Hepatic Cell News Volume 5.03 | Jan 29 2021

    By
    Justin.choi
    -
    0
    102







    2020-01-29 | HCN 5.04


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.03 – 29 January, 2021
    TOP STORY

    In Vivo Cytidine Base Editing of Hepatocytes without Detectable Off-Target Mutations in RNA and DNA

    Investigators report unbiased analyses of transcriptome-wide and genome-wide off-target modifications effected by cytidine base editors in the liver of mice with phenylketonuria.
    [Nature Biomedical Engineering]

    Abstract

    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    PUBLICATIONSRanked by the impact factor of the journal

    Hyperpolyploidization of Hepatocyte Initiates Preneoplastic Lesion Formation in the Liver

    Hyperpolyploidization of hepatocytes around the centrilobular region was demonstrated to be closely linked with the development of hepatocellular carcinoma cells after diethylnitrosamine treatment.
    [Nature Communications]

    Full Article

    Correction of a Urea Cycle Defect after Ex Vivo Gene Editing of Human Hepatocytes

    Hepatocytes isolated from an ornithine transcarbamylase deficiency patient were genetically corrected ex vivo, through deletion of a mutant intronic splicing site achieving editing efficiencies >60% and restoration of urea cycle in vitro.
    [Molecular Therapy]

    AbstractFull ArticleGraphical Abstract

    TROAP Switches DYRK1 Activity to Drive Hepatocellular Carcinoma Progression

    Mechanistic investigation revealed that trophinin-associated protein directly bound to dual specificity tyrosine phosphorylation regulated kinase 1A/B (DYRK1A/B), resulting in the cytoplasmic retention of proteins DYRK1A/B and promoting cell cycle process via activation of Akt/GSK-3β signaling.
    [Cell Death & Disease]

    Full Article

    Zeb1 Serves An Oncogenic Role In The Tumorigenesis Of HCC By Promoting Cell Proliferation, Migration, And Inhibiting Apoptosis Via Wnt/β-catenin Signaling Pathway

    Scientists demonstrated that the expression level of ZEB1 was significantly elevated both in liver tissues of hepatocellular carcinoma (HCC) patients and cell lines. Moreover, ZEB1 could promote the proliferation, migration, and invasion of HCC cells.
    [Acta Pharmacologica Sinica]

    AbstractGraphical Abstract

    Real-Time Lipid Patterns to Classify Viable and Necrotic Liver Tumors

    The authors explored whether rapid evaporative ionization mass spectrometry lipid patterns ccould identify human liver tumors and improve the rapid characterization of their underlying metabolic features.
    [Laboratory Investigation]

    Abstract

    A Subset of Liver Resident Natural Killer Cells Is Expanded in Hepatitis C-Infected Patients with Better Liver Function

    LMCs were less responsive to toll-like receptor stimulation than blood mononuclear cells, with fewer pro-inflammatory gene-expression pathways up-regulated after in vitro exposure to lipopolysaccharide and a TLR-7/8 agonist.
    [Scientific Reports]

    Full Article

    High-Throughput Toxicogenomic Screening of Chemicals in the Environment Using Metabolically Competent Hepatic Cell Cultures

    Researchers evaluated differentiated HepaRGTM cells, a human liver-derived cell model understood to effectively model physiologically relevant hepatic signaling.
    [npj Systems Biology and Applications]

    Full Article
    Learn more about HepatiCult Organoid Growth Medium (Mouse)
    REVIEWS

    Locoregional Therapies in the Era of Molecular and Immune Treatments for Hepatocellular Carcinoma

    Investigators analyze data from randomized and uncontrolled studies reported with ablative and locoregional techniques and examine the expected effects of combinations with systemic treatments.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    Recent Updates on Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma

    The authors summarize current chimeric antigen receptor T cell (CAR-T) therapy targets in the treatment of hepatocellular carcinoma (HCC), discuss current obstacles and possible solutions in the process, and describe potential strategies to improve the efficacy of CAR-T cells for patients with HCC.
    [Cancer Gene Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    Initial Data from Ongoing Phase I Trial of VIR-3434 for Chronic Hepatitis B Virus Infection Demonstrates Significant and Rapid Reduction in Hepatitis B Surface Antigen

    Vir Biotechnology, Inc. announced initial topline data from its ongoing trial of VIR-3434 in patients with chronic hepatitis B virus infection. Data from the first blinded cohort of eight patients, two of whom received placebo and six of whom received a single dose of 6 mg of VIR-3434, showed that six of eight patients achieved a mean reduction of 1.3 log10 IU/mL in serum hepatitis B virus surface antigen by day eight, the day when nadir was achieved in most patients.
    [Vir Biotechnology, Inc.]

    Press Release
    FEATURED EVENT

    EMBO Workshop: Autophagy in Brain Health and Disease

    March 24 – 27, 2021
    Sant Feliu de Guixols, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Development of Fatty Liver Disease and Fibrosis

    University of Connecticut – Storrs, Connecticut, United States

    Assistant Professor – Pediatric Hepatologist

    BC Children’s Hospital – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Tumor Biology and Therapeutic Applications

    Harvard Medical School – Boston, Massachusetts, United States

    Image Analysis Specialist – Cancer and Chronic Diseases

    Novo Nordisk – Copenhagen, Denmark

    Associate Professor – Cancer Biology

    University of Cincinnati – Cincinnati, Ohio, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hepatic Cell News Twitter