| Vol. 5.04 – 5 February, 2021 |
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| The authors investigated the transmembrane tight junction protein Claudin6 (CLDN6) as a therapeutic target related to lineage plasticity for hepatocellular carcinoma. [Science Translational Medicine] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells, a subpopulation in glioblastoma critical for malignancy. [Molecular Cell] |
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| Public hepatocellular carcinoma (HCC) datasets were assessed for concomitant presence of CTNNB1 mutations and either mutations in NFE2L2 or KEAP1, or Nrf2 activation by gene signature. [Hepatology] |
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| Lnc-UCID expression was quantified in hepatocellular carcinoma (HCC) tissues and HCC cell lines by qRT-PCR. HCC cell lines with lnc-UCID knockdown were established by lentivirus transduction. [Oncotargets and Therapy] |
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| Proliferating primary human hepatocytes (PHH) generated from multiple PHH donors were expanded more than 200 folds within four passages, partially maintained their metabolic or transporter capacities, and were able to regain their mature hepatic property after 3D culture. [Drug Metabolism and Disposition] |
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| Researchers observed that Aspergillus niger strongly bound to both HepG2 and HT‐29 cell‐lines and this interaction was effectively blocked with L‐fucose and mucin in a dose and time‐dependent manner with an IC50 of 1.25 and 5μg/mL for HepG2 and HT‐29 cells respectively at 48 hours. [Cell Biochemistry and Function] |
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| While hepatocyte-specific c-jun deletion led to increased fibrosis, the opposite outcome was observed when c-jun was deleted in both hepatocytes and Kupffer cells. [Life Science Alliance] |
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| Increasing molecular evidence supports the clonal nature of combined hepatocellular-cholangiocarcinoma (CCA) and molecular profile parallels its biphenotypic histological appearance, with genetic alterations that are classically observed in hepatocellular carcinoma and/or intrahepatic CCA. [Journal of Hepatology] |
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| EB1 could promote the proliferation, migration, and invasion of hepatocellular carcinoma cells. On the downstream regulation mechanism, ZEB1 could activate the Wnt/β-catenin signaling pathway by upregulating the protein expression levels of β-catenin, c-Myc, and cyclin D1. [Acta Pharmacologica Sinica] |
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| VBI Vaccines, Inc. announced that the FDA has accepted its filing of the Biologics License Application for the company’s 3-antigen prophylactic hepatitis B vaccine candidate for the prevention of infection caused by all known subtypes of the hepatitis B virus in adults. [VBI Vaccines, Inc.] |
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| Karolinska Institutet – Stockholm, Sweden |
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| University of Connecticut – Storrs, Connecticut, United States |
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| BC Children’s Hospital – Vancouver, British Columbia, Canada |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| Novo Nordisk – Copenhagen, Denmark |
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