Autophagy]

Abstract

Circular
RNA circPSD3 Alleviates Hepatic Fibrogenesis by Regulating the miR-92b-3p/Smad7 Axis

In vitro loss-of-function and gain-of-function analyses suggested that circRNA derived from the Pleckstrin and Sec7 domain-containing 3 (circPSD3) inhibited the activation and proliferation of hepatic stellate cells.
[Molecular Therapy-Nucleic Acids]

Abstract Full Article
Graphical Abstract

Inhibition
of Histone Methyltransferase G9a Attenuates Liver Cancer Initiation by Sensitizing DNA-Damaged Hepatocytes to p53-Induced Apoptosis

Using liver-specific G9a-deficient mice, scientists revealed that loss of G9a significantly attenuated liver tumor initiation caused by diethylnitrosamine.
[Cell Death & Disease]

Full Article

Modeling
Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation

The authors developed a human induced pluripotent stem cell-based model of isogenic bile salt export pump-deficient hepatocytes in a Transwell culture system. Induced hepatocytes exhibited defects in the apical export of bile acids but maintained a low intracellular bile acid concentration by inducing basolateral export.
[Stem Cell Reports]

Full Article Graphical Abstract

Inhibiting
CBX4 Efficiently Protects Hepatocellular Carcinoma Cells against Sorafenib Resistance

Hepatocellular carcinom cell lines and a xenograft mouse model with resistance to sorafenib were employed to analyze the effects of miR424 on cancer stem cell characteristics.
[British Journal of Cancer]

Abstract

Targeting
Transdifferentiated Hepatic Stellate Cells and Monitoring the Hepatic Fibrogenic Process by Means of IGF2R-Specific Peptides Designed In Silico

The structural information of the insulin-like growth factor 2 receptor (IGF2R), an overexpressed protein on activated hepatic stellate cells, were used for an in silico screening of novel IGF2R-specific peptide ligands.
[Journal of Materials Chemistry B]

Abstract

Single-Cell
Analysis Reveals the Intra-Tumor Heterogeneity and Identifies MLXIPL as a Biomarker in the Cellular Trajectory of Hepatocellular Carcinoma

Researchers profiled the gene expression of single cells from human hepatocellular carcinoma (HCC) tumor and para-tumor tissues using the Smart-seq 2 sequencing method. Based on differentially expressed genes, they identified heterogeneous subclones in HCC tissues, including five HCC and two hepatocyte subclones.
[Cell Death Discovery]

Full Article

LECT2
as a Hepatokine Links Liver Steatosis to Inflammation via Activating Tissue Macrophages in NASH

Hepatic expression of leukocyte cell-derived chemotaxin 2 (LECT2) was upregulated in association with the inflammatory signature in human liver tissues. The elevation of LECT2 shifted liver residual macrophage to the M1-like phenotype, and contributed to the development of liver inflammation.
[Scientific Reports]

Full Article

Pathogen infection studies lacked an optimal culture system. Then she used organoids.

REVIEWS

Triglycerides
in Nonalcoholic Fatty Liver Disease: Guilty until Proven Innocent

Whether and how triglycerides promote hepatocyte injury remains unclear. Consequently, it is difficult to predict whether drugs designed to reduce hepatic triglycerides will prevent the most important complications of non-alcoholic fatty liver disease.
[Trends in Pharmacological Sciences]

Abstract

In Vitro
Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment

Scientists consider the benefits, limitations, and adaptations of specific in vitro approaches to assess DNA damage in the liver, whilst identifying critical advancements required to support a multitude of biochemical endpoints.
[Small]

Full Article

INDUSTRY AND POLICY NEWS

EMBO Installation Grants Support Eight Early-Career Scientists to Establish Independent Laboratories

EMBO has announced the award of Installation Grants to eight scientists in the early stages of setting up their independent laboratories in Lithuania, Poland, Portugal and Turkey.
[EMBO]

Press Release

FEATURED EVENT

Zonal Human Hepatocytes Are Differentially Permissive to Plasmodium
falciparum Malaria Parasites

BNIP3-Dependent
Mitophagy Promotes Cytosolic Localization of LC3B and Metabolic Homeostasis in the Liver

Circular
RNA circPSD3 Alleviates Hepatic Fibrogenesis by Regulating the miR-92b-3p/Smad7 Axis

Inhibition
of Histone Methyltransferase G9a Attenuates Liver Cancer Initiation by Sensitizing DNA-Damaged Hepatocytes to p53-Induced Apoptosis

Modeling
Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation

Inhibiting
CBX4 Efficiently Protects Hepatocellular Carcinoma Cells against Sorafenib Resistance

Targeting
Transdifferentiated Hepatic Stellate Cells and Monitoring the Hepatic Fibrogenic Process by Means of IGF2R-Specific Peptides Designed In Silico

Single-Cell
Analysis Reveals the Intra-Tumor Heterogeneity and Identifies MLXIPL as a Biomarker in the Cellular Trajectory of Hepatocellular Carcinoma

LECT2
as a Hepatokine Links Liver Steatosis to Inflammation via Activating Tissue Macrophages in NASH

Triglycerides
in Nonalcoholic Fatty Liver Disease: Guilty until Proven Innocent

In Vitro
Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment

EMBO Installation Grants Support Eight Early-Career Scientists to Establish Independent Laboratories

Integrating Metabolism and Immunity

> See All Events

Postdoctoral Fellow – Tumor Biology and Therapeutic Applications

Scientific
Communities & Communications Specialist

Image
Analysis Specialist – Cancer and Chronic Diseases

Associate
Professor – Cancer Biology

Senior
Investigator – Replication Stress and Chromatin Alterations

> See All Jobs